Human V lambda Germline Sequences (VBase)
111111111122222222 222222 22333333333344444444445 555555555666666666 677777777778888888888999999999999
Kabat V lambda 123456789012345678901234567 777777 89012345678901234567890 123456789012345678 901234567890123456789012345555555
abcd4f abcdef
CDR (x) ....:....|....:....|...xxxxxxxxxxxxxxxxxxx..:....|....:..xxxxxxxxxxxxxxx..:....|....:....|....:....|....:.xxxxxxxxxxxxx
11111111111111111111
11111111112222222222333333333344444444445555555555666666666677777777778888888888999999999900000000001111111111
AH0 12345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789
....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....
VBase_VL1_1 13-7(A) 1a QSVLTQP.PSVSEAPRQRVTISCSGSS.SNIGN.....NAVNWYQQLPGKAPKLLIYY........DDLLPSGVSDRFSGSKSG..TSASLAISGLQSEDEADYYCAAWDDSLNG...
VBase_VL1_2 14-7(A) 1e QSVLTQP.PSVSGAPGQRVTISCTGSS.SNIGAG....YDVHWYQQLPGTAPKLLIYG........NSNRPSGVPDRFSGSKSG..TSASLAITGLQAEDEADYYCQSYDSSLSG...
VBase_VL1_3 13-7(A) 1c QSVLTQP.PSASGTPGQRVTISCSGSS.SNIGS.....NTVNWYQQLPGTAPKLLIYS........NNQRPSGVPDRFSGSKSG..TSASLAISGLQSEDEADYYCAAWDDSLNG...
VBase_VL1_4 13-7(A) 1g QSVLTQP.PSASGTPGQRVTISCSGSS.SNIGS.....NYVYWYQQLPGTAPKLLIYR........NNQRPSGVPDRFSGSKSG..TSASLAISGLRSEDEADYYCAAWDDSLSG...
VBase_VL1_5 13-7(A) 1b QSVLTQP.PSVSAAPGQKVTISCSGSS.SNIGN.....NYVSWYQQLPGTAPKLLIYD........NNKRPSGIPDRFSGSKSG..TSATLGITGLQTGDEADYYCGTWDSSLSA...
VBase_VL2_1 14-7(A) 2c QSALTQP.PSASGSPGQSVTISCTGTS.SDVGGY....NYVSWYQQHPGKAPKLMIYE........VSKRPSGVPDRFSGSKSG..NTASLTVSGLQAEDEADYYCSSYAGSNNF...
VBase_VL2_2 14-7(A) 2e QSALTQP.RSVSGSPGQSVTISCTGTS.SDVGGY....NYVSWYQQHPGKAPKLMIYD........VSKRPSGVPDRFSGSKSG..NTASLTISGLQAEDEADYYCCSYAGSYTF...
VBase_VL2_3 14-7(A) 2a2 QSALTQP.ASVSGSPGQSITISCTGTS.SDVGGY....NYVSWYQQHPGKAPKLMIYE........VSNRPSGVSNRFSGSKSG..NTASLTISGLQAEDEADYYCSSYTSSSTL...
VBase_VL2_4 14-7(A) 2d QSALTQP.PSVSGSPGQSVTISCTGTS.SDVGSY....NRVSWYQQPPGTAPKLMIYE........VSNRPSGVPDRFSGSKSG..NTASLTISGLQAEDEADYYCSLYTSSSTF...
VBase_VL2_5 14-7(A) 2b2 QSALTQP.ASVSGSPGQSITISCTGTS.SDVGSY....NLVSWYQQHPGKAPKLMIYE........VSKRPSGVSNRFSGSKSG..NTASLTISGLQAEDEADYYCCSYAGSSTF...
VBase_VL3_1 11-7 3r SYELTQP.PSVSVSPGQTASITCSGD...KLGD.....KYACWYQQKPGQSPVLVIYQ........DSKRPSGIPERFSGSNSG..NTATLTISGTQAMDEADYYCQAWDSSTA....
VBase_VL3_2 11-7 3j SYELTQP.LSVSVALGQTARITCGGN...NIGS.....KNVHWYQQKPGQAPVLVIYR........DSNRPSGIPERFSGSNSG..NTATLTISRAQAGDEADYYCQVWDSSTA....
VBase_VL3_3 11-7 3p SYELTQP.PSVSVSPGQTARITCSGD...ALPK.....KYAYWYQQKSGQAPVLVIYE........DSKRPSGIPERFSGSSSG..TMATLTISGAQVEDEADYYCYSTDSSGNH...
VBase_VL3_4 11-7 3a SYELTQP.PSVSVSLGQMARITCSGE...ALPK.....KYAYWYQQKPGQFPVLVIYK........DSERPSGIPERFSGSSSG..TIVTLTISGVQAEDEADYYCLSADSSGTY...
VBase_VL3_5 11-7 3l SSELTQD.PAVSVALGQTVRITCQGD...SLRS.....YYASWYQQKPGQAPVLVIYG........KNNRPSGIPDRFSGSSSG..NTASLTITGAQAEDEADYYCNSRDSSGNH...
VBase_VL3_6 11-7 3h SYVLTQP.PSVSVAPGKTARITCGGN...NIGS.....KSVHWYQQKPGQAPVLVIYY........DSDRPSGIPERFSGSNSG..NTATLTISRVEAGDEADYYCQVWDSSSDH...
VBase_VL3_7 11-7 3e SYELTQL.PSVSVSPGQTARITCSGD...VLGE.....NYADWYQQKPGQAPELVIYE........DSERYPGIPERFSGSTSG..NTTTLTISRVLTEDEADYYCLSGDEDN.....
VBase_VL3_8 11-7 3m SYELMQP.PSVSVSPGQTARITCSGD...ALPK.....QYAYWYQQKPGQAPVLVIYK........DSERPSGIPERFSGSSSG..TTVTLTISGVQAEDEADYYCQSADSSGTY...
VBase_VL3_9 11-7 2-19 SYELTQP.SSVSVSPGQTARITCSGD...VLAK.....KYARWFQQKPGQAPVLVIYK........DSERPSGIPERFSGSSSG..TTVTLTISGAQVEDEADYYCYSAADNN.....
VBase_VL4_1 12-11 4c LPVLTQP.PSASALLGASIKLTCTLSS..EHST.....YTIEWYQQRPGRSPQYIMKVKS....DGSHSKGDGIPDRFMGSSSG..ADRYLTFSNLQSDDEAEYHCGESHTIDGQVG*
VBase_VL4_2 12-11 4a QPVLTQS.SSASASLGSSVKLTCTLSS..GHSS.....YIIAWHQQQPGKAPRYLMKLEG....SGSYNKGSGVPDRFSGSSSG..ADRYLTISNLQLEDEADYYCETWDSNT.....
VBase_VL4_3 12-11 4b QLVLTQS.PSASASLGASVKLTCTLSS..GHSS.....YAIAWHQQQPEKGPRYLMKLNS....DGSHSKGDGIPDRFSGSSSG..AERYLTISSLQSEDEADYYCQTWGTGI.....
VBase_VL4_1 14-11 5e QPVLTQP.PSSSASPGESARLTCTLPS.DINVGS....YNIYWYQQKPGSPPRYLLYYYS....DSDKGQGSGVPSRFSGSKDASANTGILLISGLQSEDEADYYCMIWPSNAS....
VBase_VL4_2 14-11 5c QAVLTQP.ASLSASPGASASLTCTLRS.GINVGT....YRIYWYQQKPGSPPQYLLRYKS....DSDKQQGSGVPSRFSGSKDASANAGILLISGLQSEDEADYYCMIWHSSAS....
VBase_VL4_3 14-11 5b QPVLTQP.SSHSASSGASVRLTCMLSS.GFSVGD....FWIRWYQQKPGNPPRYLLYYHS....DSNKGQGSGVPSRFSGSNDASANAGILRISGLQPEDEADYYCGTWHSNSKT...
VBase_VL5_1 13-7(B) 6a NFMLTQP.HSVSESPGKTVTISCTRSS.GSIAS.....NYVQWYQQRPGSSPTTVIYE........DNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSN.....
VBase_VL6_1 14-7(B) 7a QTVVTQE.PSLTVSPGGTVTLTCASST.GAVTSG....YYPNWFQQKPGQAPRALIYS........TSNKHSWTPARFSGSLLG..GKAALTLSGVQPEDEAEYYCLLYYGGAQ....
VBase_VL6_2 14-7(B) 7b QAVVTQE.PSLTVSPGGTVTLTCGSST.GAVTSG....HYPYWFQQKPGQAPRTLIYD........TSNKHSWTPARFSGSLLG..GKAALTLSGAQPEDEAEYYCLLSYSGAR....
VBase_VL7_1 14-7(B) 8a QTVVTQE.PSFSVSPGGTVTLTCGLSS.GSVSTS....YYPSWYQQTPGQAPRTLIYS........TNTRSSGVPDRFSGSILG..NKAALTITGAQADDESDYYCVLYMGSGI....
VBase_VL8_1 12-12 9a QPVLTQP.PSASASLGASVTLTCTLS..SGYSN.....YKVDWYQQRPGKGPRFVMRVGTG...GIVGSKGDGIPDRFSVLGSG..LNRYLTIKNIQEEDESDYHCGADHGSGSNFV*
VBase_VL9_1 13-7(C) 10a QAGLTQP.PSVSKGLRQTATLTCTGNS.NNVGN.....QGAAWLQQHQGHPPKLLSYR........NNNRPSGISERLSASRSG..NTASLTITGLQPEDEADYYCSAWDSSLSA...
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AHonegger, June 6, 2001