Things to come:
How To Build and Evaluate a Model
Template Evaluation
Critical Points
Model evaluation
Examples: Predictions and Results
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The Human Combinatorial Antibody Library (HuCAL)
HuCal VK Frameworks
HuCal VK 1
HuCal VK 2
HuCal VK 3
HuCal VK 4
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HuCal VL Frameworks
HuCal VL 1
HuCal VL 2
HuCal VL 3
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HuCal VH Frameworks
HuCal VH 1a
HuCal VH 1b
HuCal VH 2
HuCal VH 3
HuCal VH 4
HuCal VH 5
HuCal VH 6
Randomization: HuCal I (CDR3 only)
Randomization: HuCal II (all CDRs)
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Biophysical Properties of Antibody Construct
Thermodynamic Stability and Folding Efficiency of the HuCAL Human Germline Consensus Frameworks
Camelid VHH
The Influence of Domain Interactions on Stability
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Troubleshooting Antibody Single Chain Fragments (scFV)
CDR Grafting and Humanization by Resurfacing
Identifying Individual Problem Spots
Highly Conserved Residues
Torsion Angles, Conserved Glycin and Prolin Residues
Framework 1 Conformation, Core Side Chain Hydrogen Bonding Pattern and Effects of Primer-Induced Mutations
Hydrophobic Core Packing
Buried Charge Cluster
Effects of Surface Hydrophobic Residues on Folding Efficiency and Stability
TheDimer Interface
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Optimized Randomization Strategies for Synthetic Antibody Libraries
How Antibodies bind Antigens: Analysis of Contact Residues and Indirect Contributions to Binding
Reproducing the Natural Repertoire
Optimizing for Protein Binders
Optimizing for Peptide Binders
Optimizing for Hapten Binders
Optimizing for Catalysis - COSSACS Talk
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