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Topoisomerase
Class II Topoisomerase
Class II topoisomerase performs the amazing feat of breaking a DNA double helix, passing another helix through the gap, and resealing the double helix behind it. The picture shown here is built from two PDB entries: 1bgw has the lower part of the topoisomerase, and 1ei1 is a domain from a gyrase, which is similar to the upper part of the topoisomerase. The topoisomerase is thought to be a highly dynamic structure, with several gates for entry of DNA into the two DNA-sized holes. Two tyrosine amino acids, shown in red, cleave the DNA strands and form a covalent bond with them, holding them tightly until the DNA can be restored.Next: Exploring the Structure
Previous: Topoisomerases
Last changed by: A.Honegger,