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Elongation Factors
It's Good to Recycle
Once EF-Tu has completed its job, the spent GDP must be pried out of its active site, so that a fresh GTP can bind. EF-Ts performs this task. It binds to the GDP form of EF-Tu and distorts it, destabilizing the binding of GDP and its accompanying magnesium ion. The structure shown here is from bacteria (PDB entry 1efu), with EF-Ts in green at the bottom and a molecule of EF-Tu in blue at the top.
Last changed by: A.Honegger,