Introduction Numbering Sequences Structures Modelling Macros Publications Links
Homology Modelling CDR Grafting Examples HuCAL Biophysical Properties Randomization Catalytic Antibodies

 Things to come:

How To Build and Evaluate a Model
Template Evaluation
Critical Points
Model evaluation
Examples: Predictions and Results
The Human Combinatorial Antibody Library (HuCAL)
HuCal VK Frameworks
HuCal VK 1
HuCal VK 2
HuCal VK 3
HuCal VK 4
HuCal VL Frameworks
HuCal VL 1
HuCal VL 2
HuCal VL 3
HuCal VH Frameworks
HuCal VH 1a
HuCal VH 1b
HuCal VH 2
HuCal VH 3
HuCal VH 4
HuCal VH 5
HuCal VH 6
Randomization: HuCal I (CDR3 only)
Randomization: HuCal II (all CDRs)
 Biophysical Properties of Antibody Construct
Thermodynamic Stability and Folding Efficiency of the HuCAL Human Germline Consensus Frameworks
Camelid VHH
The Influence of Domain Interactions on Stability
Troubleshooting Antibody Single Chain Fragments (scFV)
CDR Grafting and Humanization by Resurfacing
Identifying Individual Problem Spots
Highly Conserved Residues
Torsion Angles, Conserved Glycin and Prolin Residues
Framework 1 Conformation, Core Side Chain Hydrogen Bonding Pattern and Effects of Primer-Induced Mutations
Hydrophobic Core Packing
Buried Charge Cluster
Effects of Surface Hydrophobic Residues on Folding Efficiency and Stability
TheDimer Interface
Optimized Randomization Strategies for Synthetic Antibody Libraries
How Antibodies bind Antigens: Analysis of Contact Residues and Indirect Contributions to Binding
Reproducing the Natural Repertoire
Optimizing for Protein Binders
Optimizing for Peptide Binders
Optimizing for Hapten Binders
Optimizing for Catalysis - COSSACS Talk
AAAAA Homepage Zürich University Dept. of Biochemistry Plückthun Group Annemarie Honegger

Last Modified by A.Honegger Wednesday, November 7, 2001