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Reverse Transcriptase
| PDB ID | Authors | First Page | Medline Link | Journal Name | Title | Volume No | Publication Year |
| 1AKJ | G.F.Gao, J.Tormo, U.C.Gerth, J.R.Wyer, A.J.McMichael, D.I.Stuart, J.I.Bell, E.Y.Jones, B.K.Jakobsen | 630 | 9177355 | Nature | Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. | 387 | 1997 |
| 1BQM | Y.Hsiou, K.Das, J.Ding, A.D.Clark Jr., J.P.Kleim, M.Rosner, I.Winkler, G.Riess, S.H.Hughes, E.Arnold | 313 | 9813120 | J Mol Biol | Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. | 284 | 1998 |
| 1BQN | Y.Hsiou, K.Das, J.Ding, A.D.Clark Jr., J.P.Kleim, M.Rosner, I.Winkler, G.Riess, S.H.Hughes, E.Arnold | 313 | 9813120 | J Mol Biol | Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. | 284 | 1998 |
| 1BVJ | E.V.Puglisi, J.D.Puglisi | 1033 | 9846871 | Nat Struct Biol | HIV-1 A-rich RNA loop mimics the tRNA anticodon structure. | 5 | 1998 |
| 1BYX | T.Szyperski, M.Goette, M.Billeter, E.Perola, L.Cellai, H.Heumann, K.Wuethrich | 343 | ( 1BYX ) | J.Biomol.NMR | NMR Structure of the Chimeric Hybrid Duplex R(Gcaguggc).R(Gcca)D(Ctgc) Comprising the tRNA-DNA Junction Formed During Initiation of HIV-1 Reverse Transcription | 13 | 1999 |
| 1C0T | J.Ren, R.M.Esnouf, A.L.Hopkins, D.I.Stuart, D.K.Stammers | 3845 | ( 1C0T ) | J.Med.Chem. | Crystallographic Analysis of the Binding Modes of Thiazoloisoindolinone Non- Nucleoside Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modelling Studies | 42 | 1999 |
| 1C0U | J.Ren, R.M.Esnouf, A.L.Hopkins, D.I.Stuart, D.K.Stammers | 3845 | ( 1C0U ) | J.Med.Chem. | Crystallographic Analysis of the Binding Modes of Thiazoloisoindolinone Non- Nucleoside Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modelling Studies | 42 | 1999 |
| 1C1B | A.L.Hopkins, J.Ren, H.Tanaka, B.Baba, M.Okamato, D.I.Stuart, D.K.Stammers | 4500 | ( 1C1B ) | J.Med.Chem. | Design of Mkc-442 (Emivirine) Analogues with Improved Activity Against Drug Resistant HIV Mutants | 42 | 1999 |
| 1C1C | A.L.Hopkins, J.Ren, H.Tanaka, M.Baba, M.Okamato, D.I.Stuart, D.K.Stammers | 4500 | ( 1C1C ) | J.Med.Chem. | Design of Mkc-442 (Emivirine) Analogues with Improved Activity Against Drug-Resistant HIV Mutants | 42 | 1999 |
| 1D0E | S.Najmudin, M.L.Cote, D.Sun, S.Yohannan, S.P.Montano, J.Gu, M.M.Georgiadis | 613 | ( 1D0E ) | J.Mol.Biol. | Crystal Structures of an N-Terminal Fragment from Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications for Template-Primer Binding to the Fingers Domain | 296 | 2000 |
| 1D1U | M.L.Cote, S.J.Yohannan, M.M.Georgiadis | 1120 | ( 1D1U ) | Acta Crystallogr., Sect.D | Use of an N-Terminal Fragment from Moloney Murine Leukemia Virus Reverse Transcriptase to Facilitate Crystallization and Analysis of a Pseudo-16-mer DNA Molecule Containing G-A Mispairs | 56 | 2000 |
| 1DLO | Y.Hsiou, J.Ding, K.Das, A.D.Clark Jr., S.H.Hughes, E.Arnold | 853 | 8805568 | Structure | Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. | 4 | 1996 |
| 1DTQ | J.Ren, J.Diprose, J.Warren, R.M.Esnouf, L.E.Bird, S.Ikemizu, M.Slater, J.Milton, J.Balzarini, D.I.Stuart, D.K.Stammers | 5633 | ( 1DTQ ) | J.Biol.Chem. | Phenylethylthiazolylthiourea (Pett) Non-Nucleoside Inhibitors of HIV-1 and HIV- 2 Reverse Transcriptases. Structural and Biochemical Analyses | 275 | 2000 |
| 1DTT | J.Ren, J.Diprose, J.Warren, R.M.Esnouf, L.E.Bird, S.Ikemizu, M.Slater, J.Milton, J.Balzarini, D.I.Stuart, D.K.Stammers | 5633 | ( 1DTT ) | J.Biol.Chem. | Phenylethylthiazolylthiourea (Pett) Non-Nucleoside Inhibitors of HIV-1 and HIV- 2 Reverse Transcriptases. Structural and Biochemical Analyses | 275 | 2000 |
| 1EET | M.Hogberg, C.Sahlberg, P.Engelhardt, R.Noreen, J.Kangasmetsa, N.G.Johansson, B.Oberg, L.Vrang, H.Zhang, B.L.Sahlberg, T.Unge, S.Lovgren, K.Fridborg, K.Backbro | 304 | ( 1EET ) | J.Med.Chem. | Urea-Pett Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 3. Synthesis and Further Structure-Activity Relationship Studies of Pett Analogues | 43 | 2000 |
| 1EP4 | J.Ren, C.Nichols, L.E.Bird, T.Fujiwara, H.Suginoto, D.I.Stuart, D.K.Stammers | 14316 | ( 1EP4 ) | J.Biol.Chem. | Binding of the Second Generation Non-Nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding | 275 | 2000 |
| 1F3F | P.Meyer, B.Schneider, S.Sarfati, D.Deville-Bonne, C.Guerreiro, J.Boretto, J.Janin, M.Veron, B.Canard | 3520 | ( 1F3F ) | Embo J. | Structural Basis for Activation of Alpha-Boranophosphate Nucleotide Analogues Targeting Drug-Resistant Reverse Transcriptase | 19 | 2000 |
| 1F6T | P.Meyer, B.Schneider, S.Sarfati, D.Deville-Bonne, C.Guerreiro, J.Boretto, J.Janin, M.Veron, B.Canard | 3520 | ( 1F6T ) | Embo J. | Structural Basis for Activation of Alpha-Boranophosphate Nucleotide Analogues Targeting Drug-Resistant Reverse Transcriptase | 19 | 2000 |
| 1FIX | N.C.Horton, B.C.Finzel | 521 | 8969302 | J Mol Biol | The structure of an RNA/DNA hybrid: a substrate of the ribonuclease activity of HIV-1 reverse transcriptase. | 264 | 1996 |
| 1FK9 | J.Ren, J.Milton, K.L.Weaver, S.A.Short, D.I.Stuart, D.K.Stammers | 1089 | ( 1FK9 ) | Structure | Structural Basis for the Resilience of Efavirenz (Dmp-266) to Drug Resistant Mutations in HIV-1 Reverse Transcriptase | 8 | 2000 |
| 1FKO | J.Ren, J.Milton, K.L.Weaver, S.A.Short, D.I.Stuart, D.K.Stammers | 1089 | ( 1FKO ) | Structure | Structural Basis for the Resilience of Efavirenz (Dmp-266) to Drug Resistant Mutations in HIV-1 Reverse Transcriptase | 8 | 2000 |
| 1FKP | J.Ren, J.Milton, K.L.Weaver, S.A.Short, D.I.Stuart, D.K.Stammers | 1089 | ( 1FKP ) | Structure | Structural Basis for the Resilience of Efavirenz (Dmp-266) to Drug Resistant Mutations in HIV-1 Reverse Transcriptase | 8 | 2000 |
| 1GOA | K.Ishikawa, H.Nakamura, K.Morikawa, S.Kimura, S.Kanaya | 7136 | 8393706 | Biochemistry | Cooperative stabilization of Escherichia coli ribonuclease HI by insertion of Gly-80b and Gly-77-->Ala substitution. | 32 | 1993 |
| 1GOB | K.Ishikawa, H.Nakamura, K.Morikawa, S.Kimura, S.Kanaya | 7136 | 8393706 | Biochemistry | Cooperative stabilization of Escherichia coli ribonuclease HI by insertion of Gly-80b and Gly-77-->Ala substitution. | 32 | 1993 |
| 1GOC | K.Ishikawa, H.Nakamura, K.Morikawa, S.Kimura, S.Kanaya | 7136 | 8393706 | Biochemistry | Cooperative stabilization of Escherichia coli ribonuclease HI by insertion of Gly-80b and Gly-77-->Ala substitution. | 32 | 1993 |
| 1GTC | O.Y.u.Fedoroff, M.Salazar, B.R.Reid | 11070 | 8780509 | Biochemistry | Structural variation among retroviral primer-DNA junctions: solution structure of the HIV-1 (-)-strand Okazaki fragment r(gcca)d(CTGC).d(GCAGTGGC). | 35 | 1996 |
| 1GZP | S.D.Gadola, N.R.Zaccai, K.Harlos, D.Shepherd, J.C.Castro-Palomino, G.Ritter, R.R.Schmidt, E.Y.Jones, V.Cerundolo | 721 | ( 1GZP ) | Nat.Immunol. | Structure of Human Cd1B with Bound Ligands at 2.3 A, a Maze for Alkyl Chains | 3 | 2002 |
| 1GZQ | S.D.Gadola, N.R.Zaccai, K.Harlos, D.Shepherd, J.C.Castro-Palomino, G.Ritter, R.R.Schmidt, E.Y.Jones, V.Cerundolo | 721 | ( 1GZQ ) | Nat.Immunol. | Structure of Human Cd1B with Bound Ligands at 2.3 A, a Maze for Alkyl Chains | 3 | 2002 |
| 1HAR | T.Unge, S.Knight, R.Bhikhabhai, S.Lovgren, Z.Dauter, K.Wilson, B.Strandberg | 953 | 7532533 | Structure | 2.2 A resolution structure of the amino-terminal half of HIV-1 reverse transcriptase (fingers and palm subdomains). | 2 | 1994 |
| 1HHJ | D.R.Madden, D.N.Garboczi, D.C.Wiley | 693 | 7694806 | Cell | The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. | 75 | 1993 |
| 1HMV | D.W.Rodgers, S.J.Gamblin, B.A.Harris, S.Ray, J.S.Culp, B.Hellmig, D.J.Woolf, C.Debouck, S.C.Harrison | 1222 | 7532306 | Proc Natl Acad Sci U S A | The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1. | 92 | 1995 |
| 1HNI | J.Ding, K.Das, C.Tantillo, W.Zhang, A.D.Clark Jr., S.Jessen, X.Lu, Y.Hsiou, A.Jacobo-Molina, K.Andries, et al. | 365 | 7542140 | Structure | Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution. | 3 | 1995 |
| 1HNV | J.Ding, K.Das, H.Moereels, L.Koymans, K.Andries, P.A.Janssen, S.H.Hughes, E.Arnold | 407 | 7545077 | Nat Struct Biol | Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. | 2 | 1995 |
| 1HPZ | Y.Hsiou, J.Ding, K.Das, A.D.Clark, P.L.Boyer, P.Lewi, P.A.J.Janssen, J.-P.Kleim, M.Roesner, S.H.Hughes, E.Arnold | 437 | ( 1HPZ ) | J.Mol.Biol. | The Lys103Asn Mutation of HIV-1 RT: A Novel Mechanism of Drug Resistance | 309 | 2001 |
| 1HQE | Y.Hsiou, J.Ding, K.Das, A.D.Clark, P.L.Boyer, P.Lewi, P.A.J.Janssen, J.-P.Kleim, M.Roesner, S.H.Hughes, E.Arnold | 437 | ( 1HQE ) | J.Mol.Biol. | The Lys103Asn Mutation of HIV-1 RT: A Novel Mechanism of Drug Resistance | 309 | 2001 |
| 1HQU | Y.Hsiou, J.Ding, K.Das, A.D.Clark, P.L.Boyer, P.Lewi, P.A.J.Janssen, J.-P.Kleim, M.Roesner, S.H.Hughes, E.Arnold | 437 | ( 1HQU ) | J.Mol.Biol. | The Lys103Asn Mutation of HIV-1 RT: A Novel Mechanism of Drug Resistance | 309 | 2001 |
| 1HRH | .2.Davies 2d, Z.Hostomska, Z.Hostomsky, S.R.Jordan, D.A.Matthews | 88 | 1707186 | Science | Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. | 252 | 1991 |
| 1HVU | J.Jaeger, T.Restle, T.A.Steitz | 4535 | 9687519 | EMBO J | The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor. | 17 | 1998 |
| 1HYS | S.G.Sarafianos, K.Das, C.Tantillo, A.D.Clark Jr., J.Ding, J.Whitcomb, P.L.Boyer, S.H.Hughes, E.Arnold | 1449 | ( 1HYS ) | Embo J. | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with a Polypurine Tract RNA:DNA | 20 | 2001 |
| 1I1F | T.J.Kirksey, R.R.Pogue-Caley, J.A.Frelinger, E.J.Collins | 37259 | ( 1I1F ) | J.Biol.Chem. | The Structural Basis for the Increased Immunogenicity of Two HIV-Reverse Transcriptase Peptide Variant/Class I Major Histocompatibility Complexes | 274 | 1999 |
| 1I1Y | T.J.Kirksey, R.R.Pogue-Caley, J.A.Frelinger, E.J.Collins | 37259 | ( 1I1Y ) | J.Biol.Chem. | The Structural Basis for the Increased Immunogenicity of Two HIV-Reverse Transcriptase Peptide Variant/Class I Major Histocompatibility Complexes | 274 | 1999 |
| 1I6J | M.L.Cote, M.M.Georgiadis | 1238 | ( 1I6J ) | Acta Crystallogr., Sect.D | Structure of a Pseudo-16-mer DNA with Stacked Guanines and Two G-A Mispairs Complexed with the N-Terminal Fragment of Moloney Murine Leukemia Virus Reverse Transcriptase | 57 | 2001 |
| 1IKV | J.Lindberg, S.Sigurdsson, S.Lowgren, H.O.Andersson, C.Sahlberg, R.Noreen, K.Fridborg, H.Zhang, T.Unge | 1670 | ( 1IKV ) | Eur.J.Biochem. | Structural Basis for the Inhibitory Efficacy of Efavirenz (Dmp-266), Msc194 and Pnu142721 Towards the HIV-1 RT K103N Mutant | 269 | 2002 |
| 1IKW | J.Lindberg, S.Sigurdsson, S.Lowgren, H.O.Andersson, C.Sahlberg, R.Noreen, K.Fridborg, H.Zhang, T.Unge | 1670 | ( 1IKW ) | Eur.J.Biochem. | Structural Basis for the Inhibitory Efficacy of Efavirenz (Dmp-266), Msc194 and Pnu142721 Towards the HIV-1 RT K103N Mutant | 269 | 2002 |
| 1IKX | J.Lindberg, S.Sigurdsson, S.Lowgren, H.O.Andersson, C.Sahlberg, R.Noreen, K.Fridborg, H.Zhang, T.Unge | 1670 | ( 1IKX ) | Eur.J.Biochem. | Structural Basis for the Inhibitory Efficacy of Efavirenz (Dmp-266), Msc194 and Pnu142721 Towards the HIV-1 RT K103N Mutant | 269 | 2002 |
| 1IKY | J.Lindberg, S.Sigurdsson, S.Lowgren, H.O.Andersson, C.Sahlberg, R.Noreen, K.Fridborg, H.Zhang, T.Unge | 1670 | ( 1IKY ) | Eur.J.Biochem. | Structural Basis for the Inhibitory Efficacy of Efavirenz (Dmp-266), Msc194 and Pnu142721 Towards the HIV-1 RT K103N Mutant | 269 | 2002 |
| 1J5O | S.G.Sarafianos, K.Das, A.D.Clark Jr., J.Ding, P.L.Boyer, S.H.Hughes, E.Arnold | 10027 | ( 1J5O ) | Proc.Nat.Acad.Sci.USA | Lamivudine (3Tc) Resistance in HIV-1 Reverse Transcriptase Involves Steric Hindrance with Beta-Branched Amino Acids | 96 | 1999 |
| 1JKH | J.Ren, C.Nichols, L.Bird, P.Chamberlain, K.Weaver, S.Short, D.I.Stuart, D.K.Stammers | 795 | ( 1JKH ) | J.Mol.Biol. | Structural Mechanisms of Drug Resistance for Mutations at Codons 181 and 188 in HIV-1 Reverse Transcriptase and the Improved Resilience of Second Generation Non-Nucleoside Inhibitors | 312 | 2001 |
| 1JLA | J.Ren, C.Nichols, L.Bird, P.Chamberlain, K.Weaver, S.Short, D.I.Stuart, D.K.Stammers | 795 | ( 1JLA ) | J.Mol.Biol. | Structural Mechanisms of Drug Resistance for Mutations at Codons 181 and 188 in HIV-1 Reverse Transcriptase and the Improved Resilience of Second Generation Non-Nucleoside Inhibitors | 312 | 2001 |
| 1JLB | J.Ren, C.Nichols, L.Bird, P.Chamberlain, K.Weaver, S.Short, D.I.Stuart, D.K.Stammers | 795 | ( 1JLB ) | J.Mol.Biol. | Structural Mechanisms of Drug Resistance for Mutations at Codons 181 and 188 in HIV-1 Reverse Transcriptase and the Improved Resilience of Second Generation Non-Nucleoside Inhibitors | 312 | 2001 |
| 1JLC | J.Ren, C.Nichols, L.Bird, P.Chamberlain, K.Weaver, S.Short, D.I.Stuart, D.K.Stammers | 795 | ( 1JLC ) | J.Mol.Biol. | Structural Mechanisms of Drug Resistance for Mutations at Codons 181 and 188 in HIV-1 Reverse Transcriptase and the Improved Resilience of Second Generation Non-Nucleoside Inhibitors | 312 | 2001 |
| 1JLE | J.Ren, C.Nichols, L.Bird, P.Chamberlain, K.Weaver, S.Short, D.I.Stuart, D.K.Stammers | 795 | ( 1JLE ) | J.Mol.Biol. | Structural Mechanisms of Drug Resistance for Mutations at Codons 181 and 188 in HIV-1 Reverse Transcriptase and the Improved Resilience of Second Generation Non-Nucleoside Inhibitors | 312 | 2001 |
| 1JLF | J.Ren, C.Nichols, L.Bird, P.Chamberlain, K.Weaver, S.Short, D.I.Stuart, D.K.Stammers | 795 | ( 1JLF ) | J.Mol.Biol. | Structural Mechanisms of Drug Resistance for Mutations at Codons 181 and 188 in HIV-1 Reverse Transcriptase and the Improved Resilience of Second Generation Non-Nucleoside Inhibitors | 312 | 2001 |
| 1JLG | J.Ren, C.Nichols, L.Bird, P.Chamberlain, K.Weaver, S.Short, D.I.Stuart, D.K.Stammers | 795 | ( 1JLG ) | J.Mol.Biol. | Structural Mechanisms of Drug Resistance for Mutations at Codons 181 and 188 in HIV-1 Reverse Transcriptase and the Improved Resilience of Second Generation Non-Nucleoside Inhibitors | 312 | 2001 |
| 1JLQ | J.H.Chan, J.S.Hong, R.N.Hunter III, G.F.Orr, J.R.Cowan, D.B.Sherman, S.M.Sparks, B.E.Reitter, C.W.Andrews III, R.J.Hazen, M.St Clair, L.R.Boone, R.G.Ferris, K.L.Creech, G.B.Roberts, S.A.Short, K.Weaver, R.J.Ott, J.Ren, A.Hopkins, D.I.Stuart, D.K.Stammers | 1866 | ( 1JLQ ) | J.Med.Chem. | 2-Amino-6-Arylsulfonylbenzonitriles as Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1 | 44 | 2001 |
| 1KJG | M.Prabu-Jeyabalan, E.A.Nalivaika, C.A.Schiffer | 369 | ( 1KJG ) | Structure | Substrate Shape Determines Specificity of Recognition for HIV-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes | 10 | 2002 |
| 1KLM | R.M.Esnouf, J.Ren, A.L.Hopkins, C.K.Ross, E.Y.Jones, D.K.Stammers, D.I.Stuart | 3984 | 9108091 | Proc Natl Acad Sci U S A | Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. | 94 | 1997 |
| 1LAV | K.Ishikawa, H.Nakamura, K.Morikawa, S.Kanaya | 6171 | ( 1LAV ) | Biochemistry | Stabilization of Escherichia Coli Ribonuclease Hi by Cavity-Filling Mutations within a Hydrophobic Core | 32 | 1993 |
| 1LAW | K.Ishikawa, H.Nakamura, K.Morikawa, S.Kanaya | 6171 | ( 1LAW ) | Biochemistry | Stabilization of Escherichia Coli Ribonuclease Hi by Cavity-Filling Mutations within a Hydrophobic Core | 32 | 1993 |
| 1MML | M.M.Georgiadis, S.M.Jessen, C.M.Ogata, A.Telesnitsky, S.P.Goff, W.A.Hendrickson | 879 | 8535782 | Structure | Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase. | 3 | 1995 |
| 1OKA | M.Salazar, O.Y.Fedoroff, B.R.Reid | 8126 | 8679564 | Biochemistry | Structure of chimeric duplex junctions: solution conformation of the retroviral Okazaki-like fragment r(ccca)d(AATGA).d(TCATTTGGG) from Moloney murine leukemia virus. | 35 | 1996 |
| 1PLS | H.S.Yoon, P.J.Hajduk, A.M.Petros, E.T.Olejniczak, R.P.Meadows, S.W.Fesik | 672 | 8208296 | Nature | Solution structure of a pleckstrin-homology domain. | 369 | 1994 |
| 1QAI | S.Najmudin, M.Cote, D.Sun, S.Yohannan, S.P.Montano, J.Gu, M.M.Georgiadis | 613 | ( 1QAI ) | J.Mol.Biol. | Crystal Structures of an N-Terminal Fragment from Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications for Template-Primer Binding to the Fingers Domain | 296 | 2000 |
| 1QAJ | S.Najmudin, M.L.Cote, D.Sun, S.Yohannan, S.P.Montano, J.Gu, M.M.Georgiadis | 613 | ( 1QAJ ) | J.Mol.Biol. | Crystal Structures of an N-Terminal Fragment from Moloney Murine Leukemia Virus Reverse Transcriptase Complexed with Nucleic Acid: Functional Implications for Template-Primer Binding to the Fingers Domain | 296 | 2000 |
| 1QE1 | S.G.Sarafianos, K.Das, J.Ding, S.H.Hughes, E.Arnold | 10027 | ( 1QE1 ) | Proc.Nat.Acad.Sci.USA | 3Tc (Lamivudine) Resistance in HIV Reverse Transcriptase Involves Steric Hindrance with Beta-Branched Amino Acids | 96 | 1999 |
| 1RBR | K.Ishikawa, S.Kimura, S.Kanaya, K.Morikawa, H.Nakamura | 85 | 8381958 | Protein Eng | Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability. | 6 | 1993 |
| 1RBS | K.Ishikawa, S.Kimura, S.Kanaya, K.Morikawa, H.Nakamura | 85 | 8381958 | Protein Eng | Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability. | 6 | 1993 |
| 1RBT | K.Ishikawa, S.Kimura, S.Kanaya, K.Morikawa, H.Nakamura | 85 | 8381958 | Protein Eng | Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability. | 6 | 1993 |
| 1RBU | K.Ishikawa, S.Kimura, S.Kanaya, K.Morikawa, H.Nakamura | 85 | 8381958 | Protein Eng | Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability. | 6 | 1993 |
| 1RBV | K.Ishikawa, S.Kimura, S.Kanaya, K.Morikawa, H.Nakamura | 85 | 8381958 | Protein Eng | Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability. | 6 | 1993 |
| 1RDH | D.Chattopadhyay, B.C.Finzel, S.H.Munson, D.B.Evans, S.K.Sharma, N.A.Strakalaitis, D.P.Brunner, F.M.Eckenrode, Z.Dauter, C.Betzel, H.M.Einspahr | 423 | ( 1RDH ) | Acta Crystallogr D Biol Crystallogr | CRYSTALLOGRAPHIC ANALYSES OF AN ACTIVE HIV-1 RIBONUCLEASE H DOMAIN SHOW STRUCTURAL FEATURES THAT DISTINGUISH IT FROM THE INACTIVE FORM. | 49 | 1993 |
| 1REV | J.Ren, R.Esnouf, A.Hopkins, C.Ross, Y.Jones, D.Stammers, D.Stuart | 915 | 8535785 | Structure | The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design. | 3 | 1995 |
| 1RT1 | A.L.Hopkins, J.Ren, R.M.Esnouf, B.E.Willcox, E.Y.Jones, C.Ross, T.Miyasaka, R.T.Walker, H.Tanaka, D.K.Stammers, D.I.Stuart | 1589 | 8648598 | J Med Chem | Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. | 39 | 1996 |
| 1RT2 | A.L.Hopkins, J.Ren, R.M.Esnouf, B.E.Willcox, E.Y.Jones, C.Ross, T.Miyasaka, R.T.Walker, H.Tanaka, D.K.Stammers, D.I.Stuart | 1589 | 8648598 | J Med Chem | Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. | 39 | 1996 |
| 1RT3 | J.Ren, R.M.Esnouf, A.L.Hopkins, E.Y.Jones, I.Kirby, J.Keeling, C.K.Ross, B.A.Larder, D.I.Stuart, D.K.Stammers | 9518 | 9689112 | Proc Natl Acad Sci U S A | 3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. | 95 | 1998 |
| 1RT4 | J.Ren, R.M.Esnouf, A.L.Hopkins, J.Warren, J.Balzarini, D.I.Stuart, D.K.Stammers | 14394 | 9772165 | Biochemistry | Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. | 37 | 1998 |
| 1RT5 | J.Ren, R.M.Esnouf, A.L.Hopkins, J.Warren, J.Balzarini, D.I.Stuart, D.K.Stammers | 14394 | ( 1RT5 ) | Biochemistry | Crystal Structures of HIV-1 Reverse Transcriptase in Complex with Carboxanilide Derivatives | 37 | 1998 |
| 1RT6 | J.Ren, R.M.Esnouf, A.L.Hopkins, J.Warren, J.Balzarini, D.I.Stuart, D.K.Stammers | 14394 | ( 1RT6 ) | Biochemistry | Crystal Structures of HIV-1 Reverse Transcriptase in Complex with Carboxanilide Derivatives | 37 | 1998 |
| 1RT7 | J.Ren, R.M.Esnouf, A.L.Hopkins, J.Warren, J.Balzarini, D.I.Stuart, D.K.Stammers | 14394 | ( 1RT7 ) | Biochemistry | Crystal Structures of HIV-1 Reverse Transcriptase in Complex with Carboxanilide Derivatives | 37 | 1998 |
| 1RTD | H.Huang, R.Chopra, G.L.Verdine, S.C.Harrison | 1669 | 9831551 | Science | Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. | 282 | 1998 |
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