IgG2a Structure (Mab 231) - 1igt

Secondary structure cartoon

a-Helix: red

b-Sheet: yellow

Turn: dark blue

Random coil: green

Ribbon colored according to chain

light chains: pink, magenta

heavy chains: cyan, blue

SS-bonds yellow

Ribbon colored according to domain

VL: magenta

CL: pink

VH: blue

CH: cyan

Hinge: blue-green

CH2: green

CH3: yellow-green

sugar residues: white,cpk

Antigen contact residues (Average over all antigen complexes)

red: strong contact, >80% reduction in accessibility upon comples formation

red-orange: 60-80% reduction

orange: 40-60% reduction

yellow-orange: 20-40% reduction

yellow: <20% reduction

white: no contact

VL/VH contact residues

CL/CH contact residues

VL/CL and VH/CH contact residues

no direct CH2/CH2 protein-protein contacts

CH3/CH3 contact residues

CH2/CH3 contact residues