IMGT, the international ImMunoGeneTics database

• human VH germline sequences
• human Vk germline sequences, murine, rabbit
• human Vl germline sequences, murine, ovine
• human Va germline sequences
• human Vb germline sequences, murine
• human Vg germline sequences, murine
• human Vd germline sequences, murine

Lefranc, M.-P. et al., Nucl. Acids Res. 27(1999) 209-212;

Ruiz, M. et al., Nucl. Acids Res., 28 (2000) 219-221 ;

Lefranc, M.-P., Nucl. Acids Res., 29 (2001) 207-209 .

IMGT numbering scheme

Correspondence to other numbering schemes

Kabat et al., Sequences of Proteins of Immunological Interest,

NIH Publication n. 91-3242 (1991)
Chothia and Lesk, J. Mol. Biol. 196:901-917 (1987);

Williams, Frippiat et al., J. Mol. Biol., 264:220-232 (1996);

ABG, Antibody Group (Juan Carlos Almagro, Ph.D.)

• murine VH germline sequences
• murine Vk germline sequences
• directory of 3D structures
• interface to Kabat database
• references

VBase, the database of human antibody genes

Ian Tomlinson, imt@mrc-lmb.cam.ac.uk, fax +44 1223 402140
MRC Centre for Protein Engineering, Hills Road,

Cambridge CB2 2QH, U.K.

• human VH germlines
• human Vk germlines
• human Vl germlines

Kabat Database

Compiled by Elvin A. Kabat (1914-2000), maintained by George Johnson & Tai Te Wu

• SeqhuntII
• Wu-Kabat-Variability
• Align A Sequence
• Subgrouping
• Family Assignment

The Canonical Sequence Approximation

Dr. Boris Steipe
Genzentrum der Ludwig-Maximilians-Universität

• VH combined
• VH mouse
• VH human
• Vk combined
• Vl mouse
• Vl Human

The Protein Data Bank

International repository for the processing and distribution of 3-D macromolecular structure data primarily determined experimentally.

H.M.Berman, J.Westbrook, Z.Feng, G.Gilliland, T.N.Bhat, H.Weissig, I.N.Shindyalov, P.E.Bourne: The Protein Data Bank. Nucleic Acids Research, 28 pp. 235-242 (2000)

Antibodies - Structure and Sequence

Dr. Andrew C.R. Martin, Lecturer in Bioinformatics, School of Animal & Microbial Sciences, University of Reading

• AbCheck - Antibody Sequence Test
• Canonicals - Chothia Canonical Assignment
• Human Subgroup Assignment

Morphosys

Home of the HuCAL Human Combinatorial Antibody Library

Fully Synthetic Human Combinatorial Antibody Libraries (HuCAL) Based on Modular Consensus Frameworks and CDRs Randomized with Trinucleotides (A. Knappik, L. Ge, A. Honegger, P. Pack, M. Fischer, G. Wellnhofer, A. Hoess, J. Wölle, A. Plückthun, B. Virnekäs J. Mol. Biol. 296 (2000) 57-86.)

WAM - Web Antibody Modelling

automated modelling using the AbM Antibody modelling algorithm

Martin ACR, Cheetham JC and Rees AR, Meth.Enz. 203 (1991) p121

Martin ACR, Cheetham JC and Rees AR, Proc. Natl. Acad. Sci. USA 86 (1989) p9268

The Antibody Ressource Page

How to Find an Antibody, Online Companies that Sell Antibodies, Custom Antibody Suppliers, Contract Antibody Suppliers, |Educational Resources. Immunology and Biotechnology Sites, Databases/Software, Antibody Gallery Antibody News, Journals, Books, FAQ

The Antibody Web (by Stefan Dübel)

Humanization By Design (by José Saldanha)

Mike's Immunoglobulin Structure/Function Home Page

NACCESS - Solvent accessible area calculations

using the Lee & Richards (1971, J. Mol. Biol., 55, 379-400) method, program by S. Hubbard and J. Thornton

GCG Wisconsin package

The Wisconsin Package contains over 130 programs. Based on published algorithms from the fields of mathematical and computational biology, the Package includes programs that can be categorized within these functional groups:

• Comparison
• Database Searching and Retrieval
• DNA/RNA Secondary Structure
• Editing and Publication
• Evolution
• Fragment Assembly
• Gene Finding and Pattern Recognition
• Importing and Exporting
• Mapping
• Primer Selection
• Protein Analysis
• Translation