Introduction Numbering Sequences Structures Modelling Macros Publications Links
Homology Modelling CDR Grafting Examples HuCAL Biophysical Properties Randomization Randomization

load 4D5/ab48 Hybrid (framework) model
all sequences identical
hybrid-typical sequences
H106 Tyr->Cys
H59 Asn->Ser
H77 Lys->Arg 

load anti-GCN4 (loop donor) model
all sequences identical
GCN4-typical sequences 

load kappa graft model
all sequences identical
CDR sequences taken from anti-GCN4
framework sequences taken from 4D5/ab48 Hybrid

 load lambda graft model
all sequences identical
CDR sequences taken from anti-gcn4
framework sequences taken from hybrid
differences between lambda and kappa graft

Display all
Display backbone only
Display as spacefilling
Display as sticks
Color by atom type
Color by residue type
Color by chain
Highlight charges
positive Phi angles
cis/trans Pro residues
H-Bonds

Display VL only, VH only
V/C interf. VH+VL
Core residues VH+VL
Dimer interf. Haptens
VH, VL
Dimer interf. Oligom
. VH, VL
Dimer interf. Protein
s VH, VL
Antigen interf. Haptens
Antigen interf. Oligom.
Antigen interf. Proteins
CDRs VL, CDRs VH

anti-GCN4 scFV

AAAAA Homepage Zürich University Dept. of Biochemistry Plückthun Group Annemarie Honegger

Last Modified by A.Honegger Wednesday, November 7, 2001