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Penicillin-binding Protein
Exploring the Structure
The PDB entry 1hvb shows a penicillin-binding protein in action. The enzyme is a D-alanyl-D-alanine carboxypeptidase/transpeptidase that creates a crosslink between two chains in the peptidoglycan net. The structure contains a molecule specially designed by researchers to capture a snapshot of the process of crosslinking. Cephalosporin, a drug similar to penicillin, is bound directly to the serine in the active site. The drug is in the position normally occupied by one of the strands to be crosslinked, as indicated by the transparent dots that extend to the left. A little peptide has been attached to this drug in the position normally occupied by the other strand in the crosslink. This structure shows how the complex might look just after the crosslink is made.This illustration was created with RasMol. You can create similar pictures by clicking on the accession codes above and choosing one of the options under View Structure.
A list of all penicillin-binding proteins in the PDB as of May 2002 is available here. For more information on penicillin-binding proteins, click here.
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Last changed by: A.Honegger,