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Transposase
A Tetrameric Transposase
Transposases use many different mechanisms for cutting and pasting DNA. This one, the lambda integrase from a bacteriophage (PDB entry 1z1g), uses a more complex mechanism than the Tn5 transposase. This structure again catches the enzyme in the middle of its reaction, which involves an elaborate looping of DNA in and around the enzyme. In the process, an X-shaped Holliday junction is formed inside the enzyme, as shown in the lower illustration.
Last changed by: A.Honegger,