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Thrombin
| PDB ID | Authors | First Page | Journal Name | Title | Volume No | Publication Year |
| 1A0H | P.D.Martin, M.G.Malkowski, J.Box, C.T.Esmon, B.F.Edwards | 1681 | Structure | New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK. | 5 | 1997 |
| 1A2C | J.L.R.Steiner, M.Murakami, A.Tulinsky | 597 | J Am Chem Soc | Structure of thrombin inhibited by aeruginosin 298-A from a blue-green alga. | 120 | 1998 |
| 1A3B | A.Zdanov, S.Wu, J.DiMaio, Y.Konishi, Y.Li, X.Wu, B.F.Edwards, P.D.Martin, M.Cygler | 252 | Proteins | Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6. | 17 | 1993 |
| 1A3E | A.Zdanov, S.Wu, J.DiMaio, Y.Konishi, Y.Li, X.Wu, B.F.Edwards, P.D.Martin, M.Cygler | 252 | Proteins | Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6. | 17 | 1993 |
| 1A4W | J.H.Matthews, R.Krishnan, M.J.Costanzo, B.E.Maryanoff, A.Tulinsky | 2830 | Biophys J | Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site. | 71 | 1996 |
| 1A61 | R.St Charles, J.H.Matthews, E.L.Zhang, A.Tulinsky | 1376 | J Med Chem | Bound structures of novel P3-P1 ' beta-strand mimetic inhibitors of thrombin. | 42 | 1999 |
| 1ABI | X.Qiu, K.P.Padmanabhan, V.E.Carperos, A.Tulinsky, T.Kline, J.M.Maraganore, .2.Fenton 2d | 11689 | Biochemistry | Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. | 31 | 1992 |
| 1ABJ | X.Qiu, K.P.Padmanabhan, V.E.Carperos, A.Tulinsky, T.Kline, J.M.Maraganore, .2.Fenton 2d | 11689 | Biochemistry | Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. | 31 | 1992 |
| 1AD8 | J.A.Malikayil, J.P.Burkhart, H.A.Schreuder, R.J.Broersma Jr., C.Tardif, .3.Kutcher 3rd, S.Mehdi, G.L.Schatzman, B.Neises, N.P.Peet | 1034 | Biochemistry | Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety. | 36 | 1997 |
| 1AHT | Z.Chen, Y.Li, A.M.Mulichak, S.D.Lewis, J.A.Shafer | 198 | Arch Biochem Biophys | Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution. | 322 | 1995 |
| 1AI8 | W.Bode, D.Turk, A.Karshikov | 426 | Protein Sci | The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. | 1 | 1992 |
| 1AIX | W.Bode, D.Turk, A.Karshikov | 426 | Protein Sci | The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. | 1 | 1992 |
| 1ANT | R.W.Carrell, P.E.Stein, G.Fermi, M.R.Wardell | 257 | Structure | Biological implications of a 3 A structure of dimeric antithrombin [see comments] | 2 | 1994 |
| 1ATH | H.A.Schreuder, B.de Boer, R.Dijkema, J.Mulders, H.J.Theunissen, P.D.Grootenhuis, W.G.Hol | 48 | Nat Struct Biol | The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions. | 1 | 1994 |
| 1ATT | L.Mourey, J.P.Samama, M.Delarue, M.Petitou, J.Choay, D.Moras | 223 | J Mol Biol | Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution. | 232 | 1993 |
| 1AVG | P.Fuentes-Prior, C.Noeske-Jungblut, P.Donner, W.D.Schleuning, R.Huber, W.Bode | 11845 | Proc Natl Acad Sci U S A | Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug. | 94 | 1997 |
| 1AWF | M.P.Weir, S.S.Bethell, A.Cleasby, C.J.Campbell, R.J.Dennis, C.J.Dix, H.Finch, H.Jhoti, C.J.Mooney, S.Patel, C.M.Tang, M.Ward, A.J.Wonacott, C.W.Wharton | 6645 | Biochemistry | Novel natural product 5,5-trans-lactone inhibitors of human alpha- thrombin: mechanism of action and structural studies. | 37 | 1998 |
| 1AWH | M.P.Weir, S.S.Bethell, A.Cleasby, C.J.Campbell, R.J.Dennis, C.J.Dix, H.Finch, H.Jhoti, C.J.Mooney, S.Patel, C.M.Tang, M.Ward, A.J.Wonacott, C.W.Wharton | 6645 | Biochemistry | Novel natural product 5,5-trans-lactone inhibitors of human alpha- thrombin: mechanism of action and structural studies. | 37 | 1998 |
| 1AY6 | B.E.Maryanoff, X.Qiu, K.P.Padmanabhan, A.Tulinsky, H.R.Almond Jr., P.Andrade-Gordon, M.N.Greco, J.A.Kauffman, K.C.Nicolaou, A.Liu, et al. | 8048 | Proc Natl Acad Sci U S A | Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. | 90 | 1993 |
| 1AZX | L.Jin, J.P.Abrahams, R.Skinner, M.Petitou, R.N.Pike, R.W.Carrell | 14683 | Proc Natl Acad Sci U S A | The anticoagulant activation of antithrombin by heparin. | 94 | 1997 |
| 1B7X | E.R.Guinto, S.Caccia, T.Rose, K.Futterer, G.Waksman, E.Di Cera | 1852 | Proc Natl Acad Sci U S A | Unexpected crucial role of residue 225 in serine proteases. | 96 | 1999 |
| 1BA8 | R.Krishnan, E.Zhang, K.Hakansson, R.K.Arni, A.Tulinsky, M.S.Lim-Wilby, O.E.Levy, J.E.Semple, T.K.Brunck | 12094 | Biochemistry | Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. | 37 | 1998 |
| 1BB0 | R.Krishnan, E.Zhang, K.Hakansson, R.K.Arni, A.Tulinsky, M.S.Lim-Wilby, O.E.Levy, J.E.Semple, T.K.Brunck | 12094 | Biochemistry | Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. | 37 | 1998 |
| 1BBR | P.D.Martin, W.Robertson, D.Turk, R.Huber, W.Bode, B.F.Edwards | 7911 | J Biol Chem | The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution. | 267 | 1992 |
| 1BCU | E.Conti, C.Rivetti, A.Wonacott, P.Brick | 229 | FEBS Lett | X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human alpha-thrombin. | 425 | 1998 |
| 1BHX | J.Wagner, J.Kallen, C.Ehrhardt, J.P.Evenou, D.Wagner | 3664 | J Med Chem | Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors. | 41 | 1998 |
| 1BMM | M.F.Malley, L.Tabernero, C.Y.Chang, S.L.Ohringer, D.G.Roberts, J.Das, J.S.Sack | 221 | Protein Sci | Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090. | 5 | 1996 |
| 1BMN | M.F.Malley, L.Tabernero, C.Y.Chang, S.L.Ohringer, D.G.Roberts, J.Das, J.S.Sack | 221 | Protein Sci | Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090. | 5 | 1996 |
| 1BR8 | R.Skinner, W.S.Chang, L.Jin, X.Pei, J.A.Huntington, J.P.Abrahams, R.W.Carrell, D.A.Lomas | 9 | J Mol Biol | Implications for function and therapy of a 2.9 A structure of binary- complexed antithrombin. | 283 | 1998 |
| 1BTH | A.van de Locht, W.Bode, R.Huber, B.F.Le Bonniec, S.R.Stone, C.T.Esmon, M.T.Stubbs | 2977 | EMBO J | The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin. | 16 | 1997 |
| 1C1U | B.A.Katz, J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross, C.Luong, W.R.Moore, R.M.Stroud | 608 | Nature | Design of Potent Selective Zinc-Mediated Serine Protease Inhibitors | 391 | 1998 |
| 1C1V | B.A.Katz, J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross, C.Luong, W.R.Moore, R.M.Stroud | 608 | Nature | Design of Potent Selective Zinc-Mediated Serine Protease Inhibitors | 391 | 1998 |
| 1C1W | B.A.Katz, J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross, C.Luong, W.R.Moore, R.M.Stroud | 608 | Nature | Design of Potent Selective Zinc-Mediated Serine Protease Inhibitors | 391 | 1998 |
| 1C4U | R.Krishnan, I.Mochalkin, R.K.Arni, A.Tulinsky | 294 | Acta Crystallogr., Sect.D | Structure of Thrombin Complexed with Selective Non-Electrophilic Inhibitors Having Cyclohexyl Moieties at P1 | 56 | 2000 |
| 1C4V | R.Krishnan, I.Mochalkin, R.K.Arni, A.Tulinsky | 294 | Acta Crystallogr., Sect.D | Structure of Thrombin Complexed with Selective Non-Electrophilic Inhibitors Having Cyclohexyl Moieties at P1 | 56 | 2000 |
| 1C4Y | R.Krishnan, I.Mochalkin, R.K.Arni, A.Tulinsky | 294 | Acta Crystallogr., Sect.D | Structure of Thrombin Complexed with Selective Non-Electrophilic Inhibitors Having Cyclohexyl Moieties at P1 | 56 | 2000 |
| 1C5L | B.A.Katz, R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang, H.Chan, L.Wong | 299 | Chem.Biol. | Structural Basis for Selectivity of a Small Molecule, S1-Binding, Submicromolar Inhibitor of Urokinase-Type Plasminogen Activator | 7 | 2000 |
| 1C5N | B.A.Katz, R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang, H.Chan, L.Wong | 299 | Chem.Biol. | Structural Basis for Selectivity of a Small Molecule, S1-Binding, Submicromolar Inhibitor of Urokinase-Type Plasminogen Activator | 7 | 2000 |
| 1C5O | B.A.Katz, R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang, H.Chan, L.Wong | 299 | Chem.Biol. | Structural Basis for Selectivity of a Small Molecule, S1-Binding, Submicromolar Inhibitor of Urokinase-Type Plasminogen Activator | 7 | 2000 |
| 1CA8 | R.Krishnan, E.Zhang, K.Hakansson, R.K.Arni, A.Tulinsky, M.S.Lim-Wilby, O.E.Levy, J.E.Semple, T.K.Brunck | 12094 | Biochemistry | Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. | 37 | 1998 |
| 1CXM | S.M.T.Serrano, A.Wisner, C.Bon, R.C.Maroun | n/a | To be Published | A Comparative Study of Two Thrombin-Like Serine Proteinases from Bothrops Jararaca'S Venom | n/a | 1999 |
| 1D3T | N.Y.Chirgadze, D.J.Sall, S.L.Briggs, D.K.Clawson, M.Zhang, G.F.Smith, R.W.Schevitz | 29 | Protein Sci. | The Crystal Structures of Human [Alpha]-Thrombin Complexed with Active Site-Directed Diamino Benzo[B]Thiophene Derivatives: A Binding Mode for a Structurally Novel Class of Inhibitors | 9 | 2000 |
| 1D4P | N.Y.Chirgadze, D.J.Sall, V.J.Klimkowski, D.K.Clawson, S.L.Briggs, R.Hermann, G.F.Smith, D.S.Gifford-Moore, J.P.Wery | 1412 | Protein Sci. | The Crystal Structure of Human A-Thrombin Complexed with Ly178550, Non-Peptidyl, Active-Site Directed Inhibitor | 6 | 1997 |
| 1D6W | R.Krishnan, I.Mochalkin, R.Arni, A.Tulinsky | 294 | Acta Crystallogr., Sect.D | Structure of Thrombin Complexed with Selective Non-Electrophilic Inhibitors Having Cyclohexyl Moieties at P1 | 56 | 2000 |
| 1D9I | R.Krishnan, I.Mochalkin, R.Arni, A.Tulinsky | 294 | Acta Crystallogr., Sect.D | Structure of Thrombin Complexed with Selective Non-Electophilic Inhibitors Having Cyclohexyl Moieties at P1 | 56 | 2000 |
| 1DE7 | C.Sadasivan, V.C.Yee | 36942 | J.Biol.Chem. | Interaction of the Factor Xiii Activation Peptide with Alpha-Thrombin. Crystal Structure of its Enzyme-Substrate Analog Complex | 275 | 2000 |
| 1DIT | R.Krishnan, A.Tulinsky, G.P.Vlasuk, D.Pearson, P.Vallar, P.Bergum, T.K.Brunck, W.C.Ripka | 422 | Protein Sci | Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic. | 5 | 1996 |
| 1DM4 | R.Krishnan, E.J.Sadler, A.Tulinsky | 406 | Acta Crystallogr., Sect.D | Structure of Ser195Ala Mutant of Human-Thrombin Complexed with Fibrinopeptide A(7-16): Evidence for Residual Catalytic Activity | 56 | 2000 |
| 1DOJ | R.Recacha, M.J.Costanzo, B.E.Maryanoff, M.Carson, L.Delucas, D.Chattopadhyay | 1395 | Acta Crystallogr., Sect.D | Structure of Human-Thrombin Complexed with Rwj-51438 at 1.7 A: Unusual Perturbation of the 60A-60I Insertion Loop | 56 | 2000 |
| 1DWB | D.W.Banner, P.Hadvary | 20085 | J Biol Chem | Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. | 266 | 1991 |
| 1DWC | D.W.Banner, P.Hadvary | 20085 | J Biol Chem | Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. | 266 | 1991 |
| 1DWD | D.W.Banner, P.Hadvary | 20085 | J Biol Chem | Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. | 266 | 1991 |
| 1DWE | D.W.Banner, P.Hadvary | 20085 | J Biol Chem | Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. | 266 | 1991 |
| 1DX5 | P.Fuentes-Prior, Y.Iwanaga, R.Huber, R.Pagila, G.Rumennik, M.Seto, J.Morser, D.R.Light, W.Bode | 518 | Nature | Structural Basis for the Anticoagulant Activity of the Thrombin-Thrombomodulin Complex | 404 | 2000 |
| 1DZG | J.A.Huntington, A.J.Mccoy, K.J.Belzar, X.Y.Pei, P.G.W.Gettins, R.W.Carrell | 15377 | J.Biol.Chem. | The Conformational Activation of Antithrombin-A 2.85 Angstrom Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge Region and Heparin Binding Regions | 275 | 2000 |
| 1DZH | J.A.Huntington, A.J.Mccoy, K.J.Belzar, X.Y.Pei, P.G.W.Gettins, R.W.Carrell | 15377 | J.Biol.Chem. | The Conformational Activation of Antithrombin-A 2.85 Angstrom Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge Region and Heparin Binding Regions | 275 | 2000 |
| 1E03 | L.Jin, J.-P.Abrahams, R.Skinner, M.Petitou, R.N.Pike, R.W.Carrell | 601 | Proc.Nat.Acad.Sci.USA | The Anticoagulant Activation of Antithrombin by Heparin | 266 | 1997 |
| 1E04 | R.Skinner, J.-P.Abrahams, J.C.Whisstock, A.M.Lesk, R.W.Carrell, M.Wardell | 601 | J.Mol.Biol. | The 2.6A Structure of Antithrombin Indicates a Conformational Change at the Heparin Binding Site | 266 | 1997 |
| 1E05 | R.Skinner, J.-P.Abrahams, J.C.Whisstock, A.M.Lesk, R.W.Carrell, M.Wardell | 601 | J.Mol.Biol. | The 2.6A Structure of Antithrombin Indicates a Conformational Change at the Heparin Binding Site | 266 | 1997 |
| 1E0F | J.L.Richardson, B.Kroeger, W.Hoeffken, J.E.Sadler, P.Pereira, R.Huber, W.Bode, P.Fuentes-Prior | 5650 | Embo J. | Crystal Structure of the Human Alpha-Thrombin-Haemadin Complex: An Exosite II-Binding Inhibitor | 19 | 2000 |
| 1EOJ | J.J.Slon-Usakiewicz, J.Sivaraman, Y.Li, M.Cygler, Y.Konishi | 2384 | Biochemistry | Design of P1' and P3' Residues of Trivalent Thrombin Inhibitors and Their Crystal Structures | 39 | 2000 |
| 1EOL | J.J.Slon-Usakiewicz, J.Sivaraman, Y.Li, M.Cygler, Y.Konishi | 2384 | Biochemistry | Design of P1' and P3' Residues of Trivalent Thrombin Inhibitors and Their Crystal Structures | 39 | 2000 |
| 1ETR | H.Brandstetter, D.Turk, H.W.Hoeffken, D.Grosse, J.Sturzebecher, P.D.Martin, B.F.Edwards, W.Bode | 1085 | J Mol Biol | Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. | 226 | 1992 |
| 1ETS | H.Brandstetter, D.Turk, H.W.Hoeffken, D.Grosse, J.Sturzebecher, P.D.Martin, B.F.Edwards, W.Bode | 1085 | J Mol Biol | Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. | 226 | 1992 |
| 1ETT | H.Brandstetter, D.Turk, H.W.Hoeffken, D.Grosse, J.Sturzebecher, P.D.Martin, B.F.Edwards, W.Bode | 1085 | J Mol Biol | Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. | 226 | 1992 |
| 1FPC | I.I.Mathews, A.Tulinsky | 550 | Acta Crystallogr D Biol Crystallogr | ACTIVE-SITE MIMETIC INHIBITION OF THROMBIN. | 51 | 1995 |
| 1FPH | M.T.Stubbs, H.Oschkinat, I.Mayr, R.Huber, H.Angliker, S.R.Stone, W.Bode | 187 | Eur J Biochem | The interaction of thrombin with fibrinogen. A structural basis for its specificity. | 206 | 1992 |
| 1G30 | H.Nar, M.Bauer, A.Schmid, J.Stassen, W.Wienen, H.W.Priepke, I.K.Kauffmann, U.J.Ries, N.H.Hauel | 29 | Structure | Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors | 9 | 2001 |
| 1G32 | H.Nar, M.Bauer, A.Schmid, J.Stassen, W.Wienen, H.W.Priepke, I.K.Kauffmann, U.J.Ries, N.H.Hauel | 29 | Structure | Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors | 9 | 2001 |
| 1G37 | B.Bachand, M.Tarazi, Y.St-Denis, J.J.Edmunds, P.D.Winocour, L.Leblond, M.A.Siddiqui | 287 | Bioorg.Med.Chem.Lett. | Potent and Selective Bicyclic Lactam Inhibitors of Thrombin. Part 4: Transition State Inhibitors | 11 | 2001 |
| 1H8D | E.Skordalakes, G.G.Dodson, D.S.Green, C.A.Goodwin, M.F.Scully, H.R.Hudson, V.V.Kakkar, J.J.Deadman | 549 | J.Mol.Biol. | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate | 311 | 2001 |
| 1H8I | E.Skordalakes, G.G.Dodson, D.S.Green, C.A.Goodwin, M.F.Scully, H.R.Hudson, V.V.Kakkar, J.J.Deadman | 549 | J.Mol.Biol. | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate | 311 | 2001 |
| 1HAG | J.Vijayalakshmi, K.P.Padmanabhan, K.G.Mann, A.Tulinsky | 2254 | Protein Sci | The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. | 3 | 1994 |
| 1HAH | J.Vijayalakshmi, K.P.Padmanabhan, K.G.Mann, A.Tulinsky | 2254 | Protein Sci | The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. | 3 | 1994 |
| 1HAI | J.Vijayalakshmi, K.P.Padmanabhan, K.G.Mann, A.Tulinsky | 2254 | Protein Sci | The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. | 3 | 1994 |
| 1HAO | K.Padmanabhan, A.Tulinsky | 272 | Acta Crystallogr D Biol Crystallogr | An ambiguous structure of a DNA 15-mer thrombin complex. | 52 | 1996 |
| 1HAP | K.Padmanabhan, A.Tulinsky | 272 | Acta Crystallogr D Biol Crystallogr | An ambiguous structure of a DNA 15-mer thrombin complex. | 52 | 1996 |
| 1HBT | P.H.Rehse, T.Steinmetzer, Y.Li, Y.Konishi, M.Cygler | 11537 | Biochemistry | Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin. | 34 | 1995 |
| 1HDT | L.Tabernero, C.Y.Chang, S.L.Ohringer, W.F.Lau, E.J.Iwanowicz, W.C.Han, T.C.Wang, S.M.Seiler, D.G.Roberts, J.S.Sack | 14 | J Mol Biol | Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin. | 246 | 1995 |
| 1HGT | E.Skrzypczak-Jankun, V.E.Carperos, K.G.Ravichandran, A.Tulinsky, M.Westbrook, J.M.Maraganore | 1379 | J Mol Biol | Structure of the hirugen and hirulog 1 complexes of alpha-thrombin. | 221 | 1991 |
| 1HLT | I.I.Mathews, K.P.Padmanabhan, A.Tulinksy, J.E.Sadler | 13547 | Biochemistry | Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin. | 33 | 1994 |
| 1HRT | J.Vitali, P.D.Martin, M.G.Malkowski, W.D.Robertson, J.B.Lazar, R.C.Winant, P.H.Johnson, B.F.Edwards | 17670 | J Biol Chem | The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution. | 267 | 1992 |
| 1HUT | K.Padmanabhan, K.P.Padmanabhan, J.D.Ferrara, J.E.Sadler, A.Tulinsky | 17651 | J Biol Chem | The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer. | 268 | 1993 |
| 1HXE | E.Zhang, A.Tulinsky | 185 | Biophys Chem | The molecular environment of the Na+ binding site of thrombin. | 63 | 1997 |
| 1HXF | E.Zhang, A.Tulinsky | 185 | Biophys Chem | The molecular environment of the Na+ binding site of thrombin. | 63 | 1997 |
| 1ID5 | S.X.Wang, C.T.Esmon, R.J.Fletterick | 10038 | Biochemistry | Crystal Structure of Thrombin-Ecotin Reveals Conformational Changes and Extended Interactions | 40 | 2001 |
| 1IHS | A.Zdanov, S.Wu, J.DiMaio, Y.Konishi, Y.Li, X.Wu, B.F.Edwards, P.D.Martin, M.Cygler | 252 | Proteins | Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6. | 17 | 1993 |
| 1IHT | A.Zdanov, S.Wu, J.DiMaio, Y.Konishi, Y.Li, X.Wu, B.F.Edwards, P.D.Martin, M.Cygler | 252 | Proteins | Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6. | 17 | 1993 |
| 1JOU | J.A.Huntington, C.T.Esmon | n/a | To be Published | 1.8A Structure of Native S195A Thrombin with an Unoccupied Active Site-Implications for Substrate Recognition | n/a | n/a |
| 1LHC | P.C.Weber, S.L.Lee, F.A.Lewandowski, M.C.Schadt, C.W.Chang, C.A.Kettner | 3750 | Biochemistry | Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. | 34 | 1995 |
| 1LHD | P.C.Weber, S.L.Lee, F.A.Lewandowski, M.C.Schadt, C.W.Chang, C.A.Kettner | 3750 | Biochemistry | Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. | 34 | 1995 |
| 1LHE | P.C.Weber, S.L.Lee, F.A.Lewandowski, M.C.Schadt, C.W.Chang, C.A.Kettner | 3750 | Biochemistry | Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. | 34 | 1995 |
| 1LHF | P.C.Weber, S.L.Lee, F.A.Lewandowski, M.C.Schadt, C.W.Chang, C.A.Kettner | 3750 | Biochemistry | Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. | 34 | 1995 |
| 1LHG | P.C.Weber, S.L.Lee, F.A.Lewandowski, M.C.Schadt, C.W.Chang, C.A.Kettner | 3750 | Biochemistry | Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. | 34 | 1995 |
| 1MKW | M.G.Malkowski, P.D.Martin, J.C.Guzik, B.F.Edwards | 1438 | Protein Sci | The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding. | 6 | 1997 |
| 1MKX | M.G.Malkowski, P.D.Martin, J.C.Guzik, B.F.Edwards | 1438 | Protein Sci | The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding. | 6 | 1997 |
| 1NRN | I.I.Mathews, K.P.Padmanabhan, V.Ganesh, A.Tulinsky, M.Ishii, J.Chen, C.W.Turck, S.R.Coughlin, .2.Fenton 2nd | 3266 | Biochemistry | Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. | 33 | 1994 |
| 1NRO | I.I.Mathews, K.P.Padmanabhan, V.Ganesh, A.Tulinsky, M.Ishii, J.Chen, C.W.Turck, S.R.Coughlin, .2.Fenton 2nd | 3266 | Biochemistry | Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. | 33 | 1994 |
| 1NRP | I.I.Mathews, K.P.Padmanabhan, V.Ganesh, A.Tulinsky, M.Ishii, J.Chen, C.W.Turck, S.R.Coughlin, .2.Fenton 2nd | 3266 | Biochemistry | Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. | 33 | 1994 |
| 1NRQ | I.I.Mathews, K.P.Padmanabhan, V.Ganesh, A.Tulinsky, M.Ishii, J.Chen, C.W.Turck, S.R.Coughlin, .2.Fenton 2nd | 3266 | Biochemistry | Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. | 33 | 1994 |
| 1NRR | I.I.Mathews, K.P.Padmanabhan, V.Ganesh, A.Tulinsky, M.Ishii, J.Chen, C.W.Turck, S.R.Coughlin, .2.Fenton 2nd | 3266 | Biochemistry | Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. | 33 | 1994 |
| 1NRS | I.I.Mathews, K.P.Padmanabhan, V.Ganesh, A.Tulinsky, M.Ishii, J.Chen, C.W.Turck, S.R.Coughlin, .2.Fenton 2nd | 3266 | Biochemistry | Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. | 33 | 1994 |
| 1PPB | W.Bode, I.Mayr, U.Baumann, R.Huber, S.R.Stone, J.Hofsteenge | 3467 | EMBO J | The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. | 8 | 1989 |
| 1QBV | R.Bone, T.Lu, C.R.Illig, R.M.Soll, J.C.Spurlino | 2068 | J.Med.Chem. | Structural Analysis of Thrombin Complexed with Potent Inhibitors Incorporating a Phenyl Group as a Peptide Mimetic and Aminopyridines as Guanidine Substitutes. | 41 | 1998 |
| 1QHR | H.Jhoti, A.Cleasby, S.Reid, P.Thomas, M.Weir, A.Wonacott | 7969 | Biochemistry | Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-Trans-Lactone Template | 38 | 1999 |
| 1QJ1 | H.Jhoti, A.Cleasby, S.Reid, P.Thomas, M.Weir, A.Wonacott | 7969 | Biochemistry | Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-Trans-Lactone Template | 38 | 1999 |
| 1QJ6 | H.Jhoti, A.Cleasby, S.Reid, P.Thomas, M.Weir, A.Wonacott | 7969 | Biochemistry | Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-Trans-Lactone Template | 38 | 1999 |
| 1QJ7 | H.Jhoti, A.Cleasby, S.Reid, P.Thomas, M.Weir, A.Wonacott | 7969 | Biochemistry | Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-Trans-Lactone Template | 38 | 1999 |
| 1QUR | T.Steinmetzer, M.Renatus, S.Kuenzel, A.Eichinger, W.Bode, P.Wikstroem, J.Hauptmann, J.Stuerzebecher | 598 | Eur.J.Biochem. | Design and Evaluation of Novel Bivalent Thrombin Inhibitors Based on Amidinophenylalanines | 265 | 1999 |
| 1TBQ | A.van de Locht, D.Lamba, M.Bauer, R.Huber, T.Friedrich, B.Kroger, W.Hoffken, W.Bode | 5149 | EMBO J | Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. | 14 | 1995 |
| 1TBR | A.van de Locht, D.Lamba, M.Bauer, R.Huber, T.Friedrich, B.Kroger, W.Hoffken, W.Bode | 5149 | EMBO J | Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. | 14 | 1995 |
| 1THP | E.R.Guinto, S.Caccia, T.Rose, K.Futterer, G.Waksman, E.Di Cera | 1852 | Proc Natl Acad Sci U S A | Unexpected crucial role of residue 225 in serine proteases. | 96 | 1999 |
| 1THR | X.Qiu, M.Yin, K.P.Padmanabhan, J.L.Krstenansky, A.Tulinsky | 20318 | J Biol Chem | Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor. | 268 | 1993 |
| 1THS | X.Qiu, M.Yin, K.P.Padmanabhan, J.L.Krstenansky, A.Tulinsky | 20318 | J Biol Chem | Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor. | 268 | 1993 |
| 1TMB | B.E.Maryanoff, X.Qiu, K.P.Padmanabhan, A.Tulinsky, H.R.Almond Jr., P.Andrade-Gordon, M.N.Greco, J.A.Kauffman, K.C.Nicolaou, A.Liu, et al. | 8048 | Proc Natl Acad Sci U S A | Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. | 90 | 1993 |
| 1TMT | J.P.Priestle, J.Rahuel, H.Rink, M.Tones, M.G.Grutter | 1630 | Protein Sci | Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. | 2 | 1993 |
| 1TMU | J.P.Priestle, J.Rahuel, H.Rink, M.Tones, M.G.Grutter | 1630 | Protein Sci | Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. | 2 | 1993 |
| 1TOC | A.van de Locht, M.T.Stubbs, W.Bode, T.Friedrich, C.Bollschweiler, W.Hoffken, R.Huber | 6011 | EMBO J | The ornithodorin-thrombin crystal structure, a key to the TAP enigma? | 15 | 1996 |
| 1UCY | P.D.Martin, M.G.Malkowski, J.DiMaio, Y.Konishi, F.Ni, B.F.Edwards | 13030 | Biochemistry | Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues. | 35 | 1996 |
| 1UMA | M.Nardini, A.Pesce, M.Rizzi, E.Casale, R.Ferraccioli, G.Balliano, P.Milla, P.Ascenzi, M.Bolognesi | 851 | J Mol Biol | Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study. | 258 | 1996 |
| 1UVS | R.A.Engh, H.Brandstetter, G.Sucher, A.Eichinger, U.Baumann, W.Bode, R.Huber, T.Poll, R.Rudolph, W.von der Saal | 1353 | Structure | Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design. | 4 | 1996 |
| 1UVT | R.A.Engh, H.Brandstetter, G.Sucher, A.Eichinger, U.Baumann, W.Bode, R.Huber, T.Poll, R.Rudolph, W.von der Saal | 1353 | Structure | Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design. | 4 | 1996 |
| 1UVU | R.A.Engh, H.Brandstetter, G.Sucher, A.Eichinger, U.Baumann, W.Bode, R.Huber, T.Poll, R.Rudolph, W.von der Saal | 1353 | Structure | Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design. | 4 | 1996 |
| 1VIT | J.Vitali, P.D.Martin, M.G.Malkowski, C.M.Olsen, P.H.Johnson, B.F.P.Edwards | 453 | Acta Crystallogr D Biol Crystallogr | Structure of a bovine thrombin-hirudin(51-65) complex determined by a combination of molecular replacement and graphics. Incorporation of known structural information in molecular replacement. | 52 | 1996 |
| 1VR1 | R.J.Dekker, A.Eichinger, A.A.Stoop, W.Bode, H.Pannekoek, A.J.G.Horrevoets | 613 | J.Mol.Biol. | The Variable Region-1 from Tissue-Type Plasminogen Activator Confers Specificity for Plasminogen Activator Inhibitor-1 to Thrombin by Facilitating Catalysis: Release of a Kinetic Block by a Heterologous Protein Surface Loop | 293 | 1999 |
| 1YCP | M.G.Malkowski, P.D.Martin, S.T.Lord, B.F.Edwards | 815 | Biochem J | Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16. | 326 | 1997 |
| 2ANT | R.Skinner, J.P.Abrahams, J.C.Whisstock, A.M.Lesk, R.W.Carrell, M.R.Wardell | 601 | J.Mol.Biol. | The 2.6 A Structure of Antithrombin Indicates a Conformational Change at the Heparin Binding Site | 266 | 1997 |
| 2HGT | E.Skrzypczak-Jankun, V.E.Carperos, K.G.Ravichandran, A.Tulinsky, M.Westbrook, J.M.Maraganore | 1379 | J Mol Biol | Structure of the hirugen and hirulog 1 complexes of alpha-thrombin. | 221 | 1991 |
| 2HNT | T.J.Rydel, M.Yin, K.P.Padmanabhan, D.T.Blankenship, A.D.Cardin, P.E.Correa, .2.Fenton 2nd, A.Tulinsky | 22000 | J Biol Chem | Crystallographic structure of human gamma-thrombin. | 269 | 1994 |
| 2HPP | R.K.Arni, K.Padmanabhan, K.P.Padmanabhan, T.P.Wu, A.Tulinsky | 4727 | Biochemistry | Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin. | 32 | 1993 |
| 2HPQ | R.K.Arni, K.Padmanabhan, K.P.Padmanabhan, T.P.Wu, A.Tulinsky | 4727 | Biochemistry | Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin. | 32 | 1993 |
| 2PF1 | T.P.Seshadri, A.Tulinsky, E.Skrzypczak-Jankun, C.H.Park | 481 | J Mol Biol | Structure of bovine prothrombin fragment 1 refined at 2.25 A resolution. | 220 | 1991 |
| 2PF2 | M.Soriano-Garcia, K.Padmanabhan, A.M.de Vos, A.Tulinsky | 2554 | Biochemistry | The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1. | 31 | 1992 |
| 2SPT | T.P.Seshadri, E.Skrzypczak-Jankun, M.Yin, A.Tulinsky | 1087 | Biochemistry | Differences in the metal ion structure between Sr- and Ca-prothrombin fragment 1. | 33 | 1994 |
| 2THF | E.R.Guinto, S.Caccia, T.Rose, K.Futterer, G.Waksman, E.Di Cera | 1852 | Proc Natl Acad Sci U S A | Unexpected crucial role of residue 225 in serine proteases. | 96 | 1999 |
| 3HAT | I.I.Mathews, A.Tulinsky | n/a | To be Published | Active Site Mimetic Inhibition of Thrombin | n/a | n/a |
| 3HTC | T.Rydel, K.G.Ravichandran, A.Tulinsky, W.Bode, R.Huber, C.Roitsch, J.W.Fenton /II | 277 | Science | The Structure of a Complex of Recombinant Hirudin and Human Alpha-Thrombin | 249 | 1990 |
| 4HTC | T.J.Rydel, A.Tulinsky, W.Bode, R.Huber | 583 | J.Mol.Biol. | The Refined Structure of the Hirudin-Thrombin Complex | 221 | 1991 |
| 4THN | A.Lombardi, G.De Simone, F.Nastri, S.Galdiero, R.Della Morte, N.Staiano, C.Pedone, M.Bolognesi, V.Pavone | 91 | Protein Sci. | The Crystal Structure of Alpha-Thrombin-Hirunorm Iv Complex Reveals a Novel Specificity Site Recognition Mode | 8 | 1999 |
| 5GDS | G.De Simone, A.Lombardi, S.Galdiero, F.Nastri, R.Della Morte, N.Staiano, C.Pedone, M.Bolognesi, V.Pavone | 243 | Protein Sci | Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex. | 7 | 1998 |
| 7KME | I.Mochalkin, A.Tulinsky | 785 | Acta Crystallogr D Biol Crystallogr | Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding. | 55 | 1999 |
| 8KME | I.Mochalkin, A.Tulinsky | n/a | To be Published | Crystal Structures of Thrombin Retror-Inhibited with Sel2711 and Sel2770 as They Relate to Factor Xa Binding | n/a | n/a |
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