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Aminoacyl-tRNA Synthetase

Primary Citation
PDB_ID Authors Title Publication Volume_No First_Page Year
1ADJ A.Aberg, A.Yaremchuk, M.Tukalo, B.Rasmussen, S.Cusack Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase. Biochemistry 36 3084 1997
1ADY A.Aberg, A.Yaremchuk, M.Tukalo, B.Rasmussen, S.Cusack Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase. Biochemistry 36 3084 1997
1B70 L.Reshetnikova, N.Moor, O.Lavrik, D.G.Vassylyev Crystal Structures of Phenylalanyl-tRNA Synthetase Complexed with Phenylalanine and a Phenylalanyl-Adenylate Analogue J.Mol.Biol. 287 555 1999
1B76 J.G.Arnez, A.C.Dock-Bregeon, D.Moras Glycyl-tRNA synthetase uses a negatively charged pit for specific recognition and activation of glycine. J Mol Biol 286 1449 1999
1B7Y L.Reshetnikova, N.Moor, O.Lavrik, D.G.Vassylyev Crystal Structures of Phenylalanyl-tRNA Synthetase Complexed with Phenylalanine and a Phenylalanyl-Adenylate Analogue J.Mol.Biol. 287 555 1999
1B8A E.Schmitt, L.Moulinier, S.Fujiwara, T.Imanaka, J.C.Thierry, D.Moras Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation. EMBO J 17 5227 1998
1BS2 J.Cavarelli, B.Delagoutte, G.Eriani, J.Gangloff, D.Moras L-Arginine Recognition by Yeast Arginyl-tRNA Synthetase Embo J. 17 5438 1998
1C0A S.Eiler, A.-C.Dock-Bregeon, L.Moulinier, J.-C.Thierry, D.Moras Synthesis of Aspartyl-tRNA(Asp) in Escherichia Coli-A Snapshot of the Second Step Embo J. 18 6532 1999
1D2R V.A.Ilyin, B.Temple, G.-P.Li, Y.P.Vachette, C.W.Carter Jr. 2.9 A Crystal Structure of Ligand-Free Tryptophanyl-tRNA Synthetase: Domain Movements Fragment the Adenine Nucleotide Binding Site. Protein Sci. 9 218 2000
1EFW C.Briand, A.Poterszman, S.Eiler, G.Webster, J.-C.Thierry, D.Moras An Intermediate Step in the Recognition of tRNA(Asp) by Aspartyl-tRNA Synthetase J.Mol.Biol. 299 1051 2000
1EIY Y.Goldgur, L.Mosyak, L.Reshetnikova, V.Ankilova, M.Safro The Crystal Structure of Phenylalanyl-tRNA Synthetase from Thermus Thermophilus Complexed with Cognate tRNAphe Structure 5 59 1997
1EQR B.Rees, G.Webster, M.Delarue, M.Boeglin, D.Moras Aspartyl tRNA-Synthetase from Escherichia Coli: Flexibility and Adaptability to the Substrates J.Mol.Biol. 299 1157 2000
1EUQ L.D.Sherlin, T.L.Bullock, K.J.Newberry, R.S.A.Lipman, Y.-M.Hou, B.Beijer, B.S.Sproat, J.J.Perona Crystal Structure Of Glutaminyl-tRNA Synthetase Complexed With A tRNA-Gln Mutant and An Active-Site Inhibitor J.Mol.Biol. 299 431 2000
1EUY L.D.Sherlin, T.L.Bullock, K.J.Newberry, R.S.A.Lipman, Y.-M.Hou, B.Beijer, B.S.Sproat, J.J.Perona Glutaminyl-tRNA Synthetase Complexed With A tRNA Mutant and An Active Site Inhibitor J.Mol.Biol. 299 431 2000
1EXD T.L.Bullock, L.D.Sherlin, J.J.Perona Tertiary Core Rearrangements in a Tight Binding Transfer RNA Aptamer Nat.Struct.Biol. 7 497 2000
1G51 A.Poterzsman, M.Delarue, J.C.Thierry, D.Moras Synthesis and Recognition of Aspartyl-Adenylate by Thermus Thermophilus Aspartyl-tRNA Synthetase J.Mol.Biol. 244 158 1994
1GAX S.Fukai, O.Nureki, S.Sekine, A.Shimada, J.Tao, D.G.Vassylyev, S.Yokoyama Structural Basis for Double-Sieve Discrimination of L-Valine from L-Isoleucine and L-Threonine by the Complex of tRNA(Val) and Valyl-tRNA Synthetase Cell (Cambridge,Mass.) 103 793 2000
1GGM J.G.Arnez, A.C.Dock-Bregeon, D.Moras Glycyl-tRNA synthetase uses a negatively charged pit for specific recognition and activation of glycine. J Mol Biol 286 1449 1999
1GLN O.Nureki, D.G.Vassylyev, K.Katayanagi, T.Shimizu, S.Sekine, T.Kigawa, T.Miyazawa, S.Yokoyama, K.Morikawa Architectures of class-defining and specific domains of glutamyl-tRNA synthetase. Science 267 1958 1995
1GSG M.A.Rould, J.J.Perona, D.Soll, T.A.Steitz Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution. Science 246 1135 1989
1GTR M.A.Rould, J.J.Perona, T.A.Steitz Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase. Nature 352 213 1991
1GTS J.J.Perona, M.A.Rould, T.A.Steitz Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase. Biochemistry 32 8758 1993
1HTT J.G.Arnez, D.C.Harris, A.Mitschler, B.Rees, C.S.Francklyn, D.Moras Crystal structure of histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylate. EMBO J 14 4143 1995
1KMM J.G.Arnez, J.G.Augustine, D.Moras, C.S.Francklyn The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase. Proc Natl Acad Sci U S A 94 7144 1997
1KMN J.G.Arnez, J.G.Augustine, D.Moras, C.S.Francklyn The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase. Proc Natl Acad Sci U S A 94 7144 1997
1PYS L.Mosyak, L.Reshetnikova, Y.Goldgur, M.Delarue, M.G.Safro Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus. Nat Struct Biol 2 537 1995
1QE0 X.Qiu, C.A.Janson, M.N.Blackburn, I.K.Chohan, M.Hibbs, S.S.Abdel-Meguid Cooperative Structural Dynamics and a Novel Fidelity Mechanism in Histidyl- tRNA Synthetases Biochemistry 38 12296 1999
1QRS J.G.Arnez, T.A.Steitz Crystal structures of three misacylating mutants of Escherichia coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP. Biochemistry 35 14725 1996
1QRT J.G.Arnez, T.A.Steitz Crystal structures of three misacylating mutants of Escherichia coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP. Biochemistry 35 14725 1996
1QRU J.G.Arnez, T.A.Steitz Crystal structures of three misacylating mutants of Escherichia coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP. Biochemistry 35 14725 1996
1QTQ V.L.Rath, L.F.Silvian, B.Beijer, B.S.Sproat, T.A.Steitz How glutaminyl-tRNA synthetase selects glutamine. Structure 6 439 1998
1SER V.Biou, A.Yaremchuk, M.Tukalo, S.Cusack The 2.9 A crystal structure of T. thermophilus seryl-tRNA synthetase complexed with tRNA(Ser). Science 263 1404 1994
1SES H.Belrhali, A.Yaremchuk, M.Tukalo, K.Larsen, C.Berthet-Colominas, R.Leberman, B.Beijer, B.Sproat, J.Als-Nielsen, G.Grubel, et al. Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate. Science 263 1432 1994
1SET H.Belrhali, A.Yaremchuk, M.Tukalo, K.Larsen, C.Berthet-Colominas, R.Leberman, B.Beijer, B.Sproat, J.Als-Nielsen, G.Grubel, et al. Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate. Science 263 1432 1994
1SRY M.Fujinaga, C.Berthet-Colominas, A.D.Yaremchuk, M.A.Tukalo, S.Cusack Refined crystal structure of the seryl-tRNA synthetase from Thermus thermophilus at 2.5 A resolution. J Mol Biol 234 222 1993
1TYA K.A.Brown, P.De Meester, A.R.Fersht II, D.M.Blow Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions To be Published n/a n/a n/a
1TYB K.A.Brown, P.De Meester, A.R.Fersht II, D.M.Blow Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions To be Published n/a n/a n/a
1TYC K.A.Brown, P.De Meester, A.R.Fersht II, D.M.Blow Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions To be Published n/a n/a n/a
1TYD P.Brick, T.N.Bhat, D.M.Blow Structure of Tyrosyl-tRNA Synthetase Refined at 2.3 Angstroms Resolution. Interaction of the Enzyme with the Tyrosyl Adenylate Intermediate J.Mol.Biol. 208 83 1989
2TS1 P.Brick, T.N.Bhat, D.M.Blow Structure of Tyrosyl-tRNA Synthetase Refined at 2.3 Angstroms Resolution. Interaction of the Enzyme with the Tyrosyl Adenylate Intermediate J.Mol.Biol. 208 83 1989
3TS1 P.Brick, T.N.Bhat, D.M.Blow Structure of Tyrosyl-tRNA Synthetase Refined at 2.3 Angstroms Resolution. Interaction of the Enzyme with the Tyrosyl Adenylate Intermediate J.Mol.Biol. 208 83 1989
4TS1 P.Brick, D.M.Blow Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine. J Mol Biol 194 287 1987

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PDB Molecule of the Month April 2001, by David S. Goodsell

Last changed by: A.Honegger, 8/4/06