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Topoisomerase
Exploring the Structure
PDB entry 1a31 captures a class I topoisomerase in the middle of relaxing a strand of DNA. A tyrosine has broken one strand of the DNA, and formed a covalent bond to the phosphate group at the end of the broken strand. After the strands have spun a few times to release any tension, the enzyme will reform the broken bond in the DNA backbone.This picture was created with RasMol. You can create similar pictures by clicking on the accession codes here and picking one of the options under Display Molecule.
A list of Topoisomerase related entries in the PDB as determined by a keyword search on December 29, 2005 is available here. For more information on Topoisomerase, click here.
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Last changed by: A.Honegger,