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Antigen Contact Residues in Catalytic Antibodies and Hapten Binders

Hapten Binders (top view)
Oligomer Binders (top view)
Protein Binders (top view)

Bottom, left to right:
Sequence Variability in HuCAL I (only CDR3 randomized), in HuCAL II (all CDRs randomized) and in natural human Antibodies