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Dihydrofolate Reductase
| PDB ID | Authors | First Page | Journal Name | Title | Volume No | Publication Year |
| 1AI9 | M.Whitlow, A.J.Howard, D.Stewart, K.D.Hardman, L.F.Kuyper, D.P.Baccanari, M.E.Fling, R.L.Tansik | 30289 | J Biol Chem | X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex. | 272 | 1997 |
| 1AO8 | A.R.Gargaro, A.Soteriou, T.A.Frenkiel, C.J.Bauer, B.Birdsall, V.I.Polshakov, I.L.Barsukov, G.C.Roberts, J.Feeney | 119 | J Mol Biol | The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate. | 277 | 1998 |
| 1AOE | M.Whitlow, A.J.Howard, D.Stewart, K.D.Hardman, L.F.Kuyper, D.P.Baccanari, M.E.Fling, R.L.Tansik | 30289 | J Biol Chem | X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex. | 272 | 1997 |
| 1BOZ | A.Gangjee, A.P.Vidwans, A.Vasudevan, S.F.Queener, R.L.Kisliuk, V.Cody, R.Li, N.Galitsky, J.R.Luft, W.Pangborn | 3426 | J.Med.Chem. | Structure-Based Design and Synthesis of Lipophilic 2,4-Diamino-6-Substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductases and Potential Antitumor Agents | 41 | 1998 |
| 1BZF | V.I.Polshakov, B.Birdsall, T.A.Frenkiel, A.R.Gargaro, J.Feeney | 467 | Protein Sci | Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate. | 8 | 1999 |
| 1CD2 | V.Cody, N.Galitsky, D.Rak, J.R.Luft, W.Pangborn, S.F.Queener | 4303 | Biochemistry | Ligand-Induced Conformational Changes in the Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+ | 38 | 1999 |
| 1CZ3 | T.Dams, G.Auerbach, G.Bader, U.Jacob, T.Ploom, R.Huber, R.Jaenicke | 659 | J.Mol.Biol. | The Crystal Structure of Dihydrofolate Reductase from Thermotoga Maritima: Molecular Features of Thermostability | 297 | 2000 |
| 1D1G | T.Dams, G.Auerbach, G.Bader, U.Jacob, T.Ploom, R.Huber, R.Jaenicke | 659 | J.Mol.Biol. | The Crystal Structure of Dihydrofolate Reductase from Thermotoga Maritima: Molecular Features of Thermostability | 297 | 2000 |
| 1D8R | V.Cody, D.Chan, N.Galitsky, D.Rak, J.R.Luft, W.Pangborn, S.F.Queener, C.A.Laughton, M.F.Stevens | 3556 | Biochemistry | Structural Studies on Bioactive Compounds. 30. Crystal Structure and Molecular Modeling Studies on the Pneumocystis Carinii Dihydrofolate Reductase Cofactor Complex with Tab, a Highly Selective Antifolate | 39 | 2000 |
| 1DAJ | V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, A.Gangjee, R.Devraj, S.F.Queener, R.L.Blakley | 638 | Acta Crystallogr D Biol Crystallogr | Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate. | 53 | 1997 |
| 1DDR | H.P.Yennawar, G.K.Farber | n/a | n/a | n/a | n/a | n/a |
| 1DDS | H.P.Yennawar, G.K.Farber | n/a | n/a | n/a | n/a | n/a |
| 1DF7 | R.Li, R.Sirawaraporn, P.Chitnumsub, W.Sirawaraporn, J.Wooden, F.Athappilly, S.Turley, W.G.Hol | 307 | J.Mol.Biol. | Three-Dimensional Structure of M. Tuberculosis Dihydrofolate Reductase Reveals Opportunities for the Design of Novel Tuberculosis Drugs | 295 | 2000 |
| 1DG5 | R.Li, R.Sirawaraporn, P.Chitnumsub, W.Sirawaraporn, J.Wooden, F.Athappilly, S.Turley, W.G.Hol | 307 | J.Mol.Biol. | Three-Dimensional Structure of M. Tuberculosis Dihydrofolate Reductase Reveals Opportunities for the Design of Novel Tuberculosis Drugs | 295 | 2000 |
| 1DG7 | R.Li, R.Sirawaraporn, P.Chitnumsub, W.Sirawaraporn, J.Wooden, F.Athappilly, S.Turley, W.G.Hol | 307 | J.Mol.Biol. | Three-Dimensional Structure of M. Tuberculosis Dihydrofolate Reductase Reveals Opportunities for the Design of Novel Tuberculosis Drugs | 295 | 2000 |
| 1DG8 | R.Li, R.Sirawaraporn, P.Chitnumsub, W.Sirawaraporn, J.Wooden, F.Athappilly, S.Turley, W.G.Hol | 307 | J.Mol.Biol. | Three-Dimensional Structure of M. Tuberculosis Dihydrofolate Reductase Reveals Opportunities for the Design of Novel Tuberculosis Drugs | 295 | 2000 |
| 1DHF | .2.Davies 2d, T.J.Delcamp, N.J.Prendergast, V.A.Ashford, J.H.Freisheim, J.Kraut | 9467 | Biochemistry | Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. | 29 | 1990 |
| 1DHI | K.A.Brown, E.E.Howell, J.Kraut | 11753 | Proc Natl Acad Sci U S A | Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase. | 90 | 1993 |
| 1DHJ | K.A.Brown, E.E.Howell, J.Kraut | 11753 | Proc Natl Acad Sci U S A | Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase. | 90 | 1993 |
| 1DIS | W.D.Morgan, B.Birdsall, V.I.Polshakov, D.Sali, I.Kompis, J.Feeney | 11690 | Biochemistry | Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase. | 34 | 1995 |
| 1DIU | W.D.Morgan, B.Birdsall, V.I.Polshakov, D.Sali, I.Kompis, J.Feeney | 11690 | Biochemistry | Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase. | 34 | 1995 |
| 1DLR | W.S.Lewis, V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, S.K.Chunduru, H.T.Spencer, J.R.Appleman, R.L.Blakley | 5057 | J Biol Chem | Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. | 270 | 1995 |
| 1DLS | W.S.Lewis, V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, S.K.Chunduru, H.T.Spencer, J.R.Appleman, R.L.Blakley | 5057 | J Biol Chem | Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. | 270 | 1995 |
| 1DR1 | M.A.McTigue, J.F.Davies 2d., B.T.Kaufman, J.Kraut | 7264 | Biochemistry | Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin. | 31 | 1992 |
| 1DR2 | M.A.McTigue, J.F.Davies 2d., B.T.Kaufman, J.Kraut | 6855 | Biochemistry | Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes. | 32 | 1993 |
| 1DR3 | M.A.McTigue, J.F.Davies 2d., B.T.Kaufman, J.Kraut | 6855 | Biochemistry | Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes. | 32 | 1993 |
| 1DR4 | M.A.Mctigue, J.F.Davies II, B.T.Kaufman, N.-H.Xuong, J.Kraut | n/a | To be Published | Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes | n/a | n/a |
| 1DR5 | M.A.Mctigue, J.F.Davies II, B.T.Kaufman, N.-H.Xuong, J.Kraut | n/a | To be Published | Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes | n/a | n/a |
| 1DR6 | M.A.Mctigue, J.F.Davies II, B.T.Kaufman, N.-H.Xuong, J.Kraut | n/a | To be Published | Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes | n/a | n/a |
| 1DR7 | M.A.Mctigue, J.F.Davies II, B.T.Kaufman, N.-H.Xuong, J.Kraut | n/a | To be Published | Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes | n/a | n/a |
| 1DRA | C.Bystroff, J.Kraut | 2227 | Biochemistry | Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding. | 30 | 1991 |
| 1DRB | C.Bystroff, J.Kraut | 2227 | Biochemistry | Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding. | 30 | 1991 |
| 1DRE | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1DRF | C.Oefner, A.D'Arcy, F.K.Winkler | 377 | Eur J Biochem | Crystal structure of human dihydrofolate reductase complexed with folate. | 174 | 1988 |
| 1DRH | V.M.Reyes, M.R.Sawaya, K.A.Brown, J.Kraut | 2710 | Biochemistry | Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications. | 34 | 1995 |
| 1DYH | V.M.Reyes, M.R.Sawaya, K.A.Brown, J.Kraut | 2710 | Biochemistry | Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications. | 34 | 1995 |
| 1DYI | V.M.Reyes, M.R.Sawaya, K.A.Brown, J.Kraut | 2710 | Biochemistry | Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications. | 34 | 1995 |
| 1DYJ | V.M.Reyes, M.R.Sawaya, K.A.Brown, J.Kraut | 2710 | Biochemistry | Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications. | 34 | 1995 |
| 1DYR | J.N.Champness, A.Achari, S.P.Ballantine, P.K.Bryant, C.J.Delves, D.K.Stammers | 915 | Structure | The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution. | 2 | 1994 |
| 1E26 | V.Cody, N.Galitsky, D.Rak, J.R.Luft, W.Pangborn, S.F.Queener | n/a | Biochemistry, 38, 4303-4312 (1999) | Ligand Induced Conformational Changes in the Crystal Structure of Pneumocystis Carinii Dihydrofolate Reductase Complex with Folate and Nadp+ | n/a | n/a |
| 1E7W | D.Gourley, A.Schuttelkopf, G.Leonard, J.Luba, L.Hardy, S.Beverley, W.Hunter | 521 | Nat.Struct.Biol. | Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites. | 8 | 2001 |
| 1HFP | V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, R.L.Blakley, A.Gangjee | 307 | Anticancer Drug Des | Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. | 13 | 1998 |
| 1HFQ | V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, R.L.Blakley, A.Gangjee | 307 | Anticancer Drug Des | Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. | 13 | 1998 |
| 1HFR | V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, R.L.Blakley, A.Gangjee | 307 | Anticancer Drug Des | Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. | 13 | 1998 |
| 1IA1 | M.Whitlow, A.J.Howard, D.Stewart, K.D.Hardman, J.H.Chan, D.P.Baccanari, R.L.Tansik, J.S.Hong, L.F.Kuyper | n/a | To be Published | X-Ray Crystal Structures of Candida Albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in which the Dihydronicotinamide Moiety of Nadph is Displaced by an Inhibitor | n/a | n/a |
| 1IA2 | M.Whitlow, A.J.Howard, D.Stewart, K.D.Hardman, J.H.Chan, D.P.Baccanari, R.L.Tansik, J.S.Hong, L.F.Kuyper | n/a | To be Published | X-Ray Crystal Structures of Candida Albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in which the Dihydronicotinamide Moiety of Nadph is Displaced by an Inhibitor | n/a | n/a |
| 1IA3 | M.Whitlow, A.J.Howard, D.Stewart, K.D.Hardman, J.H.Chan, D.P.Baccanari, R.L.Tansik, J.S.Hong, L.F.Kuyper | n/a | To be Published | X-Ray Crystal Structures of Candida Albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in which the Dihydronicotinamide Moiety of Nadph is Displaced by an Inhibitor | n/a | n/a |
| 1IA4 | M.Whitlow, A.J.Howard, D.Stewart, K.D.Hardman, J.H.Chan, D.P.Baccanari, R.L.Tansik, J.S.Hong, L.F.Kuyper | n/a | To be Published | X-Ray Crystal Structures of Candida Albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in which the Dihydronicotinamide Moiety of Nadph is Displaced by an Inhibitor | n/a | n/a |
| 1JOL | H.Lee, V.M.Reyes, J.Kraut | 7012 | Biochemistry | Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4. | 35 | 1996 |
| 1JOM | H.Lee, V.M.Reyes, J.Kraut | 7012 | Biochemistry | Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4. | 35 | 1996 |
| 1KMS | A.E.Klon, A.Heroux, L.J.Ross, V.Pathak, C.A.Johnson, J.R.Piper, D.W.Borhani | 677 | J.Mol.Biol. | Atomic Resolution Structures of Human Dihydrofolate Reductase Complexed with Nadph and Two Lipophilic Antifolates | 320 | 2002 |
| 1KMV | A.E.Klon, A.Heroux, L.J.Ross, V.Pathak, C.A.Johnson, J.R.Piper, D.W.Borhani | 677 | J.Mol.Biol. | Atomic Resolution Structures of Human Dihydrofolate Reductase Complexed with Nadph and Two Lipophilic Antifolates | 320 | 2002 |
| 1LY3 | V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, S.F.Queener, A.Gangjee | 1393 | Acta Crystallogr.,Sect.D | Analysis of Quinazoline and Pyrido[2,3-D]Pyrimidine N9-C10 Reversed-Bridge Antifolates in Complex with Nadp+ and Pneumocystis Carinii Dihydrofolate Reductase | 58 | 2002 |
| 1LY4 | V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, S.F.Queener, A.Gangjee | 1393 | Acta Crystallogr.,Sect.D | Analysis of Quinazoline and Pyrido[2,3-D]Pyrimidine N9-C10 Reversed-Bridge Antifolates in Complex with Nadp+ and Pneumocystis Carinii Dihydrofolate Reductase | 58 | 2002 |
| 1OHJ | V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, A.Rosowsky, R.L.Blakley | 13897 | Biochemistry | Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523. | 36 | 1997 |
| 1OHK | V.Cody, N.Galitsky, J.R.Luft, W.Pangborn, A.Rosowsky, R.L.Blakley | 13897 | Biochemistry | Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523. | 36 | 1997 |
| 1RA1 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RA2 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RA3 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RA8 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RA9 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RB2 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RB3 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RC4 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RD7 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RE7 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RF7 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RG7 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RH3 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX1 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX2 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX3 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX4 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX5 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX6 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX7 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX8 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1RX9 | M.R.Sawaya, J.Kraut | 586 | Biochemistry | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. | 36 | 1997 |
| 1TDR | J.O.Boles, K.Lewinski, M.G.Kunkle, M.Hatada, L.Lebioda, R.B.Dunlap, J.D.Odom | n/a | To be Published | Expression, Characterization, and Crystallographic Analysis of Telluromethionyl Dihydrofolate Reductase | n/a | n/a |
| 1VDR | U.Pieper, G.Kapadia, M.Mevarech, O.Herzberg | 75 | Structure | Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii. | 6 | 1998 |
| 1VIE | N.Narayana, D.A.Matthews, E.E.Howell, X.Nguyen-huu | 1018 | Nat Struct Biol | A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. | 2 | 1995 |
| 1VIF | N.Narayana, D.A.Matthews, E.E.Howell, X.Nguyen-huu | 1018 | Nat Struct Biol | A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. | 2 | 1995 |
| 2CD2 | V.Cody, N.Galitsky, D.Rak, J.R.Luft, W.Pangborn, S.F.Queener | 4303 | Biochemistry | Ligand-Induced Conformational Changes in the Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+ | 38 | 1999 |
| 2DHF | .2.Davies 2d, T.J.Delcamp, N.J.Prendergast, V.A.Ashford, J.H.Freisheim, J.Kraut | 9467 | Biochemistry | Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. | 29 | 1990 |
| 2DRC | M.S.Warren, K.A.Brown, M.F.Farnum, E.E.Howell, J.Kraut | 11092 | Biochemistry | Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis. | 30 | 1991 |
| 2GLT | K.Matsuda, K.Mizuguchi, T.Nishioka, H.Kato, N.Go, J.Oda | 1083 | Protein Eng | Crystal structure of glutathione synthetase at optimal pH: domain architecture and structural similarity with other proteins. | 9 | 1996 |
| 3CD2 | V.Cody, N.Galitsky, D.Rak, J.R.Luft, W.Pangborn, S.F.Queener | 4303 | Biochemistry | Ligand-Induced Conformational Changes in the Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+ | 38 | 1999 |
| 3DFR | J.T.Bolin, D.J.Filman, D.A.Matthews, R.C.Hamlin, J.Kraut | 13650 | J Biol Chem | Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. | 257 | 1982 |
| 3DRC | M.S.Warren, K.A.Brown, M.F.Farnum, E.E.Howell, J.Kraut | 11092 | Biochemistry | Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis. | 30 | 1991 |
| 4CD2 | V.Cody, N.Galitsky, D.Rak, J.R.Luft, W.Pangborn, S.F.Queener | 4303 | Biochemistry | Ligand-Induced Conformational Changes in the Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+ | 38 | 1999 |
| 4DFR | J.T.Bolin, D.J.Filman, D.A.Matthews, R.C.Hamlin, J.Kraut | 13650 | J Biol Chem | Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. | 257 | 1982 |
| 5DFR | C.Bystroff, J.Kraut | 2227 | Biochemistry | Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding. | 30 | 1991 |
| 6DFR | C.Bystroff, S.J.Oatley, J.Kraut | 3263 | Biochemistry | Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state. | 29 | 1990 |
| 7DFR | C.Bystroff, S.J.Oatley, J.Kraut | 3263 | Biochemistry | Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state. | 29 | 1990 |
| 8DFR | J.F.Davies /II, D.A.Matthews, S.J.Oatley, B.T.Kaufman, N.-H.Xuong, J.Kraut | n/a | To be Published | Refined Crystal Structures of Chicken Liver Dihydrofolate Reductase. 3 Angstroms Apo-Enzyme and 1.7 Angstroms /Nadph Holo-Enzyme Complex | n/a | n/a |
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