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Cholera Toxin
| PDB ID | Authors | First Page | PubMed ID | Journal Name | Citation Title | Volume No | Publication Year |
| 1S5E | C.J.O'Neal, E.I.Amaya, M.G.Jobling, R.K.Holmes, W.G.Hol | 3772 | 15049684 | Biochemistry | Crystal Structures of an Intrinsically Active Cholera Toxin Mutant Yield Insight Into the Toxin Activation Mechanism | 43 | 2004 |
| 1S5F | C.J.O'Neal, E.I.Amaya, M.G.Jobling, R.K.Holmes, W.G.Hol | 3772 | 15049684 | Biochemistry | Crystal Structures of an Intrinsically Active Cholera Toxin Mutant Yield Insight Into the Toxin Activation Mechanism | 43 | 2004 |
| 1S5B | C.J.O'Neal, E.I.Amaya, M.G.Jobling, R.K.Holmes, W.G.Hol | 3772 | 15049684 | Biochemistry | Crystal Structures of an Intrinsically Active Cholera Toxin Mutant Yield Insight Into the Toxin Activation Mechanism | 43 | 2004 |
| 1S5C | C.J.O'Neal, E.I.Amaya, M.G.Jobling, R.K.Holmes, W.G.Hol | 3772 | 15049684 | Biochemistry | Crystal Structures of an Intrinsically Active Cholera Toxin Mutant Yield Insight Into the Toxin Activation Mechanism | 43 | 2004 |
| 1S5D | C.J.O'Neal, E.I.Amaya, M.G.Jobling, R.K.Holmes, W.G.Hol | 3772 | 15049684 | Biochemistry | Crystal Structures of an Intrinsically Active Cholera Toxin Mutant Yield Insight Into the Toxin Activation Mechanism | 43 | 2004 |
| 1XTC | R.G.Zhang, D.L.Scott, M.L.Westbrook, S.Nance, B.D.Spangler, G.G.Shipley, E.M.Westbrook | 563 | 7658473 | J Mol Biol | The three-dimensional crystal structure of cholera toxin. | 251 | 1995 |
| 1LT3 | F.van den Akker, I.K.Feil, C.Roach, A.A.Platas, E.A.Merritt, W.G.Hol | 2644 | 9416616 | Protein Sci | Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit. | 6 | 1997 |
| 1LT4 | F.van den Akker, M.Pizza, R.Rappuoli, W.G.Hol | 2650 | 9416617 | Protein Sci | Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant. | 6 | 1997 |
| 2A5D | C.J.O'Neal, M.G.Jobling, R.K.Holmes, W.G.J.Hol | 1093 | n/a | Science | Structural Basis for the Activation of Cholera Toxin by Human Arf6-GTP | 309 | 2005 |
| 2A5G | C.J.O'Neal, M.G.Jobling, R.K.Holmes, W.G.J.Hol | 1093 | n/a | Science | Structural Basis for the Activation of Cholera Toxin by Human Arf6-GTP | 309 | 2005 |
| 2A5F | C.J.O'Neal, M.G.Jobling, R.K.Holmes, W.G.J.Hol | 1093 | n/a | Science | Structural Basis for the Activation of Cholera Toxin by Human Arf6-GTP | 309 | 2005 |
| 1LTI | F.van den Akker, E.Steensma, W.G.Hol | 1184 | 8762150 | Protein Sci | Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat- labile enterotoxin from Escherichia coli. | 5 | 1996 |
| 1LTG | F.van den Akker, E.A.Merritt, M.Pizza, M.Domenighini, R.Rappuoli, W.G.Hol | 10996 | 7669757 | Biochemistry | The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit. | 34 | 1995 |
| 1LTA | E.A.Merritt, T.K.Sixma, K.H.Kalk, B.A.van Zanten, W.G.Hol | 745 | 7997185 | Mol Microbiol | Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT). | 13 | 1994 |
| 1HTL | E.A.Merritt, S.Sarfaty, M.Pizza, M.Domenighini, R.Rappuoli, W.G.Hol | 269 | 7796260 | Nat Struct Biol | Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli. | 2 | 1995 |
| 1LTT | T.K.Sixma, S.E.Pronk, K.H.Kalk, B.A.van Zanten, A.M.Berghuis, W.G.Hol | 561 | 1741035 | Nature | Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. | 355 | 1992 |
| 1LTS | T.K.Sixma, K.H.Kalk, B.A.van Zanten, Z.Dauter, J.Kingma, B.Witholt, W.G.Hol | 890 | 8478941 | J Mol Biol | Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin. | 230 | 1993 |
| 1LTB | E.A.Merritt, S.E.Pronk, T.K.Sixma, K.H.Kalk, B.A.van Zanten, W.G.Hol | 88 | 8276119 | FEBS Lett | Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution. | 337 | 1994 |
| 1TII | F.van den Akker, S.Sarfaty, E.M.Twiddy, T.D.Connell, R.K.Holmes, W.G.Hol | 665 | 8805549 | Structure | Crystal structure of a new heat-labile enterotoxin, LT-IIb. | 4 | 1996 |
| 1RDP | J.C.Pickens, D.D.Mitchell, J.Liu, X.Tan, Z.Zhang, C.L.Verlinde, W.G.Hol, E.Fan | 1205 | 15380181 | Chem.Biol. | Nonspanning Bivalent Ligands as Improved Surface Receptor Binding Inhibitors of the Cholera Toxin B Pentamer. | 11 | 2004 |
| 1LLR | E.A.Merritt, Z.Zhang, J.C.Pickens, M.Ahn, W.G.J.Hol, E.Fan | 8818 | 12137534 | J.Am.Chem.Soc. | Characterization and Crystal Structure of a High-Affinity Pentavalent Receptor-Binding Inhibitor for Cholera Toxin and E. Coli Heat-Labile Enterotoxin | 124 | 2002 |
| 1RD9 | J.C.Pickens, D.D.Mitchell, J.Liu, X.Tan, Z.Zhang, C.L.Verlinde, W.G.Hol, E.Fan | 1205 | 15380181 | Chem.Biol. | Nonspanning Bivalent Ligands as Improved Surface Receptor Binding Inhibitors of the Cholera Toxin B Pentamer. | 11 | 2004 |
| 1PZK | D.D.Mitchell, J.C.Pickens, K.Korotkov, E.Fan, W.G.J.Hol | 907 | 14980603 | Bioorg.Med.Chem. | 3,5-Substituted Phenyl Galactosides as Leads in Designing Effective Cholera Toxin Antagonists; Synthesis and Crystallographic Studies | 12 | 2004 |
| 1PZJ | D.D.Mitchell, J.C.Pickens, K.Korotkov, E.Fan, W.G.J.Hol | 907 | 14980603 | Bioorg.Med.Chem. | 3,5-Substituted Phenyl Galactosides as Leads in Designing Effective Cholera Toxin Antagonists; Synthesis and Crystallographic Studies | 12 | 2004 |
| 1RCV | J.C.Pickens, D.D.Mitchell, J.Liu, X.Tan, Z.Zhang, C.L.Verlinde, W.G.Hol, E.Fan | 1205 | 15380181 | Chem.Biol. | Nonspanning Bivalent Ligands as Improved Surface Receptor Binding Inhibitors of the Cholera Toxin B Pentamer. | 11 | 2004 |
| 1MD2 | Z.Zhang, E.A.Merritt, M.Ahn, C.Roach, Z.Hou, C.L.Verlinde, W.G.Hol, E.Fan | 12991 | 12405825 | J.Am.Chem.Soc. | Solution and Crystallographic Studies of Branched Multivalent Ligands that Inhibit the Receptor-Binding of Cholera Toxin. | 124 | 2002 |
| 1RF2 | J.C.Pickens, D.D.Mitchell, J.Liu, X.Tan, Z.Zhang, C.L.Verlinde, W.G.Hol, E.Fan | 1205 | 15380181 | Chem.Biol. | Nonspanning Bivalent Ligands as Improved Surface Receptor Binding Inhibitors of the Cholera Toxin B Pentamer. | 11 | 2004 |
| 1EEI | E.Fan, E.A.Merritt, Z.Zhang, J.C.Pickens, C.Roach, M.Ahn, W.G.J.Hol | 201 | 11173465 | Acta Crystallogr., Sect.D | Exploration of the Gm1 Receptor-Binding Site of Heat-Labile Enterotoxin and Cholera Toxin by Phenyl-Ring-Containing Galactose Derivatives | 57 | 2001 |
| 1JR0 | J.C.Pickens, E.A.Merritt, M.Ahn, C.L.Verlinde, W.G.J.Hol, E.Fan | 215 | 11880036 | Chem.Biol. | Anchor-Based Design of Improved Cholera Toxin and E. Coli Heat-Labile Enterotoxin Receptor Binding Antagonists that Display Multiple Binding Modes | 9 | 2002 |
| 1FGB | R.G.Zhang, M.L.Westbrook, E.M.Westbrook, D.L.Scott, Z.Otwinowski, P.R.Maulik, R.A.Reed, G.G.Shipley | 550 | 7658472 | J Mol Biol | The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid. | 251 | 1995 |
| 2CHB | E.A.Merritt, S.Sarfaty, M.G.Jobling, T.Chang, R.K.Holmes, T.R.Hirst, W.G.Hol | 1516 | 9232653 | Protein Sci | Structural studies of receptor binding by cholera toxin mutants. | 6 | 1997 |
| 1CHQ | E.A.Merritt, S.Sarfaty, T.T.Chang, L.M.Palmer, M.G.Jobling, R.K.Holmes, W.G.Hol | 561 | 8590017 | Structure | Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. | 3 | 1995 |
| 1CHP | E.A.Merritt, S.Sarfaty, T.T.Chang, L.M.Palmer, M.G.Jobling, R.K.Holmes, W.G.Hol | 561 | 8590017 | Structure | Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. | 3 | 1995 |
| 3CHB | E.A.Merritt, P.Kuhn, S.Sarfaty, J.L.Erbe, R.K.Holmes, W.G.Hol | 1043 | 9753553 | J Mol Biol | The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site. | 282 | 1998 |
| 1CT1 | E.A.Merritt, S.Sarfaty, M.G.Jobling, T.Chang, R.K.Holmes, T.R.Hirst, W.G.Hol | 1516 | 9232653 | Protein Sci | Structural studies of receptor binding by cholera toxin mutants. | 6 | 1997 |
| 1G8Z | A.T.Aman, S.Fraser, E.A.Merritt, C.Rodigherio, M.Kenny, M.Ahn, W.G.J.Hol, N.A.Williams, W.I.Lencer, T.R.Hirst | 8536 | 11447291 | Proc.Nat.Acad.Sci.USA | A Mutant Cholera Toxin B Subunit that Binds Gm1-Ganglioside But Lacks Immunomodulatory or Toxic Activity | 98 | 2001 |
| 1LTR | D.Matkovic-Calogovic, A.Loregian, M.R.D'Acunto, R.Battistutta, A.Tossi, G.Palu, G.Zanotti | 8764 | 10085117 | J Biol Chem | Crystal structure of the B subunit of Escherichia coli heat-labile enterotoxin carrying peptides with anti-herpes simplex virus type 1 activity. | 274 | 1999 |
| 1B44 | D.Matkovic-Calogovic, A.Loregian, M.R.D'Acunto, R.Battistutta, A.Tossi, G.Palu, G.Zanotti | 8764 | 10085117 | J Biol Chem | Crystal structure of the B subunit of Escherichia coli heat-labile enterotoxin carrying peptides with anti-herpes simplex virus type 1 activity. | 274 | 1999 |
| 1JQY | J.C.Pickens, E.A.Merritt, M.Ahn, C.L.Verlinde, W.G.J.Hol, E.Fan | 215 | 11880036 | Chem.Biol. | Anchor-Based Design of Improved Cholera Toxin and E. Coli Heat-Labile Enterotoxin Receptor Binding Antagonists that Display Multiple Binding Modes | 9 | 2002 |
| 1LT6 | E.A.Merritt, S.Sarfaty, I.K.Feil, W.G.Hol | 1485 | 9384564 | Structure | Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin. | 5 | 1997 |
| 1EFI | E.Fan, E.A.Merritt, Z.Zhang, J.C.Pickens, C.Roach, M.Ahn, W.G.J.Hol | 201 | 11173465 | Acta Crystallogr., Sect.D | Exploration of the Gm1 Receptor-Binding Site of Heat-Labile Enterotoxin and Cholera Toxin by Phenyl-Ring-Containing Galactose Derivatives | 57 | 2001 |
| 1DJR | W.E.Minke, J.Pickens, E.A.Merritt, E.Fan, C.L.M.J.Verlinde, W.G.J.Hol | 795 | 10930826 | Acta Crystallogr., Sect.D | Structure of M-Carboxyphenyl-Alpha-D-Galactopyranoside Complexed to Heat- Labile Enterotoxin at 1.3 A Resolution: Surprising Variations in Ligand- Binding Modes | 56 | 2000 |
| 1LT5 | E.A.Merritt, S.Sarfaty, I.K.Feil, W.G.Hol | 1485 | 9384564 | Structure | Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin. | 5 | 1997 |
| 1EEF | E.Fan, E.A.Merritt, Z.Zhang, J.C.Pickens, C.Roach, M.Ahn, W.G.J.Hol | 201 | 11173465 | Acta Crystallogr., Sect.D | Exploration of the Gm1 Receptor-Binding Site of Heat-Labile Enterotoxin and Cholera Toxin by Phenyl-Ring-Containing Galactose Derivatives | 57 | 2001 |
| 1PZI | D.D.Mitchell, J.C.Pickens, K.Korotkov, E.Fan, W.G.J.Hol | 907 | 14980603 | Bioorg.Med.Chem. | 3,5-Substituted Phenyl Galactosides as Leads in Designing Effective Cholera Toxin Antagonists; Synthesis and Crystallographic Studies | 12 | 2004 |
| 1FD7 | E.Fan, E.A.Merritt, Z.Zhang, J.Pickens, C.Roach, M.Ahn, W.G.J.Hol | 201 | 11173465 | Acta Crystallogr., Sect.D | Exploration of the Gm1 Receptor Binding Site of Heat-Labile Enterotoxin and Cholera Toxin by Phenyl Ring-Containing Galactose Derivatives | 57 | 2001 |
| 1TET | M.Shoham | 1169 | 7690406 | J Mol Biol | Crystal structure of an anticholera toxin peptide complex at 2.3 A. | 232 | 1993 |
| 1W7O | I.Correia, C.Paquete, A.V.Coelho, C.Almeida, T.Catarino, R.Louro, C.Frazao, L.Saraiva, M.A.Carrondo, D.Turner, A.Xavier | 52227 | n/a | J.Biol.Chem. | Proton-Assisted Two-Electron Transfer in Natural Variants of Tetraheme Cytochromes from Desulfomicrobium Sp | 279 | 2004 |
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