Virtuelle (Nano) Welten PDB Molecule of the Month 81: Cytochrome p450

Structure ID	Title	Authors	Publication Year	Journal Name	Volume ID	First Page	Pubmed
1AKD	Crystal structure of cytochrome P-450cam complexed with the (1S)-camphor enantiomer.	Schlichting, I., Jung, C., Schulze, H.	1997	FEBS Lett.	415	253	9357977
1AMO	Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.	Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., Masters, B.S., Kim, J.J.	1997	Proc.Natl.Acad.Sci.USA	94	8411	9237990
1B1C	Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.	Zhao, Q., Modi, S., Smith, G., Paine, M., McDonagh, P.D., Wolf, C.R., Tew, D., Lian, L.Y., Roberts, G.C., Driessen, H.P.	1999	Protein Sci.	8	298	10048323
1BU7	Structure of a cytochrome P450-redox partner electron-transfer complex.	Sevrioukova, I.F., Li, H., Zhang, H., Peterson, J.A., Poulos, T.L.	1999	Proc.Natl.Acad.Sci.USA	96	1863	10051560
1BVY	Structure of a cytochrome P450-redox partner electron-transfer complex.	Sevrioukova, I.F., Li, H., Zhang, H., Peterson, J.A., Poulos, T.L.	1999	Proc.Natl.Acad.Sci.USA	96	1863	10051560
1CL6	Proton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes.	Shimizu, H., Obayashi, E., Gomi, Y., Arakawa, H., Park, S.Y., Nakamura, H., Adachi, S., Shoun, H., Shiro, Y.	2000	J.Biol.Chem.	275	4816	10671516
1CMJ	Proton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes.	Shimizu, H., Obayashi, E., Gomi, Y., Arakawa, H., Park, S.Y., Nakamura, H., Adachi, S., Shoun, H., Shiro, Y.	2000	J.Biol.Chem.	275	4816	10671516
1CMN	Proton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes.	Shimizu, H., Obayashi, E., Gomi, Y., Arakawa, H., Park, S.Y., Nakamura, H., Adachi, S., Shoun, H., Shiro, Y.	2000	J.Biol.Chem.	275	4816	10671516
1CP4	Formation, crystal structure, and rearrangement of a cytochrome P-450cam iron-phenyl complex.	Raag, R., Swanson, B.A., Poulos, T.L., Ortiz de Montellano, P.R.	1990	Biochemistry	29	8119	2261467
1CPO	The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid.	Sundaramoorthy, M., Terner, J., Poulos, T.L.	1995	Structure	3	1367	8747463
1CPT	Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution.	Hasemann, C.A., Ravichandran, K.G., Peterson, J.A., Deisenhofer, J.	1994	J.Mol.Biol.	236	1169	8120894
1DDG	Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.	Gruez, A., Pignol, D., Zeghouf, M., Coves, J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps, J.C.	2000	J.Mol.Biol.	299	199	10860732
1DDI	Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.	Gruez, A., Pignol, D., Zeghouf, M., Coves, J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps, J.C.	2000	J.Mol.Biol.	299	199	10860732
1DT6	Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity.	Williams, P.A., Cosme, J., Sridhar, V., Johnson, E.F., McRee, D.E.	2000	Mol.Cell	5	121	10678174
1DZ4	The catalytic pathway of cytochrome p450cam at atomic resolution.	Schlichting, I., Berendzen, J., Chu, K., Stock, A.M., Maves, S.A., Benson, D.E., Sweet, R.M., Ringe, D., Petsko, G.A., Sligar, S.G.	2000	Science	287	1615	10698731
1DZ6	The catalytic pathway of cytochrome p450cam at atomic resolution.	Schlichting, I., Berendzen, J., Chu, K., Stock, A.M., Maves, S.A., Benson, D.E., Sweet, R.M., Ringe, D., Petsko, G.A., Sligar, S.G.	2000	Science	287	1615	10698731
1DZ8	The catalytic pathway of cytochrome p450cam at atomic resolution.	Schlichting, I., Berendzen, J., Chu, K., Stock, A.M., Maves, S.A., Benson, D.E., Sweet, R.M., Ringe, D., Petsko, G.A., Sligar, S.G.	2000	Science	287	1615	10698731
1DZ9	The catalytic pathway of cytochrome p450cam at atomic resolution.	Schlichting, I., Berendzen, J., Chu, K., Stock, A.M., Maves, S.A., Benson, D.E., Sweet, R.M., Ringe, D., Petsko, G.A., Sligar, S.G.	2000	Science	287	1615	10698731
1E6E	Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis.	Muller, J.J., Lapko, A., Bourenkov, G., Ruckpaul, K., Heinemann, U.	2001	J.Biol.Chem.	276	2786	11053423
1E9X	Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors	Podust, L.M., Poulos, T.L., Waterman, M.R.	2001	Proc.Natl.Acad.Sci.USA	98	3068	11248033
1EA1	Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors	Podust, L.M., Poulos, T.L., Waterman, M.R.	2001	Proc.Natl.Acad.Sci.USA	98	3068	11248033
1EGY	Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity.	Cupp-Vickery, J., Anderson, R., Hatziris, Z.	2000	Proc.Natl.Acad.Sci.USA	97	3050	10716705
1EHE	Crystal structures of cytochrome P450nor and its mutants (Ser286-->Val, Thr) in the ferric resting state at cryogenic temperature: a comparative analysis with monooxygenase cytochrome P450s.	Shimizu, H., Park, S., Lee, D., Shoun, H., Shiro, Y.	2000	J.Inorg.Biochem.	81	191	11051564
1EHF	Crystal structures of cytochrome P450nor and its mutants (Ser286-->Val, Thr) in the ferric resting state at cryogenic temperature: a comparative analysis with monooxygenase cytochrome P450s.	Shimizu, H., Park, S., Lee, D., Shoun, H., Shiro, Y.	2000	J.Inorg.Biochem.	81	191	11051564
1EHG	Crystal structures of cytochrome P450nor and its mutants (Ser286-->Val, Thr) in the ferric resting state at cryogenic temperature: a comparative analysis with monooxygenase cytochrome P450s.	Shimizu, H., Park, S., Lee, D., Shoun, H., Shiro, Y.	2000	J.Inorg.Biochem.	81	191	11051564
1EUP	Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity.	Cupp-Vickery, J., Anderson, R., Hatziris, Z.	2000	Proc.Natl.Acad.Sci.USA	97	3050	10716705
1F20	Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase.	Zhang, J., Martasek, P., Paschke, R., Shea, T., Siler Masters, B.S., Kim, J.J.	2001	J.Biol.Chem.	276	37506	11473123
1F24	Mutation Effects of Conserved Threonine(Thr243) of Cytochrome P450nor on Its Structure and Function	Shimizu, H., PARK, S.-Y.	n/a	To be Published	n/a	n/a	n/a
1F25	Mutation Effects of Conserved Threonine(Thr243) of Cytochrome P450nor on Its Structure and Function	Shimizu, H., PARK, S.-Y.	n/a	To be Published	n/a	n/a	n/a
1F26	Mutation Effects of Conserved Threonine(Thr243) of Cytochrome P450nor on Its Structure and Function	Shimizu, H., PARK, S.-Y.	n/a	To be Published	n/a	n/a	n/a
1F4T	Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus.	Yano, J.K., Koo, L.S., Schuller, D.J., Li, H., Ortiz de Montellano, P.R., Poulos, T.L.	2000	J.Biol.Chem.	275	31086	10859321
1F4U	Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus.	Yano, J.K., Koo, L.S., Schuller, D.J., Li, H., Ortiz de Montellano, P.R., Poulos, T.L.	2000	J.Biol.Chem.	275	31086	10859321
1FAG	The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid.	Li, H., Poulos, T.L.	1997	Nat.Struct.Biol.	4	140	9033595
1FAH	The role of Thr268 in oxygen activation of cytochrome P450BM-3.	Yeom, H., Sligar, S.G., Li, H., Poulos, T.L., Fulco, A.J.	1995	Biochemistry	34	14733	7578081
1GED	A positively charged cluster formed in the heme-distal pocket of cytochrome P450nor is essential for interaction with NADH	Kudo, T., Takaya, N., Park, S.-Y., Shiro, Y., Shoun, H.	2001	J.Biol.Chem.	276	5020	11076941
1GEI	Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam.	Lee, D.S., Park, S.Y., Yamane, K., Obayashi, E., Hori, H., Shiro, Y.	2001	Biochemistry	40	2669	11258878
1GEJ	Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam.	Lee, D.S., Park, S.Y., Yamane, K., Obayashi, E., Hori, H., Shiro, Y.	2001	Biochemistry	40	2669	11258878
1GEK	Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam.	Lee, D.S., Park, S.Y., Yamane, K., Obayashi, E., Hori, H., Shiro, Y.	2001	Biochemistry	40	2669	11258878
1GEM	Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam.	Lee, D.S., Park, S.Y., Yamane, K., Obayashi, E., Hori, H., Shiro, Y.	2001	Biochemistry	40	2669	11258878
1GJM	Covalent Attachment of an Electroactive Sulphydryl Reagent in the Active Site of Cytochrome P450Cam as Revealed by the Crystal Structure of the Modified Protein	Digleria, K., Nickerson, D.P., Hill, H.A.O., Wong, L.-L., Fulop, V.	1998	J.Am.Chem.Soc.	120	46	n/a
1GWI	The 1.92 A Structure of Streptomyces Coelicolor A3(2) Cyp154C1: A New Monooxygenase that Functionalizes Macrolide Ring Systems	Podust, L., Kim, Y., Arase, M., Neely, B., Beck, B., Bach, H., Sherman, D., Lamb, D., Kelly, S., Waterman, M.	2003	J.Biol.Chem.	278	12214	n/a
1H5Z	Estriol Bound and Ligand-Free Structures of Sterol 14Alpha-Demethylase	Podust, L.M., Yermalitskaya, L.V., Lepesheva, G.I., Dalmasso, V.N.Podu E.A., Waterman, M.R.	2004	Structure	12	1937	n/a
1IO7	Crystallization and preliminary X-ray diffraction analysis of a cytochrome P450 (CYP119) from Sulfolobus solfataricus.	Park, S.Y., Yamane, K., Adachi, S., Shiro, Y., Weiss, K.E., Sligar, S.G.	2000	Acta Crystallogr., Sect.D	56	1173	10957637
1IO8	Crystallization and preliminary X-ray diffraction analysis of a cytochrome P450 (CYP119) from Sulfolobus solfataricus.	Park, S.Y., Yamane, K., Adachi, S., Shiro, Y., Weiss, K.E., Sligar, S.G.	2000	Acta Crystallogr., Sect.D	56	1173	10957637
1IO9	Crystallization and preliminary X-ray diffraction analysis of a cytochrome P450 (CYP119) from Sulfolobus solfataricus.	Park, S.Y., Yamane, K., Adachi, S., Shiro, Y., Weiss, K.E., Sligar, S.G.	2000	Acta Crystallogr., Sect.D	56	1173	10957637
1IZO	Substrate Recognition and Molecular Mechanism of Fatty Acid Hydroxylation by Cytochrome P450 from Bacillus subtilis. CRYSTALLOGRAPHIC, SPECTROSCOPIC, AND MUTATIONAL STUDIES.	Lee, D.S., Yamada, A., Sugimoto, H., Matsunaga, I., Ogura, H., Ichihara, K., Adachi, S., Park, S.Y., Shiro, Y.	2003	J.Biol.Chem.	278	9761	12519760
1J9Z	NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.	Hubbard, P.A., Shen, A.L., Paschke, R., Kasper, C.B., Kim, J.J.	2001	J.Biol.Chem.	276	29163	11371558
1JA0	NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.	Hubbard, P.A., Shen, A.L., Paschke, R., Kasper, C.B., Kim, J.J.	2001	J.Biol.Chem.	276	29163	11371558
1JA1	NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.	Hubbard, P.A., Shen, A.L., Paschke, R., Kasper, C.B., Kim, J.J.	2001	J.Biol.Chem.	276	29163	11371558
1JFB	X-ray structure of nitric oxide reductase (cytochrome P450nor) at atomic resolution	Shimizu, H., Park, S.Y., Shiro, Y., Adachi, S.	2002	Acta Crystallogr., Sect.D	58	81	11752781
1JFC	X-ray structure of nitric oxide reductase (cytochrome P450nor) at atomic resolution	Shimizu, H., Park, S.Y., Shiro, Y., Adachi, S.	2002	Acta Crystallogr., Sect.D	58	81	11752781
1JIN	Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.	Cupp-Vickery, J.R., Garcia, C., Hofacre, A., McGee-Estrada, K.	2001	J.Mol.Biol.	311	101	11469860
1JIO	Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.	Cupp-Vickery, J.R., Garcia, C., Hofacre, A., McGee-Estrada, K.	2001	J.Mol.Biol.	311	101	11469860
1JIP	Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.	Cupp-Vickery, J.R., Garcia, C., Hofacre, A., McGee-Estrada, K.	2001	J.Mol.Biol.	311	101	11469860
1JME	Structural and spectroscopic analysis of the F393H mutant of flavocytochrome P450 BM3.	Ost, T.W., Munro, A.W., Mowat, C.G., Taylor, P.R., Pesseguiero, A., Fulco, A.J., Cho, A.K., Cheesman, M.A., Walkinshaw, M.D., Chapman, S.K.	2001	Biochemistry	40	13430	11695889
1JPZ	Pivotal role of water in the mechanism of P450BM-3.	Haines, D.C., Tomchick, D.R., Machius, M., Peterson, J.A.	2001	Biochemistry	40	13456	11695892
1K2O	Probing the open state of cytochrome P450cam with ruthenium-linker substrates.	Dunn, A.R., Dmochowski, I.J., Bilwes, A.M., Gray, H.B., Crane, B.R.	2001	Proc.Natl.Acad.Sci.USA	98	12420	11606730
1LFK	Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis.	Zerbe, K., Pylypenko, O., Vitali, F., Zhang, W., Rouset, S., Heck, M., Vrijbloed, J.W., Bischoff, D., Bister, B., Sussmuth, R.D., Pelzer, S., Wohlleben, W., Robinson, J.A., Schlichting, I.	2002	J.Biol.Chem.	277	47476	12207020
1LG9	Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis.	Zerbe, K., Pylypenko, O., Vitali, F., Zhang, W., Rouset, S., Heck, M., Vrijbloed, J.W., Bischoff, D., Bister, B., Sussmuth, R.D., Pelzer, S., Wohlleben, W., Robinson, J.A., Schlichting, I.	2002	J.Biol.Chem.	277	47476	12207020
1LGF	Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis.	Zerbe, K., Pylypenko, O., Vitali, F., Zhang, W., Rouset, S., Heck, M., Vrijbloed, J.W., Bischoff, D., Bister, B., Sussmuth, R.D., Pelzer, S., Wohlleben, W., Robinson, J.A., Schlichting, I.	2002	J.Biol.Chem.	277	47476	12207020
1LWL	Fluorescent probes for cytochrome P450 structural characterization and inhibitor screening	Dunn, A.R., Hays, A.M., Goodin, D.B., Stout, C.D., Chiu, R., Winkler, J.R., Gray, H.B.	2002	J.AM.CHEM.SOC.	124	10254	12197708
1N40	Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450.	Leys, D., Mowat, C.G., McLean, K.J., Richmond, A., Chapman, S.K., Walkinshaw, M.D., Munro, A.W.	2003	J.Biol.Chem.	278	5141	12435731
1N4G	Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450.	Leys, D., Mowat, C.G., McLean, K.J., Richmond, A., Chapman, S.K., Walkinshaw, M.D., Munro, A.W.	2003	J.Biol.Chem.	278	5141	12435731
1N6B	Structure of a Substrate Complex of Mammalian Cytochrome P450 2C5 at 2.3 A Resolution: Evidence for Multiple Substrate Binding Modes	Wester, M.R., Johnson, E.F., Marques-Soares, C., Dansette, P.M., Mansuy, D., Stout, C.D.	2003	Biochemistry	42	6370	12767218
1N97	Preliminary Characterization and Crystal Structure of a Thermostable Cytochrome P450 from Thermus thermophilus	Yano, J.K., Blasco, F., Li, H., Schmid, R.D., Henne, A., Poulos, T.L.	2003	J.Biol.Chem.	278	608	12401810
1NR6	Structure of Mammalian Cytochrome P450 2C5 Complexed with Diclofenac at 2.1 A Resolution: Evidence for an Induced Fit Model of Substrate Binding	WESTER, M.R., JOHNSON, E.F., Marques-Soares, C., Dijols, S., Dansette, P.M., Mansuy, D., STOUT, C.D.	2003	Biochemistry	42	9335	12899620
1O76	Crystal Structures of Cyanide Complexes of P450Cam and the Oxygenase Domain of Inducible Nitric Oxide Synthase-Structural Models of the Short-Lived Oxygen Complexes	Fedorov, R., Ghosh, D., Schlichting, I.	2003	Arch.Biochem.Biophys.	409	25	n/a
1ODO	Comparison of the 1.85 A Structure of Cyp154A1 from Streptomyces Coelicolor A3(2) with the Closely Related Cyp154C1 and Cyps from Antibiotic Biosynthetic Pathways	Podust, L.M., Bach, H., Kim, Y., Lamb, D.C., Arase, M., Kelly, D.H.Sherma S.L., Waterman, M.R.	2004	Protein Sci.	13	255	n/a
1OG2	Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin	Williams, P.A., Cosme, J., Ward, A., Angove, H.C., Matak Vinkovic, D., Jhoti, H.	2003	Nature	424	464	n/a
1OG5	Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin	Williams, P.A., Cosme, J., Ward, A., Angove, H.C., Matak Vinkovic, D., Jhoti, H.	2003	Nature	424	464	n/a
1OXA	Structure of cytochrome P450eryF involved in erythromycin biosynthesis.	Cupp-Vickery, J.R., Poulos, T.L.	1995	Nat.Struct.Biol.	2	144	7749919
1P0V	Oxygen Activation and Electron Transfer in Flavocytochrome P450 BM3	Ost, T.W.B., Clark, J., Mowat, C.G., Miles, C.S., Walkinshaw, M.D., Reid, G.A., Chapman, S.K., Daff, S.	2003	J.Am.Chem.Soc.	125	15010	14653735
1P0W	Oxygen Activation and Electron Transfer in Flavocytochrome P450 BM3	Ost, T.W.B., Clark, J., Mowat, C.G., Miles, C.S., Walkinshaw, M.D., Reid, G.A., Chapman, S.K., Daff, S.	2003	J.Am.Chem.Soc.	125	15010	14653735
1P0X	Oxygen Activation and Electron Transfer in Flavocytochrome P450 BM3	Ost, T.W.B., Clark, J., Mowat, C.G., Miles, C.S., Walkinshaw, M.D., Reid, G.A., Chapman, S.K., Daff, S.	2003	J.Am.Chem.Soc.	125	15010	14653735
1PHA	Inhibitor-induced conformational change in cytochrome P-450CAM.	Raag, R., Li, H., Jones, B.C., Poulos, T.L.	1993	Biochemistry	32	4571	8485133
1PHB	Inhibitor-induced conformational change in cytochrome P-450CAM.	Raag, R., Li, H., Jones, B.C., Poulos, T.L.	1993	Biochemistry	32	4571	8485133
1PHC	Crystal structure of substrate-free Pseudomonas putida cytochrome P-450.	Poulos, T.L., Finzel, B.C., Howard, A.J.	1986	Biochemistry	25	5314	3768350
1PHD	Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam.	Poulos, T.L., Howard, A.J.	1987	Biochemistry	26	8165	3442650
1PHE	Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam.	Poulos, T.L., Howard, A.J.	1987	Biochemistry	26	8165	3442650
1PHF	Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam.	Poulos, T.L., Howard, A.J.	1987	Biochemistry	26	8165	3442650
1PHG	Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam.	Poulos, T.L., Howard, A.J.	1987	Biochemistry	26	8165	3442650
1PO5	An open conformation of mammalian cytochrome P450 2B4 at 1.6 A resolution	Scott, E.E., He, Y.A., Wester, M.R., White, M.A., Chin, C.C., Halpert, J.R., Johnson, E.F., Stout, C.D.	2003	Proc.Natl.Acad.Sci.USA	100	13196	14563924
1PQ2	Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site	Schoch, G.A., Yano, J.K., Wester, M.R., Griffin, K.J., Stout, C.D., Johnson, E.F.	2004	J.Biol.Chem.	279	9497	14676196
1Q5D	Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK	Nagano, S., Li, H., Shimizu, H., Nishida, C., Ogura, H., Ortiz de Montellano, P.R., Poulos, T.L.	2003	J.Biol.Chem.	278	44886	12933799
1Q5E	Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK	Nagano, S., Li, H., Shimizu, H., Nishida, C., Ogura, H., Ortiz de Montellano, P.R., Poulos, T.L.	2003	J.Biol.Chem.	278	44886	12933799
1QMQ	Optical detection of cytochrome P450 by sensitizer-linked substrates.	Dmochowski, I.J., Crane, B.R., Wilker, J.J., Winkler, J.R., Gray, H.B.	1999	Proc.Natl.Acad.Sci.USA	96	12987	10557259
1R9O	The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0 A Resolution	Wester, M.R., Yano, J.K., Schoch, G.A., Yang, C., Griffin, K.J., Stout, C.D., Johnson, E.F.	2004	J.Biol.Chem.	279	35630	15181000
1ROM	Crystal structure of nitric oxide reductase from denitrifying fungus Fusarium oxysporum.	Park, S.Y., Shimizu, H., Adachi, S., Nakagawa, A., Tanaka, I., Nakahara, K., Shoun, H., Obayashi, E., Nakamura, H., Iizuka, T., Shiro, Y.	1997	Nat.Struct.Biol.	4	827	9334748
1S1F	Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2	Zhao, B., Guengerich, F.P., Bellamine, A., Lamb, D.C., Izumikawa, M., Lei, L., Podust, L.M., Sundaramoorthy, M., Kalaitzis, J.A., Reddy, L.M., Kelly, S.L., Moore, B.S., Stec, D., Voehler, M., Falck, J.R., Shimada, T., Waterman, M.R.	2005	J.Biol.Chem.	280	11599	15659395
1SE6	Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2.	Zhao, B., Guengerich, F.P., Bellamine, A., Lamb, D.C., Izumikawa, M., Lei, L., Podust, L.M., Sundaramoorthy, M., Kalaitzis, J.A., Reddy, L.M., Kelly, S.L., Moore, B.S., Stec, D., Voehler, M., Falck, J.R., Shimada, T., Waterman, M.R.	2005	J.Biol.Chem.	280	11599	15659395
1SMI	A Single Mutation in Cytochrome P450 BM3 Induces the Conformational Rearrangement Seen upon Substrate Binding in the Wild-type Enzyme	Joyce, M.G., Girvan, H.M., Munro, A.W., Leys, D.	2004	J.Biol.Chem.	279	23287	15020590
1SMJ	A Single Mutation in Cytochrome P450 BM3 Induces the Conformational Rearrangement Seen upon Substrate Binding in the Wild-type Enzyme	Joyce, M.G., Girvan, H.M., Munro, A.W., Leys, D.	2004	J.Biol.Chem.	279	23287	15020590
1SUO	Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9 {angstrom} resolution: Insight into the range of P450 conformations and coordination of redox partner binding.	Scott, E.E., White, M.A., He, Y.A., Johnson, E.F., Stout, C.D., Halpert, J.R.	2004	J.Biol.Chem.	279	27294	15100217
1T85	Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding	Nagano, S., Tosha, T., Ishimori, K., Morishima, I., Poulos, T.L.	2004	J.Biol.Chem.	279	42844	15269210
1T86	Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding	Nagano, S., Tosha, T., Ishimori, K., Morishima, I., Poulos, T.L.	2004	J.Biol.Chem.	279	42844	15269210
1T87	Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding	Nagano, S., Tosha, T., Ishimori, K., Morishima, I., Poulos, T.L.	2004	J.Biol.Chem.	279	42844	15269210
1T88	Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding	Nagano, S., Tosha, T., Ishimori, K., Morishima, I., Poulos, T.L.	2004	J.Biol.Chem.	279	42844	15269210
1T93	Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2.	Zhao, B., Guengerich, F.P., Bellamine, A., Lamb, D.C., Izumikawa, M., Lei, L., Podust, L.M., Sundaramoorthy, M., Kalaitzis, J.A., Reddy, L.M., Kelly, S.L., Moore, B.S., Stec, D., Voehler, M., Falck, J.R., Shimada, T., Waterman, M.R.	2005	J.Biol.Chem.	280	11599	15659395
1TQN	The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-A Resolution	Yano, J.K., Wester, M.R., Schoch, G.A., Griffin, K.J., Stout, C.D., Johnson, E.F.	2004	J.Biol.Chem.	279	38091	15258162
1U13	Crystal structure analysis of the C37L/C151T/C442A-triple mutant of CYP51 from Mycobacterium tuberculosis	Podust, L.M., Yermalitskaya, L.V., Kim, Y., Waterman, M.R.	n/a	To be published	n/a	n/a	n/a
1UE8	Structure and direct electrochemistry of cytochrome P450 from the thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain 7	Oku, Y., Ohtaki, A., Kamitori, S., Nakamura, N., Yohda, M., Ohno, H., Kawarabayasi, Y.	2004	J.Inorg.Biochem.	98	1194	15219985
1UED	Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis	Pylypenko, O., Vitali, F., Zerbe, K., Robinson, J.A., Schlichting, I.	2003	J.Biol.Chem.	278	46727	12888556
1ULW	Structural evidence for direct hydride transfer from NADH to cytochrome P450nor	Oshima, R., Fushinobu, S., Su, F., Zhang, L., Takaya, N., Shoun, H.	2004	J.Mol.Biol.	342	207	15313618
1UYU	A Survey of Active Site Access Channels in Cytochromes P450	Wade, R.C., Winn, P.J., Schlichting, I., Sudarko	2004	J.Inorg.Biochem.	98	1175	n/a
1W0E	Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone	Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.	2004	Science	305	683	n/a
1W0F	Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone	Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.	2004	Science	305	683	n/a
1W0G	Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone	Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.	2004	Science	305	683	n/a
1WIY	Crystal Structure Analysis of Cytochrome P450 from Thermus thermophilus HB8	Kousumi, Y., Nakagawa, N., Kaneko, M., Yamamoto, H., Masui, R., Kuramitsu, S., Ueyama, N.	n/a	To be Published	n/a	n/a	n/a
1X8V	Estriol Bound and Ligand-free Structures of Sterol 14alpha-Demethylase.	Podust, L.M., Yermalitskaya, L.V., Lepesheva, G.I., Podust, V.N., Dalmasso, E.A., Waterman, M.R.	2004	Structure	12	1937	15530358
1XQD	Structural evidence for direct hydride transfer from NADH to cytochrome P450nor	Oshima, R., Fushinobu, S., Su, F., Zhang, L., Takaya, N., Shoun, H.	2004	J.Mol.Biol.	342	207	15313618
1YQO	The role of Thr268 and Phe393 in cytochrome P450 BM3.	Clark, J.P., Miles, C.S., Mowat, C.G., Walkinshaw, M.D., Reid, G.A., Daff, S.N., Chapman, S.K.	2006	J.Inorg.Biochem.	100	1075	16403573
1YQP	The role of Thr268 and Phe393 in cytochrome P450 BM3.	Clark, J.P., Miles, C.S., Mowat, C.G., Walkinshaw, M.D., Reid, G.A., Daff, S.N., Chapman, S.K.	2006	J.Inorg.Biochem.	100	1075	16403573
1Z10	Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen	Yano, J.K., Hsu, M.H., Griffin, K.J., Stout, C.D., Johnson, E.F.	2005	Nat.Struct.Mol.Biol.	12	822	16086027
1Z11	Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen	Yano, J.K., Hsu, M.H., Griffin, K.J., Stout, C.D., Johnson, E.F.	2005	Nat.Struct.Mol.Biol.	12	822	16086027
1Z8O	Crystal Structures of the Ferrous Dioxygen Complex of Wild-Type Cytochrome P450Eryf and its Mutants, A245S and A245T: Investigation of the Proton Transfer System in P450Eryf	Nagano, S., Cupp-Vickery, J.R., Poulos, T.L.	2005	J.Biol.Chem.	280	22102	15824115
1Z8P	Crystal Structures of the Ferrous Dioxygen Complex of Wild-Type Cytochrome P450Eryf and its Mutants, A245S and A245T: Investigation of the Proton Transfer System in P450Eryf	Poulos, T.L., Nagano, S.	2005	J.Biol.Chem.	280	22102	15824115
1Z8Q	Crystal Structures of the Ferrous Dioxygen Complex of Wild-Type Cytochrome P450Eryf and its Mutants, A245S and A245T: Investigation of the Proton Transfer System in P450Eryf	Nagano, S., Cupp-Vickery, J.R., Poulos, T.L.	2005	J.Biol.Chem.	280	22102	15824115
1ZO4	Active Site Mutations of P450BM-3 that Dramatically Affect Substrate Binding and Product Formation	Hegda, A., Chen, B., Haines, D.C., Bondlela, M., Mullin, D., Graham, S.E., Tomchick, D.R., Machius, M., Peterson, J.A.	n/a	To be Published	n/a	n/a	n/a
1ZO9	Interactions of Substrates at the Surface of P450s: A Novel Design for P450 Inhibitors	Hegda, A., Chen, B., Tomchick, D.R., Bondlela, M., Haines, D.C., Schaffer, N., Machius, M., Graham, S.E., Peterson, J.A.	n/a	To be Published	n/a	n/a	n/a
1ZOA	Active Site Mutations of P450BM-3 that Dramatically Affect Substrate Binding and Product Formation	Hegda, A., Chen, B., Haines, D.C., Bondlela, M., Mullin, D., Graham, S.E., Tomchick, D.R., Machius, M., Peterson, J.A.	n/a	To be Published	n/a	n/a	n/a
2A1M	Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism	Nagano, S., Poulos, T.L.	2005	J.Biol.Chem.	280	31659	15994329
2A1N	Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism	Nagano, S., Poulos, T.L.	2005	J.Biol.Chem.	280	31659	15994329
2A1O	Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism	Nagano, S., Poulos, T.L.	2005	J.Biol.Chem.	280	31659	15994329
2BDM	Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.	Zhao, Y., White, M.A., Muralidhara, B.K., Sun, L., Halpert, J.R., Stout, C.D.	2006	J.Biol.Chem.	281	5973	16373351
2BF4	A Second Fmn-Binding Site in Yeast Nadph-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases.	Lamb, D.C., Kim, Y., Yermalitskaya, L.V., Yermalitsky, V.N., Lepesheva, G.I., Kelly, S.L., Waterman, M.R., Podust, L.M.	2006	Structure	14	51	n/a
2BMH	Modeling Protein-Substrate Interactions in the Heme Domain of Cytochrome P450Bm-3	Li, H., Poulos, T.L.	1995	Acta Crystallogr.,Sect.D	51	21	n/a
2BN4	A Second Fmn-Binding Site in Yeast Nadph-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases.	Lamb, D.C., Kim, Y., Yermalitskaya, L.V., Yermalitsky, V.N., Lepesheva, G.I., Kelly, S.L., Waterman, M.R., Podust, L.M.	2006	Structure	14	51	n/a
2BPO	Crystal Structure of the Yeast Cpr Triple Mutant: D74G, Y75F, K78A.	Yermalitskaya, L.V., Kim, Y., Waterman, M.R., Podust, L.M.	n/a	To be Published	n/a	n/a	n/a
2BT6	Light-Induced Reduction of Bovine Adrenodoxin Via the Covalently Bound Ruthenium(II) Bipyridyl Complex: Intramolecular Electron Transfer and Crystal Structure.	Halavaty, A., Mueller, J.J., Contzen, J., Jung, C., Hannemann, F., Bernhardt, R., Galander, M., Lendzian, F., Heinemann, U.	2006	Biochemistry	45	709	n/a
2BVJ	The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae.	Sherman, D.H., Li, S., Yermalitskaya, L.V., Kim, Y., Smith, J.A., Waterman, M.R., Podust, L.M.	2006	J.Biol.Chem.	281	26289	n/a
2C6H	The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae.	Sherman, D.H., Li, S., Yermalitskaya, L.V., Kim, Y., Smith, J.A., Waterman, M.R., Podust, L.M.	2006	J.Biol.Chem.	281	26289	n/a
2C7X	The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae.	Sherman, D.H., Li, S., Yermalitskaya, L.V., Kim, Y., Smith, J.A., Waterman, M.R., Podust, L.M.	2006	J.Biol.Chem.	281	26289	n/a
2CII	The Crystal Structure of H-2Db Complexed with a Partial Peptide Epitope Suggests a Major Histocompatibility Complex Class I Assembly Intermediate.	Glithero, A., Tormo, J., Doering, K., Kojima, M., Jones, E.Y., Elliott, T.	2006	J.Biol.Chem.	281	12699	n/a
2CP4	Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala.	Raag, R., Martinis, S.A., Sligar, S.G., Poulos, T.L.	1991	Biochemistry	30	11420	1742281
2CPO	The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid.	Sundaramoorthy, M., Terner, J., Poulos, T.L.	1995	Structure	3	1367	8747463
2CPP	High-resolution crystal structure of cytochrome P450cam.	Poulos, T.L., Finzel, B.C., Howard, A.J.	1987	J.Mol.Biol.	195	687	3656428
2D09	Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer	Zhao, B., Guengerich, F.P., Voehler, M., Waterman, M.R.	2005	J.Biol.Chem.	280	42188	16239228
2D0E	Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer	Zhao, B., Guengerich, F.P., Voehler, M., Waterman, M.R.	2005	J.Biol.Chem.	280	42188	16239228
2EVK	Structures of thiolate- and carboxylate-ligated ferric H93G myoglobin: models for cytochrome P450 and for oxyanion-bound heme proteins.	Qin, J., Perera, R., Lovelace, L.L., Dawson, J.H., Lebioda, L.	2006	Biochemistry	45	3170	16519512
2EVP	Structures of Thiolate- and Carboxylate-Ligated Ferric H93G Myoglobin: Models for Cytochrome P450 and for Oxyanion-Bound Heme Proteins(,).	Qin, J., Perera, R., Lovelace, L.L., Dawson, J.H., Lebioda, L.	2006	Biochemistry	45	3170	16519512
2F9Q	Crystal Structure of Human Cytochrome P450 2D6	Rowland, P., Blaney, F.E., Smyth, M.G., Jones, J.J., Leydon, V.R., Oxbrow, A.K., Lewis, C.J., Tennant, M.G., Modi, S., Eggleston, D.S., Chenery, R.J., Bridges, A.M.	2006	J.Biol.Chem.	281	7614	16352597
2FE6	The status of high-valent metal oxo complexes in the P450 cytochromes.	Makris, T.M., Koenig, K., Schlichting, I., Sligar, S.G.	2006	J.Inorg.Biochem.	100	507	16510191
2FER	The status of high-valent metal oxo complexes in the P450 cytochromes.	Makris, T.M., von Koenig, K., Schlichting, I., Sligar, S.G.	2006	J.Inorg.Biochem.	100	507	16510191
2FEU	The status of high-valent metal oxo complexes in the P450 cytochromes.	Makris, T.M., von Koenig, K., Schlichting, I., Sligar, S.G.	2006	J.Inorg.Biochem.	100	507	16510191
2H6P	Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is resultant of highly focused, peptide-dependent structural mimicry	Archbold, J.K., Macdonald, W.A., Miles, J.J., Brennan, R.M., Kjer-Nielsen, L., McCluskey, J., Burrows, S.R., Rossjohn, J.	n/a	To be Published	n/a	n/a	n/a
2HPD	Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's.	Ravichandran, K.G., Boddupalli, S.S., Hasermann, C.A., Peterson, J.A., Deisenhofer, J.	1993	Science	261	731	8342039
2J0C	Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4	Ekroos, M., Sjogren, T.	2006	Proc.Natl.Acad.Sci.USA	103	13682	n/a
2J0D	Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4	Ekroos, M., Sjogren, T.	2006	Proc.Natl.Acad.Sci.USA	103	13682	n/a
2ROM	Crystal structure of nitric oxide reductase from denitrifying fungus Fusarium oxysporum.	Park, S.Y., Shimizu, H., Adachi, S., Nakagawa, A., Tanaka, I., Nakahara, K., Shoun, H., Obayashi, E., Nakamura, H., Iizuka, T., Shiro, Y.	1997	Nat.Struct.Biol.	4	827	9334748
32C2	Structure of an activity suppressing Fab fragment to cytochrome P450 aromatase: insights into the antibody-antigen interactions.	Sawicki, M.W., Ng, P.C., Burkhart, B.M., Pletnev, V.Z., Higashiyama, T., Osawa, Y., Ghosh, D.	1999	Mol.Immunol.	36	423	10449095
3CP4	Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala.	Raag, R., Martinis, S.A., Sligar, S.G., Poulos, T.L.	1991	Biochemistry	30	11420	1742281
3CPP	Crystal structure of the carbon monoxide-substrate-cytochrome P-450CAM ternary complex.	Raag, R., Poulos, T.L.	1989	Biochemistry	28	7586	2611203
4CP4	Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala.	Raag, R., Martinis, S.A., Sligar, S.G., Poulos, T.L.	1991	Biochemistry	30	11420	1742281
4CPP	Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation.	Raag, R., Poulos, T.L.	1991	Biochemistry	30	2674	2001355
5CP4	Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect.	Vidakovic, M., Sligar, S.G., Li, H., Poulos, T.L.	1998	Biochemistry	37	9211	9649301
5CPP	The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM.	Raag, R., Poulos, T.L.	1989	Biochemistry	28	917	2713354
6CP4	Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect.	Vidakovic, M., Sligar, S.G., Li, H., Poulos, T.L.	1998	Biochemistry	37	9211	9649301
6CPP	Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation.	Raag, R., Poulos, T.L.	1991	Biochemistry	30	2674	2001355
7CPP	The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM.	Raag, R., Poulos, T.L.	1989	Biochemistry	28	917	2713354
8CPP	Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation.	Raag, R., Poulos, T.L.	1991	Biochemistry	30	2674	2001355