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Lactate Dehydrogenase

A list of lactate dehydrogenase related entries in the PDB

as determined by a keyword search on May 14, 2008

Structure ID  Title Authors Publication Year Journal Name Volume ID First Page Pubmed
1A5Z Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization. Auerbach, G., Ostendorp, R., Prade, L., Korndorfer, I., Dams, T., Huber, R., Jaenicke, R. 1998 Structure 6 769 9655830
1CEQ Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase. Read, J.A., Wilkinson, K.W., Tranter, R., Sessions, R.B., Brady, R.L. 1999 J.Biol.Chem. 274 10213 10187806
1CET Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase. Read, J.A., Wilkinson, K.W., Tranter, R., Sessions, R.B., Brady, R.L. 1999 J.Biol.Chem. 274 10213 10187806
1DXY Crystal structure of a ternary complex of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, NAD+ and 2-oxoisocaproate at 1.9 A resolution. Dengler, U., Niefind, K., Kiess, M., Schomburg, D. 1997 J.Mol.Biol. 267 640 9126843
1EZ4 Crystal structure of non-allosteric L-lactate dehydrogenase from Lactobacillus pentosus at 2.3 A resolution: specific interactions at subunit interfaces. Uchikoba, H., Fushinobu, S., Wakagi, T., Konno, M., Taguchi, H., Matsuzawa, H. 2002 Proteins 46 206 11807949
1F0X The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme. Dym, O., Pratt, E.A., Ho, C., Eisenberg, D. 2000 Proc.Natl.Acad.Sci.USA 97 9413 10944213
1GPD Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase. Moras, D., Olsen, K.W., Sabesan, M.N., Buehner, M., Ford, G.C., Rossmann, M.G. 1975 J.Biol.Chem. 250 9137 127793
1HYH Crystal structure of L-2-hydroxyisocaproate dehydrogenase from Lactobacillus confusus at 2.2 A resolution. An example of strong asymmetry between subunits. Niefind, K., Hecht, H.J., Schomburg, D. 1995 J.Mol.Biol. 251 256 7643402
1I0Z Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Read, J.A., Winter, V.J., Eszes, C.M., Sessions, R.B., Brady, R.L. 2001 Proteins 43 175 11276087
1I10 Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Read, J.A., Winter, V.J., Eszes, C.M., Sessions, R.B., Brady, R.L. 2001 Proteins 43 175 11276087
1J49 Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus. Razeto, A., Kochhar, S., Hottinger, H., Dauter, M., Wilson, K.S., Lamzin, V.S. 2002 J.Mol.Biol. 318 109 12054772
1J4A Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus. Razeto, A., Kochhar, S., Hottinger, H., Dauter, M., Wilson, K.S., Lamzin, V.S. 2002 J.Mol.Biol. 318 109 12054772
1LCO X-ray structure of two complexes of the Y143F flavocytochrome b2 mutant crystallized in the presence of lactate or phenyl lactate. Tegoni, M., Begotti, S., Cambillau, C. 1995 Biochemistry 34 9840 7632684
1LDB Structure determination and refinement of Bacillus stearothermophilus lactate dehydrogenase. Piontek, K., Chakrabarti, P., Schar, H.P., Rossmann, M.G., Zuber, H. 1990 Proteins 7 74 2330370
1LDC X-ray structure of two complexes of the Y143F flavocytochrome b2 mutant crystallized in the presence of lactate or phenyl lactate. Tegoni, M., Begotti, S., Cambillau, C. 1995 Biochemistry 34 9840 7632684
1LDG The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design. Dunn, C.R., Banfield, M.J., Barker, J.J., Higham, C.W., Moreton, K.M., Turgut-Balik, D., Brady, R.L., Holbrook, J.J. 1996 Nat.Struct.Biol. 3 912 8901865
1LDM Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. Abad-Zapatero, C., Griffith, J.P., Sussman, J.L., Rossmann, M.G. 1987 J.Mol.Biol. 198 445 3430615
1LDN Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2.5 A resolution. Wigley, D.B., Gamblin, S.J., Turkenburg, J.P., Dodson, E.J., Piontek, K., Muirhead, H., Holbrook, J.J. 1992 J.Mol.Biol. 223 317 1731077
1LLC STRUCTURE DETERMINATION OF THE ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS-CASEI AT 3A RESOLUTION. Buehner, M., Hecht, H.J. 1984 Acta Crystallogr.,Sect.A 40 32 -1
1LLD Molecular basis of allosteric activation of bacterial L-lactate dehydrogenase. Iwata, S., Ohta, T. 1993 J.Mol.Biol. 230 21 8450537
1LTH T and R states in the crystals of bacterial L-lactate dehydrogenase reveal the mechanism for allosteric control. Iwata, S., Kamata, K., Yoshida, S., Minowa, T., Ohta, T. 1994 Nat.Struct.Biol. 1 176 7656036
1OC4 Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus. Winter, V.J., Cameron, A., Tranter, R., Sessions, R.B., Brady, R.L. 2003 Mol.Biochem.Parasitol. 131 1 12967707
1PZE Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use. Kavanagh, K.L., Elling, R.A., Wilson, D.K. 2004 Biochemistry 43 879 14744130
1PZF Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use. Kavanagh, K.L., Elling, R.A., Wilson, D.K. 2004 Biochemistry 43 879 14744130
1PZG Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use. Kavanagh, K.L., Elling, R.A., Wilson, D.K. 2004 Biochemistry 43 879 14744130
1PZH Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use. Kavanagh, K.L., Elling, R.A., Wilson, D.K. 2004 Biochemistry 43 879 14744130
1Q74 The Crystal Structure of 1-D-myo-Inosityl 2-Acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB) from Mycobacterium tuberculosis Reveals a Zinc Hydrolase with a Lactate Dehydrogenase Fold. Maynes, J.T., Garen, C., Cherney, M.M., Newton, G., Arad, D., Av-Gay, Y., Fahey, R.C., James, M.N. 2003 J.Biol.Chem. 278 47166 12945769
1QCW Kinetic and crystallographic studies on the active site Arg289Lys mutant of flavocytochrome b2 (yeast L-lactate dehydrogenase) Mowat, C.G., Beaudoin, I., Durley, R.C.E., Barton, J.D., Pike, A.D., Chen, Z.-W., Reid, G.A., Chapman, S.K., Mathews, F.S., Lederer, F. 2000 Biochemistry 39 3266 10727218
1R5J Crystal structure of a phosphotransacetylase from Streptococcus pyogenes. Xu, Q.S., Shin, D.H., Pufan, R., Yokota, H., Kim, R., Kim, S.H. 2004 Proteins 55 479 15048838
1SOV Structure of apo and ternary forms of Toxoplasma gondii LDH2 Kavanagh, K.L., Wilson, D.K. n/a To be Published n/a n/a n/a
1SOW Structure of apo and ternary forms of Toxoplasma gondii LDH2 Kavanagh, K.L., Wilson, D.K. n/a To be Published n/a n/a n/a
1SZE Altered Substrate Specificity in Flavocytochrome b(2): Structural Insights into the Mechanism of l-Lactate Dehydrogenation Mowat, C.G., Wehenkel, A., Green, A.J., Walkinshaw, M.D., Reid, G.A., Chapman, S.K. 2004 Biochemistry 43 9519 15260495
1SZF Altered Substrate Specificity in Flavocytochrome b(2): Structural Insights into the Mechanism of l-Lactate Dehydrogenation Mowat, C.G., Wehenkel, A., Green, A.J., Walkinshaw, M.D., Reid, G.A., Chapman, S.K. 2004 Biochemistry 43 9519 15260495
1SZG Altered Substrate Specificity in Flavocytochrome b(2): Structural Insights into the Mechanism of l-Lactate Dehydrogenation Mowat, C.G., Wehenkel, A., Green, A.J., Walkinshaw, M.D., Reid, G.A., Chapman, S.K. 2004 Biochemistry 43 9519 15260495
1T24 Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. Cameron, A., Read, J., Tranter, R., Winter, V.J., Sessions, R.B., Brady, R.L., Vivas, L., Easton, A., Kendrick, H., Croft, S.L., Barros, D., Lavandera, J.L., Martin, J.J., Risco, F., Garcia-Ochoa, S., Gamo, F.J., Sanz, L., Leon, L., Ruiz, J.R., Gabarro, R., Mallo, A., De Las Heras, F.G. 2004 J.Biol.Chem. 279 31429 15117937
1T25 Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. Cameron, A., Read, J., Tranter, R., Winter, V.J., Sessions, R.B., Brady, R.L., Vivas, L., Easton, A., Kendrick, H., Croft, S.L., Barros, D., Lavandera, J.L., Martin, J.J., Risco, F., Garcia-Ochoa, S., Gamo, F.J., Sanz, L., Leon, L., Ruiz, J.R., Gabarro, R., Mallo, A., De Las Heras, F.G. 2004 J.Biol.Chem. 279 31429 15117937
1T26 Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. Cameron, A., Read, J., Tranter, R., Winter, V.J., Sessions, R.B., Brady, R.L., Vivas, L., Easton, A., Kendrick, H., Croft, S.L., Barros, D., Lavandera, J.L., Martin, J.J., Risco, F., Garcia-Ochoa, S., Gamo, F.J., Sanz, L., Leon, L., Ruiz, J.R., Gabarro, R., Mallo, A., De Las Heras, F.G. 2004 J.Biol.Chem. 279 31429 15117937
1T2C Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. Cameron, A., Read, J., Tranter, R., Winter, V.J., Sessions, R.B., Brady, R.L., Vivas, L., Easton, A., Kendrick, H., Croft, S.L., Barros, D., Lavandera, J.L., Martin, J.J., Risco, F., Garcia-Ochoa, S., Gamo, F.J., Sanz, L., Leon, L., Ruiz, J.R., Gabarro, R., Mallo, A., De Las Heras, F.G. 2004 J.Biol.Chem. 279 31429 15117937
1T2D Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. Cameron, A., Read, J., Tranter, R., Winter, V.J., Sessions, R.B., Brady, R.L., Vivas, L., Easton, A., Kendrick, H., Croft, S.L., Barros, D., Lavandera, J.L., Martin, J.J., Risco, F., Garcia-Ochoa, S., Gamo, F.J., Sanz, L., Leon, L., Ruiz, J.R., Gabarro, R., Mallo, A., De Las Heras, F.G. 2004 J.Biol.Chem. 279 31429 15117937
1T2E Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. Cameron, A., Read, J., Tranter, R., Winter, V.J., Sessions, R.B., Brady, R.L., Vivas, L., Easton, A., Kendrick, H., Croft, S.L., Barros, D., Lavandera, J.L., Martin, J.J., Risco, F., Garcia-Ochoa, S., Gamo, F.J., Sanz, L., Leon, L., Ruiz, J.R., Gabarro, R., Mallo, A., De Las Heras, F.G. 2004 J.Biol.Chem. 279 31429 15117937
1T2F Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. Cameron, A., Read, J., Tranter, R., Winter, V.J., Sessions, R.B., Brady, R.L., Vivas, L., Easton, A., Kendrick, H., Croft, S.L., Barros, D., Lavandera, J.L., Martin, J.J., Risco, F., Garcia-Ochoa, S., Gamo, F.J., Sanz, L., Leon, L., Ruiz, J.R., Gabarro, R., Mallo, A., De Las Heras, F.G. 2004 J.Biol.Chem. 279 31429 15117937
1U4O Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. Conners, R., Schambach, F., Read, J., Cameron, A., Sessions, R.B., Vivas, L., Easton, A., Croft, S.L., Brady, R.L. 2005 Mol.Biochem.Parasitol. 142 137 15978953
1U4S Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. Conners, R., Schambach, F., Read, J., Cameron, A., Sessions, R.B., Vivas, L., Easton, A., Croft, S.L., Brady, R.L. 2005 Mol.Biochem.Parasitol. 142 137 15978953
1U5A Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. Conners, R., Schambach, F., Read, J., Cameron, A., Sessions, R.B., Vivas, L., Easton, A., Croft, S.L., Brady, R.L. 2005 Mol.Biochem.Parasitol. 142 137 15978953
1U5C Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. Conners, R., Schambach, F., Read, J., Cameron, A., Sessions, R.B., Vivas, L., Easton, A., Croft, S.L., Brady, R.L. 2005 Mol.Biochem.Parasitol. 142 137 15978953
1V6A Crystal Structure of L-lactate dehydrogenase from Cyprinus carpio Watanabe, K., Motoshima, H. n/a To be Published n/a n/a n/a
1VBI Crystal structure of type 2 malate/lactate dehydrogenase from thermus thermophilus HB8 Mizutani, H., Kunishima, N. n/a To be Published n/a n/a n/a
1X0A Crystal Structure of type II malate/lactate dehydrogenase from thermus thermophilus HB8 Mizutani, H., Kunishima, N. n/a To be Published n/a n/a n/a
1XIV Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase Conners, R., Schambach, F., Read, J.A., Cameron, A., Sessions, R.B., Vivas, L., Easton, A., Croft, S.L., Brady, R.L. 2005 MOL.BIOCHEM.PARASITOL. 142 137 15978953
1Y6J L-Lactate Dehydrogenase from Clostridium Thermocellum Cth-1135 Chen, L., Yang, H., Kataeva, I., Chen, L.R., Tempel, W., Lee, D., Habel, J., Zhou, W., Lin, D., Ljungdahl, L., Liu, Z.-J., Rose, J., Wang, B.-C. n/a To be Published n/a n/a n/a
2A92 Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH. Chaikuad, A., Fairweather, V., Conners, R., Joseph-Horne, T., Turgut-Balik, D., Brady, R.L. 2005 Biochemistry 44 16221 16331982
2A94 Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH. Chaikuad, A., Fairweather, V., Conners, R., Joseph-Horne, T., Turgut-Balik, D., Brady, R.L. 2005 Biochemistry 44 16221 16331982
2AA3 Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH. Chaikuad, A., Fairweather, V., Conners, R., Joseph-Horne, T., Turgut-Balik, D., Brady, R.L. 2005 Biochemistry 44 16221 16331982
2DLD Dehydrogenases Engineering to Correct Substrate Inhibition in a Commercial Dehydrogenase Bernard, N., Delcour, J., Alvarez, A., Cortes, A., Willis, C., Holbrook, J.J. n/a To be Published n/a n/a n/a
2E37 Structure of TT0471 protein from Thermus thermophilus Lokanath, N.K., Kunishima, N. n/a To be Published n/a n/a n/a
2EWD Structure of Cryptosporidium parvum Lactate Dehydrogenase in complex with substrates and cofactors Senkovich, O.A., Chattopadhyay, D. n/a To be Published n/a n/a n/a
2FM3 Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrates and cofactors Senkovich, O.A., Chattopadhyay, D. n/a To be Published n/a n/a n/a
2FN7 Structure of cryptosporidium parvum lactate dehydrogenase in complex with substrates and cofactors Senkovich, O.A., Chattopadhyay, D. n/a To be Published n/a n/a n/a
2FNZ Structure of cryptosporidium parvum lactate dehydrogenase in complex with substrates and cofactors Senkovich, O.A., Chattopadhyay, D. n/a To be Published n/a n/a n/a
2FRM Structure of cryptosporidium parvum lactate dehydrogenase in complex with substrates and cofactors Senkovich, O.A., Chattopadyay, D. n/a To be Published n/a n/a n/a
2G8Y The structure of a putative malate/lactate dehydrogenase from E. coli. Cuff, M.E., Skarina, T., Edwards, A., Savchenko, A., Cymborowski, M., Minor, W., Joachimiak, A. n/a To be Published n/a n/a n/a
2HJR Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Vedadi, M., Lew, J., Artz, J., Amani, M., Zhao, Y., Dong, A., Wasney, G.A., Gao, M., Hills, T., Brokx, S., Qiu, W., Sharma, S., Diassiti, A., Alam, Z., Melone, M., Mulichak, A., Wernimont, A., Bray, J., Loppnau, P., Plotnikova, O., Newberry, K., Sundararajan, E., Houston, S., Walker, J., Tempel, W., Bochkarev, A., Kozieradzki, I., Edwards, A., Arrowsmith, C., Roos, D., Kain, K., Hui, R. 2007 Mol.Biochem.Parasitol. 151 100 17125854
2I6T Structural Investigation into the L-lactate Dehydrogenase Domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A Avvakumov, G.V., Walker, J.R., Xue, S., Newman, E.M., Finerty Jr., P.J., Butler-Cole, C., Tempel, W., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S. n/a To be Published n/a n/a n/a
2LDB Structure determination and refinement of Bacillus stearothermophilus lactate dehydrogenase. Piontek, K., Chakrabarti, P., Schar, H.P., Rossmann, M.G., Zuber, H. 1990 Proteins 7 74 2330370
2LDX Characterization of the antigenic sites on the refined 3-A resolution structure of mouse testicular lactate dehydrogenase C4. Hogrefe, H.H., Griffith, J.P., Rossmann, M.G., Goldberg, E. 1987 J.Biol.Chem. 262 13155 2443489
2OZ0 Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base. Tsai, C.L., Gokulan, K., Sobrado, P., Sacchettini, J.C., Fitzpatrick, P.F. 2007 Biochemistry 46 7844 17563122
2PI1 Crystal structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD and lactic acid. Antonyuk, S.V., Ellis, M.J., Strange, R.W., Hasnain, S.S., Bessho, Y., Kuramitsu, S., Yokoyama, S. n/a To be Published n/a n/a n/a
2V65 Activity, Stability and Structural Studies of Lactate Dehydrogenases Adapted to Extreme Thermal Environments. Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F., Madern, D. 2007 J.Mol.Biol. 374 547 17936781
2V6B Activity, Stability and Structural Studies of Lactate Dehydrogenases Adapted to Extreme Thermal Environments. Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F., Madern, D. 2007 J.Mol.Biol. 374 547 17936781
2V6M Activity, Stability and Structural Studies of Lactate Dehydrogenases Adapted to Extreme Thermal Environments. Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F., Madern, D. 2007 J.Mol.Biol. 374 547 17936781
2V7P Activity, Stability and Structural Studies of Lactate Dehydrogenases Adapted to Extreme Thermal Environments. Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F., Madern, D. 2007 J.Mol.Biol. 374 547 17936781
3LDH A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes. White, J.L., Hackert, M.L., Buehner, M., Adams, M.J., Ford, G.C., Lentz Jr., P.J., Smiley, I.E., Steindel, S.J., Rossmann, M.G. 1976 J.Mol.Biol. 102 759 940154
4GPD Structure of lobster apo-D-glyceraldehyde-3-phosphate dehydrogenase at 3.0 A resolution. Murthy, M.R., Garavito, R.M., Johnson, J.E., Rossmann, M.G. 1980 J.Mol.Biol. 138 859 7411626
4MDH Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution. Birktoft, J.J., Rhodes, G., Banaszak, L.J. 1989 Biochemistry 28 6065 2775751
5LDH Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7 A resolution. Grau, U.M., Trommer, W.E., Rossmann, M.G. 1981 J.Mol.Biol. 151 289 7338899
5MDH Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD. Chapman, A.D., Cortes, A., Dafforn, T.R., Clarke, A.R., Brady, R.L. 1999 J.Mol.Biol. 285 703 10075524
6LDH Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. Abad-Zapatero, C., Griffith, J.P., Sussman, J.L., Rossmann, M.G. 1987 J.Mol.Biol. 198 445 3430615
8LDH Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. Abad-Zapatero, C., Griffith, J.P., Sussman, J.L., Rossmann, M.G. 1987 J.Mol.Biol. 198 445 3430615
9LDB Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Dunn, C.R., Wilks, H.M., Halsall, D.J., Atkinson, T., Clarke, A.R., Muirhead, H., Holbrook, J.J. 1991 Philos.Trans.R.Soc.London, Ser.B 332 177 1678537
9LDT Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Dunn, C.R., Wilks, H.M., Halsall, D.J., Atkinson, T., Clarke, A.R., Muirhead, H., Holbrook, J.J. 1991 Philos.Trans.R.Soc.London, Ser.B 332 177 1678537

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