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Estrogen Receptor
Exploring the Structure
You can look at the DNA-binding part of the estrogen receptor in PDB entry 1hcq. The receptor binds to DNA using two "zinc fingers." These are small domains built around zinc ions. Four cysteine amino acids (shown in yellow here) surround each zinc ion (shown in green), forming a sturdy core that gives the domain a rigid structure. The receptor places an alpha helix in the major groove of DNA--in this picture, we are looking straight down the helix. Several amino acids on one side of this helix reach out and grip the edges of the base pairs, making sure that the DNA is of the appropriate sequence.This illustration was created with RasMol. You can create similar illustrations by clicking on the accession codes in this article and then picking one of the options under View Structure.
A list of all estrogen receptor structures in the PDB as of September, 2003, is available here. For more information on the estrogen receptor, click here.
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Last changed by: A.Honegger,