Virtuelle (Nano) Welten: PDB Molecule of the Month 56: Caspase

PDB ID	Authors	First Page	PubMed ID	Journal Name	Citation Title	Volume No	Publication Year

1BMQ	Y.Okamoto, H.Anan, E.Nakai, K.Morihira, Y.Yonetoku, H.Kurihara, H.Sakashita, Y.Terai, M.Takeuchi, T.Shibanuma, Y.Isomura	11	9987822	Chem.Pharm.Bull.	Peptide Base Interleukin-1Beta Converting Enzyme (Ice) Inhibitors : Synthesis, Structure Activity Relationship and Crystallographic Study of Ice-Inhibitor Complex	47	1999
1C15	P.Zhou, J.Chou, R.S.Olea, J.Yuan, G.Wagner	11265	10500165	Proc.Nat.Acad.Sci.USA	Solution Structure of Apaf-1 Card and its Interaction with Caspase-9 Card: A Structural Basis for Specific Adaptor/Caspase Interaction	96	1999
1C9F	K.Uegaki, T.Otomo, H.Sakahira, M.Shimizu, N.Yumoto, Y.Kyogoku, S.Nagata, T.Yamazaki	1121	10764577	J.Mol.Biol.	Structure of the Cad Domain of Caspase-Activated DNase and Interaction with the Cad Domain of its Inhibitor	297	2000
1CVR	A.Eichinger, H.-G.Beisel, U.Jacob, R.Huber, F.J.Medrano, A.Banbula, J.Potempa, J.Travis, W.Bode	5453	10523290	Embo J.	Crystal Structure of Gingipain R: An Arg-Specific Bacterial Cysteine Proteinase with a Caspase-Like Fold	18	1999
1CWW	C.L.Day, C.Dupont, M.Lackmann, D.L.Vaux, M.G.Hinds	1125	10578182	Cell Death Differ.	Solution Structure and Mutagenesis of the Caspase Recruitment Domain (Card) from Apaf-1	6	1999
1CY5	D.E.Vaughn, J.Rodriguez, Y.Lazebnik, L.Joshua-Tor	439	10543941	J.Mol.Biol.	Crystal Structure of the Apaf-1 Caspase Recruitment Domain: An Alpha-Helical Greek Key Fold for Apoptotic Signaling	293	1999
1F0C	M.Renatus, Q.Zhou, H.R.Stennicke, S.J.Snipas, D.Turk, L.A.Bankston, R.C.Liddington, G.S.Salvesen	789	10903953	Structure Fold Des.	Crystal Structure of the Apoptotic Suppressor Crma in its Cleaved Form	8	2000
1F2R	T.Otomo, H.Sakahira, K.Uegaki, S.Nagata, T.Yamazaki	658	10932250	Nat.Struct.Biol.	Structure of the Heterodimeric Complex between Cad Domains of Cad and Icad	7	2000
1FEW	J.Chai, C.Du, J.W.Wu, S.Kyin, X.Wang, Y.Shi	855	10972280	Nature	Structural and Biochemical Basis of Apoptotic Activation by Smac/Diablo	406	2000
1FQ3	E.Estebanez-Perpina, P.Fuentes-Prior, D.Belorgey, M.Braun, R.Kiefersauer, K.Maskos, R.Huber, H.Rubin, W.Bode	1203	11209755	Biol.Chem.	Crystal Structure of the Caspase Activator Human Granzyme B, a Proteinase Highly Specific for an Asp-P1 Residue	381	2000
1G3F	Z.Liu, C.Sun, E.T.Olejniczak, R.P.Meadows, S.F.Betz, T.Oost, J.Herrmann, J.C.Wu, S.W.Fesik	1004	11140637	Nature	Structural Basis for Binding of Smac/Diablo to the Xiap Bir3 Domain.	408	2000
1GFW	D.Lee, G.Chan, K.S.Vaidya, T.A.Francis, D.P.Nadeau, M.W.Lark, M.Gowen, K.Kikly, J.D.Winkler, C.-M.Sung, S.A.Long, J.L.Adams, C.Debouck, S.Richardson, M.A.Levy, W.E.Dewolf, Jr., P.M.Keller, T.Tomaszek, M.S.Head, M.D.Ryan, R.C.Haltiwanger, P.- H.Liang, C.A.Janson, P.J.Mcdevi	16007	n/a	J.Biol.Chem.	Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 which Inhibit Apoptosis and Maintain Cell Functionality	275	2000
1I3O	S.J.Riedl, M.Renatus, R.Schwarzenbacher, Q.Zhou, C.Sun, S.W.Fesik, R.C.Liddington, G.S.Salvesen	791	11257232	Cell (Cambridge,Mass.)	Structural Basis for the Inhibition of Caspase 3 by Xiap	104	2001
1I3P	W.P.Dela Cruz, P.D.Friesen, A.J.Fisher	32933	11402050	J.Biol.Chem.	Crystal Structure of Baculovirus P35 Reveals a Novel Conformational Change in the Reactive Site Loop After Caspase Cleavage	276	2001
1I3S	W.P.Dela Cruz, P.D.Friesen, A.J.Fisher	32933	11402050	J.Biol.Chem.	Crystal Structure of Baculovirus P35 Reveals a Novel Conformational Change in the Reactive Site Loop After Caspase Cleavage	276	2001
1I4O	Y.Huang, Y.C.Park, R.L.Rich, D.Segal, D.G.Myszka, H.Wu	781	11257231	Cell (Cambridge,Mass.)	Structural Basis of Caspase Inhibition by Xiap: Differential Roles of the Linker Versus the Bir Domain	104	2001
1I51	J.Chai, E.Shiozaki, S.M.Srinivasula, Q.Wu, P.Dataa, E.S.Alnemri, Y.Shi	769	11257230	Cell (Cambridge,Mass.)	Structural Basis of Caspase-7 Inhibition by Xiap	104	2001
1IBX	P.Zhou, A.A.Lugovskoy, J.S.Mccarty, P.Li, G.Wagner	6051	11371636	Proc.Nat.Acad.Sci.USA	Solution Structure of Dff40 and Dff45 N-Terminal Domain Complex and Mutual Chaperone Activity of Dff40 and Dff45	98	2001
1JD4	J.W.Wu, A.E.Cocina, J.Chai, B.A.Hay, Y.Shi	95	11511363	Mol. Cell	Structural Analysis of a Functional Diap1 Fragment Bound to Grim and Hid Peptides	8	2001
1JD5	J.W.Wu, A.E.Cocina, J.Chai, B.A.Hay, Y.Shi	95	11511363	Mol. Cell	Structural Analysis of a Functional Diap1 Fragment Bound to Grim and Hid Peptides	8	2001
1JD6	J.W.Wu, A.E.Cocina, J.Chai, B.A.Hay, Y.Shi	95	11511363	Mol. Cell	Structural Analysis of a Functional Diap1 Fragment Bound to Grim and Hid Peptides	8	2001
1JXQ	M.Renatus, H.R.Stennicke, F.L.Scott, R.C.Liddington, G.S.Salvesen	14250	11734640	Proc.Nat.Acad.Sci.USA	Dimer Formation Drives the Activation of the Cell Death Protease Caspase 9.	98	2001
1K86	J.Chai, Q.Wu, E.Shiozaki, S.M.Srinivasula, E.S.Alnemri, Y.Shi	299	11701129	Cell (Cambridge,Mass.)	Crystal Structure of a Procaspase-7 Zymogen: Mechanisms of Activation and Substrate Binding	107	2001
1KMC	S.J.Riedl, G.S.Salvesen, W.Bode	n/a	n/a	To be Published	Crystal Structure of the Caspase-7 / Xiap-Bir2 Complex	n/a	n/a
1LCY	W.Li, S.M.Srinivasula, J.Chai, P.Li, J.W.Wu, Z.Zhang, E.S.Alnemri, Y.Shi	436	11967569	Nat.Struct.Biol.	Structural Insights Into the Pro-Apoptotic Function of Mitochondrial Serine Protease Htra2/Omi	9	2002
1M72	C.M.Forsyth, D.Lemongello, D.J.Lacount, P.D.Friesen, A.J.Fisher	7001	n/a	J.Biol.Chem.	Crystal Structure of an Invertebrate Caspase	279	2004
1NW9	E.N.Shiozaki, J.Chai, D.J.Rigotti, S.J.Riedl, P.Li, S.M.Srinivasula, E.S.Alnemri, R.Fairman, Y.Shi	519	12620238	Mol.Cell	Mechanism of Xiap-Mediated Inhibition of Caspase-9	11	2003
1P35	A.J.Fisher, W.d.Cruz, S.J.Zoog, C.L.Schneider, P.D.Friesen	2031	10205157	EMBO J	Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition.	18	1999
1PN5	S.Hiller, A.Kohl, F.Fiorito, T.Herrmann, G.Wider, J.Tschopp, M.G.Grütter, K.Wuthrich	1199	14527388	Structure	NMR Structure of the Apoptosis- and Inflammation-Related Nalp1 Pyrin Domain	11	2003
1PYO	A.Schweizer, C.Briand, M.G.Grütter	42441	12920126	J.Biol.Chem.	Crystal Structure of Caspase-2, Apical Initiator of the Intrinsic Apoptotic Pathway.	278	2003
1Q4Q	J.Chai, N.Yan, J.R.Huh, J.-W.Wu, W.Li, B.A.Hay, Y.Shi	892	14517550	Nat.Struct.Biol.	Molecular Mechanism of Reaper-Grim-Hid-Mediated Suppression of Diap1-Dependent Dronc Ubiquitination	10	2003
1QTN	W.Watt, K.A.Koeplinger, A.M.Mildner, R.L.Heinrikson, A.G.Tomasselli, K.D.Watenpaugh	1135	10508785	Structure (London)	The Atomic-Resolution Structure of Human Caspase-8, a Key Activator of Apoptosis	7	1999
1SDZ	N.Yan, J.W.Wu, J.Chai, W.Li, Y.Shi	420	n/a	Nat.Struct.Mol.Biol.	Molecular Mechanisms of Drice Inhibition by Diap1 and Removal of Inhibition by Reaper, Hid, and Grim	11	2004
1SE0	N.Yan, J.W.Wu, J.Chai, Li W., Y.Shi	420	n/a	Nat.Struct.Mol.Biol.	Molecular Mechanisms of Drice Inhibition by Diap1 and Removal of Inhibition by Reaper, Hid, and Grim	11	2004
1V0D	E.-J.Woo, Y.-G.Kim, M.-S.Kim, W.-D.Han, S.Shin, H.Robinson, S.-Y.Park, B.-H.Oh	531	n/a	Molecular Cell	Structural Mechanism for Inactivation and Activation of Cad/Dff40 in the Apoptotic Pathway	14	2004
2YGS	H.Qin, S.Srinivasula, G.Wu, T.Fernandes-Alnemri, E.Alnemri, Y.Shi	549	10376594	Nature	Structural Basis of Procaspase-9 Recruitment by Apoptotic Protease Activating Factor 1	399	1999
3CRD	J.J.Chou, H.Matsuo, H.Duan, G.Wagner	171	9695946	Cell	Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.	94	1998
3YGS	H.Qin, S.Srinivasula, G.Wu, T.Fernandes-Alnemri, E.Alnemri, Y.Shi	549	10376594	Nature	Structural Basis of Procaspase-9 Recruitment by Apoptotic Protease-Activating Factor 1	399	1999

Caspases