Catalytic Antibodies and Antibody Library Design:

Analysis of the Binding Mode: Size of the binding pocket

Nitrophenol Binding Pocket

Contact Residues: Alignment VK, Alignment VH

Structural Alignment

Contact Residues

Position dependent Sequence Variability

Sequence variability of the natural Antibody Repertoire and of Synthetic Libraries:

Kabat Plot, Mapped onto the 3D Structure

Contribution to Binding Vs. Variability

What does this mean for the Probability of finding Catalysts?

Last Modified by A.Honegger Thursday, November 8, 2001