The different numbering schemes for immunoglobulin variable domains (Kabat: Kabat et al., 1991; Chothia: Chothia & Lesk, 1987; Al-Lazikani et al., 1997; IMGT: Lefranc, 1997; AHo: this study) have been aligned. Boxes with dark gray background indicate the residues whose Ca-coordinates were used for the least squares alignment of the representative structures of each type of variable domain. Pink background indicates the placement of insertions/deletions implied by the numbering scheme. White dots on black background indicate additional gaps introduced to bring the different numbering schemes into structural alignment. White background indicates the position of the complementarity determining regions. In the AHo numbering scheme, gaps are centered on the positions indicated in yellow.

Alignment of reference sequences Deviation from average structure Standard Header