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Catalase

Kinds of Catalase

Different cells build different types of catalase. Many are available for study in the PDB. The catalase that protects our red blood cells, shown on the left from PDB entry 1qqw, is composed of four identical subunits and uses a heme/iron group to perform the reaction. Many bacteria scavenge hydrogen peroxide with a larger catalase, shown in the center from PDB entry 1iph, that uses a similar arrangement of iron and heme. Other bacteria protect themselves with an entirely different catalase that uses manganese ions instead of heme, as shown at the right from PDB entry 1jku. For more information on catalases from a genomic perspective, take a look at the Protein of the Month at the European Bioinformatics Institute.

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