Things to come:
- How To Build and Evaluate a Model
- Template Evaluation
- Critical Points
- Model evaluation
- Examples: Predictions and Results
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- The Human Combinatorial Antibody Library (HuCAL)
- HuCal VK Frameworks
- HuCal VK 1
- HuCal VK 2
- HuCal VK 3
- HuCal VK 4
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- HuCal VL Frameworks
- HuCal VL 1
- HuCal VL 2
- HuCal VL 3
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- HuCal VH Frameworks
- HuCal VH 1a
- HuCal VH 1b
- HuCal VH 2
- HuCal VH 3
- HuCal VH 4
- HuCal VH 5
- HuCal VH 6
- Randomization: HuCal I (CDR3 only)
- Randomization: HuCal II (all CDRs)
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- Biophysical Properties of Antibody Construct
- Thermodynamic Stability and Folding Efficiency of the HuCAL Human Germline Consensus Frameworks
- Camelid VHH
- The Influence of Domain Interactions on Stability
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- Troubleshooting Antibody Single Chain Fragments (scFV)
- CDR Grafting and Humanization by Resurfacing
- Identifying Individual Problem Spots
- Highly Conserved Residues
- Torsion Angles, Conserved Glycin and Prolin Residues
- Framework 1 Conformation, Core Side Chain Hydrogen Bonding Pattern and Effects of Primer-Induced Mutations
- Hydrophobic Core Packing
- Buried Charge Cluster
- Effects of Surface Hydrophobic Residues on Folding Efficiency and Stability
- TheDimer Interface
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- Optimized Randomization Strategies for Synthetic Antibody Libraries
- How Antibodies bind Antigens: Analysis of Contact Residues and Indirect Contributions to Binding
- Reproducing the Natural Repertoire
- Optimizing for Protein Binders
- Optimizing for Peptide Binders
- Optimizing for Hapten Binders
- Optimizing for Catalysis - COSSACS Talk
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