 |
Inhaltsübersicht | Nanomaschinen | Moleküle | Programme | Kurse | Fun | Links |
 |
| > |
Anthrax Toxin
Exploring the Structure
The edema factor is activated once it gets inside cells by binding to calmodulin, a protein that is very common in our cells. The factor is shown before activation on the left in PDB entry 1k8t and after activation on the right in PDB entry 1jky. Notice how calmodulin, shown in yellow, opens up the edema factor, making the active site more available. It also shifts the placement of two key loops, shown in purple. In the unactivated form, one of these loops hangs down away from the active site and the other is disordered, as indicated by the purple dots on its right side. In the activated form, these two loops hold ATP tightly, forming part of the active site that will convert it to cyclic AMP.This illustration was created with RasMol. You can create similar illustrations by clicking on the accession codes above and picking one of the options under View Structure.
A list of all anthrax toxin structures in the PDB as of April, 2002, is available here. For more information on anthrax toxin, click here.
Next: Interaktive 3D-Animation
Previous: Edema Factor and Lethal Factor
Last changed by: A.Honegger,