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p53 Tumor Suppressor
Embracing DNA
p53 tumor suppressor binds to DNA using all four of its arms. The typical binding site for the whole molecule is composed of three parts: a specific binding site for two p53 domains, a variable stretch of 0 to 13 base pairs, and a second specific binding site for the other two p53 domains. In the picture shown here (constructed from PDB entries 1tup, 1olg and 1ycq), two p53 domains are bound near the top of the DNA strand and two are bound at an identical site near the bottom. The tetramerization domain is behind the helix, tying all four chains together, and the four transactivation domains extend along the DNA helix, ready to activate neighboring proteins involved in reading the DNA. The flexible chains that connect all four arms together allow p53 to bind to many different variants of this binding site, allowing it to regulate transcription at many places in the genome.Next: Exploring the Structure
Previous: Guardian of the Cell
Last changed by: A.Honegger,