Sequences representing the different types of immunoglobulin variable domains (immunoglobulin VH, Vk and Vl, T-cell receptor Va, Vb and Vd) were aligned as to minimize the average deviation from the average structure. The amino acids are color coded according to residue type: aromatic residues (Tyr, Phe, Trp) orange, hydrophobic residues (Leu, Ile, Val, Met, Cys, Pro, Ala) yellow, uncharged hydrophilic residues (Ser, Thr, Gln, Asn, Gly) green, acidic residues (Asp, Glu) red, basic residues (Arg, Lys, His) blue.

Numbering Schemes Deviation from average structure Standard Header