Average deviation from the mean Ca-position: Individual domains were excised from the corresponding PDB files and aligned by a least squares fit of the Ca-positions of the core residues (3-7, 20-24, 41-47, 51-57, 78-82, 89-93, 102-108 and 138-144) to the corresponding Ca-positions of a reference structure (Vk domain of 1F58, Stanfield et al., 1999). The mean Ca coordinates for each position in the alignment were calculated and the deviation of each residue in each structure from the average structure calculated and color-coded in the corresponding sequence alignment (white: rms deviation < 0.5 Å, yellow: 0.5-1 Å, yellow-orange: 1-1.5 Å, orange 1.5-2 Å, orange-red 2-4 Å, red >4 Å).

Numbering SchemesAlignment of reference sequences Standard Header