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Potassium Channels
| PDB ID | Authors | First Page | Medline Link | Journal Name | Title | Volume No | Publication Year |
| 1A68 | A.Kreusch, P.J.Pfaffinger, C.F.Stevens, S.Choe | 945 | 9582078 | Nature | Crystal structure of the tetramerization domain of the Shaker potassium channel. | 392 | 1998 |
| 1ACW | E.Blanc, V.Fremont, P.Sizun, S.Meunier, J.Van Rietschoten, A.Thevand, J.M.Bernassau, H.Darbon | 359 | 8778783 | Proteins | Solution structure of P01, a natural scorpion peptide structurally analogous to scorpion toxins specific for apamin-sensitive potassium channel. | 24 | 1996 |
| 1AGT | A.M.Krezel, C.Kasibhatla, P.Hidalgo, R.MacKinnon, G.Wagner | 1478 | 8520473 | Protein Sci | Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. | 4 | 1995 |
| 1AV3 | M.J.Scanlon, D.Naranjo, L.Thomas, P.F.Alewood, R.J.Lewis, D.J.Craik | 1585 | 9438859 | Structure | Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA. | 5 | 1997 |
| 1B4G | C.Antz, T.Bauer, H.Kalbacher, R.Frank, M.Covarrubias, H.R.Kalbitzer, J.P.Ruppersberg, T.Baukrowitz, B.Fakler | 146 | 10048926 | Nat Struct Biol | Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate. | 6 | 1999 |
| 1B4I | C.Antz, T.Bauer, H.Kalbacher, R.Frank, M.Covarrubias, H.R.Kalbitzer, J.P.Ruppersberg, T.Baukrowitz, B.Fakler | 146 | 10048926 | Nat Struct Biol | Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate. | 6 | 1999 |
| 1BAH | J.Song, B.Gilquin, N.Jamin, E.Drakopoulou, M.Guenneugues, M.Dauplais, C.Vita, A.Menez | 3760 | 9092804 | Biochemistry | NMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packing. | 36 | 1997 |
| 1BEI | K.Kalman, M.W.Pennington, M.D.Lanigan, A.Nguyen, H.Rauer, V.Mahnir, K.Paschetto, W.R.Kem, S.Grissmer, G.A.Gutman, E.P.Christian, M.D.Cahalan, R.S.Norton, K.G.Chandy | 32697 | 9830012 | J Biol Chem | ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. | 273 | 1998 |
| 1BGK | M.Dauplais, A.Lecoq, J.Song, J.Cotton, N.Jamin, B.Gilquin, C.Roumestand, C.Vita, C.L.C.de Medeiros, E.G.Rowan, A.L.Harvey, A.Menez | 4302 | 9020148 | J Biol Chem | On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. | 272 | 1997 |
| 1BIG | E.Blanc, R.Romi-Lebrun, O.Bornet, T.Nakajima, H.Darbon | 12412 | 9730813 | Biochemistry | Solution structure of two new toxins from the venom of the Chinese scorpion Buthus martensi Karsch blockers of potassium channels. | 37 | 1998 |
| 1BKT | J.G.Renisio, R.Romi-Lebrun, E.Blanc, O.Bornet, T.Nakajima, H.Darbon | n/a | ( 1BKT ) | To be Published | Solution Structure and Structure-Activity Relationships of Ktx-Like Toxin from the Venom of the Chinese Scorpion Buthus Martensii Karsch | n/a | n/a |
| 1BL8 | D.A.Doyle, J.Morais Cabral, R.A.Pfuetzner, A.Kuo, J.M.Gulbis, S.L.Cohen, B.T.Chait, R.MacKinnon | 69 | 9525859 | Science | The structure of the potassium channel: molecular basis of K+ conduction and selectivity. | 280 | 1998 |
| 1BUN | P.D.Kwong, N.Q.McDonald, P.B.Sigler, W.A.Hendrickson | 1109 | 8590005 | Structure | Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action. | 3 | 1995 |
| 1BYW | J.H.M.Cabral, A.Lee, S.L.Cohen, B.T.Chait, M.Li, R.Mackinnon | 649 | ( 1BYW ) | Cell | Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain. | 95 | 1998 |
| 1C2U | M.W.Pennington, M.D.Lanigan, K.Kalman, V.M.Manhir, H.Rauer, C.T.Mcvaugh, D.Behm, D.Donaldson, K.G.Chandy, W.R.Kem, R.S.Norton | 14549 | ( 1C2U ) | Biochemistry | Role of Disulfide Bonds in the Structure and Potassium Channel Blocking Activity of Shk Toxin | 38 | 1999 |
| 1C49 | K.C.Klenk, T.C.Tenenholz, D.R.Matteson, R.S.Rogowski, M.P.Blaustein, D.J.Weber | 441 | ( 1C49 ) | Proteins: Struct., Funct., Genet. | Structural and Functional Differences of Two Toxins from the Scorpion Pandinus Imperator | 38 | 2000 |
| 1D1H | H.Takahashi, J.I.Kim, K.Sato, K.J.Swartz, I.Shimada, H.J.Min | 771 | ( 1D1H ) | J.Mol.Biol. | Solution Structure of Hanatoxin1, a Gating Modifier of Voltage-Dependent K(+) Channels: Common Surface Features of Gating Modifier Toxins | 297 | 2000 |
| 1DEM | J.M.Lancelin, M.F.Foray, M.Poncin, M.Hollecker, D.Marion | 246 | 7544683 | Nat Struct Biol | Proteinase inhibitor homologues as potassium channel blockers. | 1 | 1994 |
| 1DEN | J.M.Lancelin, M.F.Foray, M.Poncin, M.Hollecker, D.Marion | 246 | 7544683 | Nat Struct Biol | Proteinase inhibitor homologues as potassium channel blockers. | 1 | 1994 |
| 1DSX | D.L.Minor Jr., Y.-F.Lin, B.C.Mobley, A.Avelar, Y.N.Jan, L.Y.Jan, J.M.Berger | 657 | ( 1DSX ) | Cell (Cambridge,Mass.) | The Polar T1 Interface is Linked to Conformational Changes that Open the Voltage-Gated Potassium Channel | 102 | 2000 |
| 1DU9 | Y.Xu, J.Wu, J.Pei, Y.Shi, Y.Ji, Q.Tong | 13669 | ( 1DU9 ) | Biochemistry | Solution Structure of Bmp02, a New Potassium Channel Blocker from the Venom of the Chinese Scorpion Buthus Martensi Karsch | 39 | 2000 |
| 1EMX | C.Bernard, C.Legros, G.Ferrat, U.Bishoff, A.Marquardt, O.Pongs, H.Darbon | 2059 | ( 1EMX ) | Protein Sci. | Solution Structure of Hptx2, a Toxin from Heteropodidae Venatoria Spider that Blocks Kv4.2 Potassium Channel | 9 | 2000 |
| 1EOD | S.J.Cushman, M.H.Nanao, A.W.Jahng, D.Derubeis, S.Choe, P.J.Pfaffinger | 403 | ( 1EOD ) | Nat.Struct.Biol. | Voltage-Dependent Activation of Potassium Channels is Coupled to T1 Domain Structure. | 7 | 2000 |
| 1EOE | S.J.Cushman, M.H.Nanao, A.W.Jahng, D.Derubeis, S.Choe, P.J.Pfaffinger | 403 | ( 1EOE ) | Nat.Struct.Biol. | Voltage-Dependent Activation of Potassium Channels is Coupled to T1 Domain Structure | 7 | 2000 |
| 1EOF | S.J.Cushman, M.H.Nanao, A.W.Jahng, D.Derubeis, S.Choe, P.J.Pfaffinger | 403 | ( 1EOF ) | Nat.Struct.Biol. | Voltage-Dependent Activation of Potassium Channels is Coupled to T1 Domain Structure. | 7 | 2000 |
| 1EXB | J.M.Gulbis, M.Zhou, S.Mann, R.Mackinnon | 123 | ( 1EXB ) | Science | Structure of the Cytoplasmic Beta Subunit--T1 Assembly of Voltage-Dependent K+ Channels | 289 | 2000 |
| 1F6G | D.M.Cortes, L.G.Cuello, E.Perozo | 165 | ( 1F6G ) | J.Gen.Physiol. | Molecular Architecture of Full-Length Kcsa: Role of Cytoplasmic Domains in Ion Permeation and Activation Gating | 117 | 2001 |
| 1G4Y | M.A.Schumacher, A.Rivard, H.P.Bachinger, J.P.Adelman | 1120 | ( 1G4Y ) | Nature | Structure of the Gating Domain of a Ca2+-Activated K+ Channel Complexed with Ca2+/Calmodulin | 410 | 2001 |
| 1HO2 | O.Ohlenschlager, H.Hojo, R.Ramachandran, M.Gorlach, P.I.Haris | 2995 | ( 1HO2 ) | Biophys.J. | Three-Dimensional Structure of the S4-S5 Segment of the Shaker Potassium Channel | 82 | 2002 |
| 1HO7 | O.Ohlenschlager, H.Hojo, R.Ramachandran, M.Gorlach, P.I.Haris | 2995 | ( 1HO7 ) | Biophys.J. | Three-Dimensional Structure of the S4-S5 Segment of the Shaker Potassium Channel | 82 | 2002 |
| 1HP2 | K.C.Ellis, T.C.Tenenholz, H.Jerng, M.Hayhurst, C.S.Dudlak, W.F.Gilly, M.P.Blaustein, D.J.Weber | 5942 | ( 1HP2 ) | Biochemistry | Interaction of a Toxin from the Scorpion Tityus Serrulatus with a Cloned K+ Channel from Squid (Sqkv1A) | 40 | 2001 |
| 1HP9 | K.N.Srinivasan, V.Sivaraja, I.Huys, T.Sasaki, B.Cheng, T.K.S.Kumar, K.Sato, J.Tytgat, C.Yu, C.S.Brian Chia, S.Ranganathan, J.H.Bowie, R.M.Kini, P.Gopalakrishnakone | 30040 | ( 1HP9 ) | J.Biol.Chem. | Kappa-Hefutoxin1, a Novel Toxin from the Scorpion Heterometrus Fulvipes with Unique Structure and Function: Importance of the Functional Diad in Potassium Channel Selectivity | 277 | 2002 |
| 1ID1 | Y.Jiang, A.Pico, M.Cadene, B.T.Chait, R.Mackinnon | 593 | ( 1ID1 ) | Neuron | Structure of the Rck Domain from the E.Coli K+ Channel and Demonstration of its Presence in the Human Bk Channel | 29 | 2001 |
| 1J95 | J.H.Morais Cabral, R.Mackinnon, M.Zhou | n/a | ( 1J95 ) | To be Published | Potassium Channel Receptor Site for the Inactivation Gate and Quaternary Amine Inhibitors | n/a | n/a |
| 1JO6 | D.Bentrop, M.Beyermann, R.Wissmann, B.Fakler | 42116 | ( 1JO6 ) | J.Biol.Chem. | NMR Structure of the 'Ball-and-Chain' Domain of Kcnmb2, the Beta2-Subunit of Large Conductance Ca2+-and Voltage-Activated Potassium Channels | 276 | 2001 |
| 1JQ1 | Y.-S.Liu, P.Sompornpisut, E.Perozo | 883 | ( 1JQ1 ) | Nat.Struct.Biol. | Structure of the Kcsa Channel Intracellular Gate in the Open State | 8 | 2001 |
| 1JQ2 | Y.-S.Liu, P.Sompornpisut, E.Perozo | 883 | ( 1JQ2 ) | Nat.Struct.Biol. | Structure of the Kcsa Channel Intracellular Gate in the Open State | 8 | 2001 |
| 1JVM | J.H.Morais-Cabral, Y.Zhou, R.Mackinnon | 37 | ( 1JVM ) | Nature | Energetic Optimization of Ion Conduction Rate by the K+ Selectivity Filter | 414 | 2001 |
| 1K4C | Y.Zhou, J.H.Morais-Cabral, A.Kaufman, R.Mackinnon | 43 | ( 1K4C ) | Nature | Chemistry of Ion Coordination and Hydration Revealed by a K+ Channel-Fab Complex at 2.0 A Resolution | 414 | 2001 |
| 1K4D | Y.Zhou, J.H.Morais-Cabral, A.Kaufman, R.Mackinnon | 43 | ( 1K4D ) | Nature | Chemistry of Ion Coordination and Hydration Revealed by a K+ Channel-Fab Complex at 2.0 A Resolution | 414 | 2001 |
| 1KCP | P.Savarin, M.Guenneugues, B.Gilquin, H.Lamthanh, S.Gasparini, S.Zinn-Justin, A.Menez | 5407 | 9548922 | Biochemistry | Three-dimensional structure of kappa-conotoxin PVIIA, a novel potassium channel-blocking toxin from cone snails. | 37 | 1998 |
| 1KKD | R.Wissmann, W.Bildl, H.Neumann, A.F.Rivard, N.Kloecker, D.Weitz, U.Schulte, J.P.Adelman, D.Bentrop, B.Fakler | 4558 | ( 1KKD ) | J.Biol.Chem. | A Helical Region in the C-Terminus of Small-Conductance Ca2+-Activated K+ Channels Controls Assembly with Apo-Calmodulin | 277 | 2002 |
| 1KTX | I.Fernandez, R.Romi, S.Szendeffy, M.F.Martin-Eauclaire, H.Rochat, J.Van Rietschoten, M.Pons, E.Giralt | 14256 | 7524673 | Biochemistry | Kaliotoxin (1-37) shows structural differences with related potassium channel blockers. | 33 | 1994 |
| 1LIR | J.G.Renisio, Z.Lu, E.Blanc, W.Jin, J.H.Lewis, O.Bornet, H.Darbon | 417 | 10081954 | Proteins | Solution structure of potassium channel-inhibiting scorpion toxin Lq2. | 34 | 1999 |
| 1LNQ | Y.Jiang, A.Lee, J.Chen, M.Cadene, B.T.Chait, R.Mackinnon | 515 | ( 1LNQ ) | Nature | Crystal Structure and Mechanism of a Calcium-Gated Potassium Channel | 417 | 2002 |
| 1N9P | M.Nishida, R.Mackinnon | 957 | ( 1N9P ) | Cell (Cambridge,Mass.) | Structural Basis of Inward Rectification: Cytoplasmic Pore of the G Protein-Gated Inward Rectifier Girk1 at 1.8 A Resolution | 111 | 2002 |
| 1PNH | S.Meunier, J.M.Bernassau, J.M.Sabatier, M.F.Martin-Eauclaire, J.Van Rietschoten, C.Cambillau, H.Darbon | 11969 | 8218272 | Biochemistry | Solution structure of P05-NH2, a scorpion toxin analog with high affinity for the apamin-sensitive potassium channel. | 32 | 1993 |
| 1QDV | D.L.Minor Jr., Y.-F.Lin, B.C.Mobley, A.Avelar, Y.N.Jan, L.Y.Jan, J.M.Berger | 657 | ( 1QDV ) | Cell (Cambridge,Mass.) | The Polar T1 Interface is Linked to Conformational Changes that Open the Voltage-Gated Potassium Channel | 102 | 2000 |
| 1QDW | D.L.Minor Jr., Y.-F.Lin, B.C.Mobley, A.Avelar, Y.N.Jan, L.Y.Jan, J.M.Berger | 657 | ( 1QDW ) | Cell (Cambridge,Mass.) | The Polar T1 Interface is Linked to Conformational Changes that Open the Voltage-Gated Potassium Channel | 102 | 2000 |
| 1QKY | M.Delepierre, A.Prochnicka-Chalufour, J.Boisbouvier, L.D.Possani | 16756 | ( 1QKY ) | Biochemistry | Pi7, an Orphan Peptide from the Scorpion Pandinus Imperator: A 1H NMR Analysis Using a Nano-NMR Probe | 38 | 1999 |
| 1QRQ | J.M.Gulbis, S.Mann, R.Mackinnon | 943 | ( 1QRQ ) | Cell (Cambridge,Mass.) | Structure of a Voltage-Dependent K+ Channel Beta Subunit | 97 | 1999 |
| 1QUZ | P.Savarin, R.Romi-Lebrun, S.Zinn-Justin, B.Lebrun, T.Nakajima, B.Gilquin, A.Menez | 2672 | ( 1QUZ ) | Protein Sci. | Structural and Functional Consequences of the Presence of a Fourth Disulfide Bridge in the Scorpion Short Toxins: Solution Structure of the Potassium Channel Scorpion Toxin Hstx1 | 8 | 1999 |
| 1RON | S.A.Monks, G.Karagianis, G.J.Howlett, R.S.Norton | 379 | 9008359 | J Biomol NMR | Solution structure of human neuropeptide Y. | 8 | 1996 |
| 1ROO | J.E.Tudor, P.K.Pallaghy, M.W.Pennington, R.S.Norton | 317 | 8599755 | Nat Struct Biol | Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone. | 3 | 1996 |
| 1SCO | V.A.Jaravine, D.E.Nolde, M.J.Reibarkh, Y.V.Korolkova, S.A.Kozlov, K.A.Pluzhnikov, E.V.Grishin, A.S.Arseniev | 1223 | 9063870 | Biochemistry | Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom. | 36 | 1997 |
| 1SCY | J.C.Martins, F.J.Van de Ven, F.A.Borremans | 590 | 7473736 | J Mol Biol | Determination of the three-dimensional solution structure of scyllatoxin by 1H nuclear magnetic resonance. | 253 | 1995 |
| 1SXM | M.Dauplais, B.Gilquin, L.D.Possani, G.Gurrola-Briones, C.Roumestand, A.Menez | 16563 | 8527429 | Biochemistry | Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins. | 34 | 1995 |
| 1T1D | K.A.Bixby, M.H.Nanao, N.V.Shen, A.Kreusch, H.Bellamy, P.J.Pfaffinger, S.Choe | 38 | 9886290 | Nat Struct Biol | Zn2+-binding and molecular determinants of tetramerization in voltage- gated K+ channels. | 6 | 1999 |
| 1TSK | E.Blanc, C.Lecomte, J.V.Rietschoten, J.M.Sabatier, H.Darbon | 359 | 9365990 | Proteins | Solution structure of TsKapa, a charybdotoxin-like scorpion toxin from Tityus serrulatus with high affinity for apamin-sensitive Ca(2+)-activated K+ channels. | 29 | 1997 |
| 1TXM | E.Blanc, J.M.Sabatier, R.Kharrat, S.Meunier, M.el Ayeb, J.Van Rietschoten, H.Darbon | 321 | 9365987 | Proteins | Solution structure of maurotoxin, a scorpion toxin from Scorpio maurus, with high affinity for voltage-gated potassium channels. | 29 | 1997 |
| 1ZTN | C.Antz, M.Geyer, B.Fakler, M.K.Schott, H.R.Guy, R.Frank, J.P.Ruppersberg, H.R.Kalbitzer | 272 | 9000078 | Nature | NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. | 385 | 1997 |
| 1ZTO | C.Antz, M.Geyer, B.Fakler, M.K.Schott, H.R.Guy, R.Frank, J.P.Ruppersberg, H.R.Kalbitzer | 272 | 9000078 | Nature | NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. | 385 | 1997 |
| 2BMT | E.Blanc, R.Romi-Lebrun, O.Bornet, T.Nakajima, H.Darbon | 12412 | 9730813 | Biochemistry | Solution structure of two new toxins from the venom of the Chinese scorpion Buthus martensi Karsch blockers of potassium channels. | 37 | 1998 |
| 2KTX | M.Gairi, R.Romi, I.Fernandez, H.Rochat, M.-F.Martin-Eauclaire, J.Van Rietschtoten, M.Pons, E.Giralt | n/a | ( 2KTX ) | To be Published | 3D-Structure of Kaliotoxin: Is Residue 34 a Key for Channel Selectivity? | n/a | n/a |
| 2PTA | T.C.Tenenholz, R.S.Rogowski, J.H.Collins, M.P.Blaustein, D.J.Weber | 2763 | 9062103 | Biochemistry | Solution structure for Pandinus toxin K-alpha (PiTX-K alpha), a selective blocker of A-type potassium channels. | 36 | 1997 |
| 3KVT | K.A.Bixby, M.H.Nanao, N.V.Shen, A.Kreusch, H.Bellamy, P.J.Pfaffinger, S.Choe | 38 | 9886290 | Nat Struct Biol | Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels. | 6 | 1999 |
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