Human V lambda Germline Sequences (VBase)

                                            111111111122222222 222222 22333333333344444444445        555555555666666666  677777777778888888888999999999999
Kabat V lambda                     123456789012345678901234567 777777 89012345678901234567890        123456789012345678  901234567890123456789012345555555
                                                               abcd4f                                                                               abcdef
CDR (x)                            ....:....|....:....|...xxxxxxxxxxxxxxxxxxx..:....|....:..xxxxxxxxxxxxxxx..:....|....:....|....:....|....:.xxxxxxxxxxxxx
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                                            11111111112222222222333333333344444444445555555555666666666677777777778888888888999999999900000000001111111111
AH0                                12345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789
                                   ....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....
VBase_VL1_1    13-7(A)   1a         QSVLTQP.PSVSEAPRQRVTISCSGSS.SNIGN.....NAVNWYQQLPGKAPKLLIYY........DDLLPSGVSDRFSGSKSG..TSASLAISGLQSEDEADYYCAAWDDSLNG...
VBase_VL1_2    14-7(A)   1e         QSVLTQP.PSVSGAPGQRVTISCTGSS.SNIGAG....YDVHWYQQLPGTAPKLLIYG........NSNRPSGVPDRFSGSKSG..TSASLAITGLQAEDEADYYCQSYDSSLSG...
VBase_VL1_3    13-7(A)   1c         QSVLTQP.PSASGTPGQRVTISCSGSS.SNIGS.....NTVNWYQQLPGTAPKLLIYS........NNQRPSGVPDRFSGSKSG..TSASLAISGLQSEDEADYYCAAWDDSLNG...
VBase_VL1_4    13-7(A)   1g         QSVLTQP.PSASGTPGQRVTISCSGSS.SNIGS.....NYVYWYQQLPGTAPKLLIYR........NNQRPSGVPDRFSGSKSG..TSASLAISGLRSEDEADYYCAAWDDSLSG...
VBase_VL1_5    13-7(A)   1b         QSVLTQP.PSVSAAPGQKVTISCSGSS.SNIGN.....NYVSWYQQLPGTAPKLLIYD........NNKRPSGIPDRFSGSKSG..TSATLGITGLQTGDEADYYCGTWDSSLSA...

VBase_VL2_1    14-7(A)   2c         QSALTQP.PSASGSPGQSVTISCTGTS.SDVGGY....NYVSWYQQHPGKAPKLMIYE........VSKRPSGVPDRFSGSKSG..NTASLTVSGLQAEDEADYYCSSYAGSNNF...
VBase_VL2_2    14-7(A)   2e         QSALTQP.RSVSGSPGQSVTISCTGTS.SDVGGY....NYVSWYQQHPGKAPKLMIYD........VSKRPSGVPDRFSGSKSG..NTASLTISGLQAEDEADYYCCSYAGSYTF...
VBase_VL2_3    14-7(A)   2a2        QSALTQP.ASVSGSPGQSITISCTGTS.SDVGGY....NYVSWYQQHPGKAPKLMIYE........VSNRPSGVSNRFSGSKSG..NTASLTISGLQAEDEADYYCSSYTSSSTL...
VBase_VL2_4    14-7(A)   2d         QSALTQP.PSVSGSPGQSVTISCTGTS.SDVGSY....NRVSWYQQPPGTAPKLMIYE........VSNRPSGVPDRFSGSKSG..NTASLTISGLQAEDEADYYCSLYTSSSTF...
VBase_VL2_5    14-7(A)   2b2        QSALTQP.ASVSGSPGQSITISCTGTS.SDVGSY....NLVSWYQQHPGKAPKLMIYE........VSKRPSGVSNRFSGSKSG..NTASLTISGLQAEDEADYYCCSYAGSSTF...

VBase_VL3_1    11-7      3r         SYELTQP.PSVSVSPGQTASITCSGD...KLGD.....KYACWYQQKPGQSPVLVIYQ........DSKRPSGIPERFSGSNSG..NTATLTISGTQAMDEADYYCQAWDSSTA....
VBase_VL3_2    11-7      3j         SYELTQP.LSVSVALGQTARITCGGN...NIGS.....KNVHWYQQKPGQAPVLVIYR........DSNRPSGIPERFSGSNSG..NTATLTISRAQAGDEADYYCQVWDSSTA....
VBase_VL3_3    11-7      3p         SYELTQP.PSVSVSPGQTARITCSGD...ALPK.....KYAYWYQQKSGQAPVLVIYE........DSKRPSGIPERFSGSSSG..TMATLTISGAQVEDEADYYCYSTDSSGNH...
VBase_VL3_4    11-7      3a         SYELTQP.PSVSVSLGQMARITCSGE...ALPK.....KYAYWYQQKPGQFPVLVIYK........DSERPSGIPERFSGSSSG..TIVTLTISGVQAEDEADYYCLSADSSGTY...
VBase_VL3_5    11-7      3l         SSELTQD.PAVSVALGQTVRITCQGD...SLRS.....YYASWYQQKPGQAPVLVIYG........KNNRPSGIPDRFSGSSSG..NTASLTITGAQAEDEADYYCNSRDSSGNH...
VBase_VL3_6    11-7      3h         SYVLTQP.PSVSVAPGKTARITCGGN...NIGS.....KSVHWYQQKPGQAPVLVIYY........DSDRPSGIPERFSGSNSG..NTATLTISRVEAGDEADYYCQVWDSSSDH...
VBase_VL3_7    11-7      3e         SYELTQL.PSVSVSPGQTARITCSGD...VLGE.....NYADWYQQKPGQAPELVIYE........DSERYPGIPERFSGSTSG..NTTTLTISRVLTEDEADYYCLSGDEDN.....
VBase_VL3_8    11-7      3m         SYELMQP.PSVSVSPGQTARITCSGD...ALPK.....QYAYWYQQKPGQAPVLVIYK........DSERPSGIPERFSGSSSG..TTVTLTISGVQAEDEADYYCQSADSSGTY...
VBase_VL3_9    11-7      2-19       SYELTQP.SSVSVSPGQTARITCSGD...VLAK.....KYARWFQQKPGQAPVLVIYK........DSERPSGIPERFSGSSSG..TTVTLTISGAQVEDEADYYCYSAADNN.....

VBase_VL4_1    12-11     4c         LPVLTQP.PSASALLGASIKLTCTLSS..EHST.....YTIEWYQQRPGRSPQYIMKVKS....DGSHSKGDGIPDRFMGSSSG..ADRYLTFSNLQSDDEAEYHCGESHTIDGQVG*
VBase_VL4_2    12-11     4a         QPVLTQS.SSASASLGSSVKLTCTLSS..GHSS.....YIIAWHQQQPGKAPRYLMKLEG....SGSYNKGSGVPDRFSGSSSG..ADRYLTISNLQLEDEADYYCETWDSNT.....
VBase_VL4_3    12-11     4b         QLVLTQS.PSASASLGASVKLTCTLSS..GHSS.....YAIAWHQQQPEKGPRYLMKLNS....DGSHSKGDGIPDRFSGSSSG..AERYLTISSLQSEDEADYYCQTWGTGI.....

VBase_VL4_1    14-11     5e         QPVLTQP.PSSSASPGESARLTCTLPS.DINVGS....YNIYWYQQKPGSPPRYLLYYYS....DSDKGQGSGVPSRFSGSKDASANTGILLISGLQSEDEADYYCMIWPSNAS....
VBase_VL4_2    14-11     5c         QAVLTQP.ASLSASPGASASLTCTLRS.GINVGT....YRIYWYQQKPGSPPQYLLRYKS....DSDKQQGSGVPSRFSGSKDASANAGILLISGLQSEDEADYYCMIWHSSAS....
VBase_VL4_3    14-11     5b         QPVLTQP.SSHSASSGASVRLTCMLSS.GFSVGD....FWIRWYQQKPGNPPRYLLYYHS....DSNKGQGSGVPSRFSGSNDASANAGILRISGLQPEDEADYYCGTWHSNSKT...

VBase_VL5_1    13-7(B)   6a         NFMLTQP.HSVSESPGKTVTISCTRSS.GSIAS.....NYVQWYQQRPGSSPTTVIYE........DNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSN.....

VBase_VL6_1    14-7(B)   7a         QTVVTQE.PSLTVSPGGTVTLTCASST.GAVTSG....YYPNWFQQKPGQAPRALIYS........TSNKHSWTPARFSGSLLG..GKAALTLSGVQPEDEAEYYCLLYYGGAQ....
VBase_VL6_2    14-7(B)   7b         QAVVTQE.PSLTVSPGGTVTLTCGSST.GAVTSG....HYPYWFQQKPGQAPRTLIYD........TSNKHSWTPARFSGSLLG..GKAALTLSGAQPEDEAEYYCLLSYSGAR....

VBase_VL7_1    14-7(B)   8a         QTVVTQE.PSFSVSPGGTVTLTCGLSS.GSVSTS....YYPSWYQQTPGQAPRTLIYS........TNTRSSGVPDRFSGSILG..NKAALTITGAQADDESDYYCVLYMGSGI....

VBase_VL8_1    12-12     9a         QPVLTQP.PSASASLGASVTLTCTLS..SGYSN.....YKVDWYQQRPGKGPRFVMRVGTG...GIVGSKGDGIPDRFSVLGSG..LNRYLTIKNIQEEDESDYHCGADHGSGSNFV*

VBase_VL9_1    13-7(C)   10a        QAGLTQP.PSVSKGLRQTATLTCTGNS.NNVGN.....QGAAWLQQHQGHPPKLLSYR........NNNRPSGISERLSASRSG..NTASLTITGLQPEDEADYYCSAWDSSLSA...

AHonegger, June 6, 2001