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Amyloid-beta Precursor Protein

Exploring the Structure

Looking in the PDB, you can find structures of the amyloid-beta peptide in its two guises. The structure on the left (PDB entry 1iyt) shows the peptide as it might look when interacting with the membrane. Most of it is folded into an alpha helix, forming a more-or-less extended structure. The structure on the right (PDB entry 2beg) shows the form in the amyloid fibril. Thousands of the peptides stack on top of one another, each one interacting with its neighbors to form a long beta sheet.

This picture was created with RasMol. You can look at the structures by clicking on the accession codes here and picking one of the options under Display Options. Note that these structures were determined by NMR, so they have an ensemble of similar structures in the PDB file and many graphics programs will show a collection of overlapped structures.

A list of 'amyloid-beta precursor protein' related entries in the PDB as determined by a keyword search on June 30, 2006 is available. For additional reading, click here.

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