Human V kappa Germline Sequences (VBase)

                                             111111111122222222 222222 22333333333344444444445        555555555666666666  677777777778888888888999999999999
Kabat V kappa                       123456789012345678901234567 777777 89012345678901234567890        123456789012345678  901234567890123456789012345555555
                                                                abcd4f                                                                               abcdef
CDR (x)                             ....:....|....:....|...xxxxxxxxxxxxxxxxxxx..:....|....:..xxxxxxxxxxxxxxx..:....|....:....|....:....|....:.xxxxxxxxxxxxx
                                                                                                                                       11111111111111111111
                                             11111111112222222222333333333344444444445555555555666666666677777777778888888888999999999900000000001111111111
AH0                                 12345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789
                                    ....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....
VBase_VK1_1    2-1-(1)   O12        DIQMTQSPSSLSASVGDRVTITCRASQ..SISS......YLNWYQQKPGKAPKLLIYA........ASSLQSGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCQQSYSTP.....
VBase_VK1_2    2-1-(1)   O2         DIQMTQSPSSLSASVGDRVTITCRASQ..SISS......YLNWYQQKPGKAPKLLIYA........ASSLQSGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCQQSYSTP.....
VBase_VK1_3    2-1-(1)   O18        DIQMTQSPSSLSASVGDRVTITCQASQ..DISN......YLNWYQQKPGKAPKLLIYD........ASNLETGVPSRFSGSGSG..TDFTFTISSLQPEDIATYYCQQYDNLP.....
VBase_VK1_4    2-1-(1)   O8         DIQMTQSPSSLSASVGDRVTITCQASQ..DISN......YLNWYQQKPGKAPKLLIYD........ASNLETGVPSRFSGSGSG..TDFTFTISSLQPEDIATYYCQQYDNLP.....
VBase_VK1_5    2-1-(U)   A20        DIQMTQSPSSLSASVGDRVTITCRASQ..GISN......YLAWYQQKPGKVPKLLIYA........ASTLQSGVPSRFSGSGSG..TDFTLTISSLQPEDVATYYCQKYNSAP.....
VBase_VK1_6    2-1-(1)   A30        DIQMTQSPSSLSASVGDRVTITCRASQ..GIRN......DLGWYQQKPGKAPKRLIYA........ASSLQSGVPSRFSGSGSG..TEFTLTISSLQPEDFATYYCLQHNSYP.....
VBase_VK1_7    2-1-(1)   L14        NIQMTQSPSAMSASVGDRVTITCRARQ..GISN......YLAWFQQKPGKVPKHLIYA........ASSLQSGVPSRFSGSGSG..TEFTLTISSLQPEDFATYYCLQHNSYP.....
VBase_VK1_8    2-1-(1)   L1         DIQMTQSPSSLSASVGDRVTITCRASQ..GISN......YLAWFQQKPGKAPKSLIYA........ASSLQSGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCQQYNSYP.....
VBase_VK1_9    2-1-(1)   L15        DIQMTQSPSSLSASVGDRVTITCRASQ..GISS......WLAWYQQKPEKAPKSLIYA........ASSLQSGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCQQYNSYP.....
VBase_VK1_10   2-1-(1)   L4         AIQLTQSPSSLSASVGDRVTITCRASQ..GISS......ALAWYQQKPGKAPKLLIYD........ASSLESGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCQQFNSYP.....
VBase_VK1_11   2-1-(1)   L18        AIQLTQSPSSLSASVGDRVTITCRASQ..GISS......ALAWYQQKPGKAPKLLIYD........ASSLESGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCQQFNSYP.....
VBase_VK1_12   2-1-(1)   L5         DIQMTQSPSSVSASVGDRVTITCRASQ..GISS......WLAWYQQKPGKAPKLLIYA........ASSLQSGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCQQANSFP.....
VBase_VK1_13   2-1-(1)   L19        DIQMTQSPSSVSASVGDRVTITCRASQ..GISS......WLAWYQQKPGKAPKLLIYA........ASSLQSGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCQQANSFP.....
VBase_VK1_14   2-1-(1)   L8         DIQLTQSPSFLSASVGDRVTITCRASQ..GISS......YLAWYQQKPGKAPKLLIYA........ASTLQSGVPSRFSGSGSG..TEFTLTISSLQPEDFATYYCQQLNSYP.....
VBase_VK1_15   2-1-(1)   L23        AIRMTQSPFSLSASVGDRVTITCWASQ..GISS......YLAWYQQKPAKAPKLFIYY........ASSLQSGVPSRFSGSGSG..TDYTLTISSLQPEDFATYYCQQYYSTP.....
VBase_VK1_16   2-1-(1)   L9         AIRMTQSPSSFSASTGDRVTITCRASQ..GISS......YLAWYQQKPGKAPKLLIYA........ASTLQSGVPSRFSGSGSG..TDFTLTISCLQSEDFATYYCQQYYSYP.....
VBase_VK1_17   U-1-(1)   L24        VIWMTQSPSLLSASTGDRVTISCRMSQ..GISS......YLAWYQQKPGKAPELLIYA........ASTLQSGVPSRFSGSGSG..TDFTLTISCLQSEDFATYYCQQYYSFP.....
VBase_VK1_18   2-1-(1)   L11        AIQMTQSPSSLSASVGDRVTITCRASQ..GIRN......DLGWYQQKPGKAPKLLIYA........ASSLQSGVPSRFSGSGSG..TDFTLTISSLQPEDFATYYCLQDYNYP.....
VBase_VK1_19   2-1-(U)   L12        DIQMTQSPSTLSASVGDRVTITCRASQ..SISS......WLAWYQQKPGKAPKLLIYD........ASSLESGVPSRFSGSGSG..TEFTLTISSLQPDDFATYYCQQYNSYS.....

VBase_VK2_1    3-1-(1)   O11        DIVMTQTPLSLPVTPGEPASISCRSSQ..SLLDSDDGNTYLDWYLQKPGQSPQLLIYT........LSYRASGVPDRFSGSGSG..TDFTLKISRVEAEDVGVYYCMQRIEFP.....
VBase_VK2_2    3-1-(1)   O1         DIVMTQTPLSLPVTPGEPASISCRSSQ..SLLDSDDGNTYLDWYLQKPGQSPQLLIYT........LSYRASGVPDRFSGSGSG..TDFTLKISRVEAEDVGVYYCMQRIEFP.....
VBase_VK2_3    4-1-(1)   A17        DVVMTQSPLSLPVTLGQPASISCRSSQ..SLVYSD.GNTYLNWFQQRPGQSPRRLIYK........VSNRDSGVPDRFSGSGSG..TDFTLKISRVEAEDVGVYYCMQGTHWP.....
VBase_VK2_4    4-1-(1)   A1         DVVMTQSPLSLPVTLGQPASISCRSSQ..SLVYSD.GNTYLNWFQQRPGQSPRRLIYK........VSNWDSGVPDRFSGSGSG..TDFTLKISRVEAEDVGVYYCMQGTHWP.....
VBase_VK2_5    4-1-(1)   A18        DIVMTQTPLSLSVTPGQPASISCKSSQ..SLLHSD.GKTYLYWYLQKPGQSPQLLIYE........VSSRFSGVPDRFSGSGSG..TDFTLKISRVEAEDVGVYYCMQGIHLP.....
VBase_VK2_6    4-1-(1)   A2         DIVMTQTPLSLSVTPGQPASISCKSSQ..SLLHSD.GKTYLYWYLQKPGQPPQLLIYE........VSNRFSGVPDRFSGSGSG..TDFTLKISRVEAEDVGVYYCMQSIQLP.....
VBase_VK2_7    4-1-(1)   A19        DIVMTQSPLSLPVTPGEPASISCRSSQ..SLLHSN.GYNYLDWYLQKPGQSPQLLIYL........GSNRASGVPDRFSGSGSG..TDFTLKISRVEAEDVGVYYCMQALQTP.....
VBase_VK2_8    4-1-(1)   A3         DIVMTQSPLSLPVTPGEPASISCRSSQ..SLLHSN.GYNYLDWYLQKPGQSPQLLIYL........GSNRASGVPDRFSGSGSG..TDFTLKISRVEAEDVGVYYCMQALQTP.....
VBase_VK2_9    4-1-(1)   A23        DIVMTQTPLSSPVTLGQPASISCRSSQ..SLVHSD.GNTYLSWLQQRPGQPPRLLIYK........ISNRFSGVPDRFSGSGAG..TDFTLKISRVEAEDVGVYYCMQATQFP.....

VBase_VK3_1    6-1-(1)   A27        EIVLTQSPGTLSLSPGERATLSCRASQ..SVSS.....SYLAWYQQKPGQAPRLLIYG........ASSRATGIPDRFSGSGSG..TDFTLTISRLEPEDFAVYYCQQYGSSP.....
VBase_VK3_2    6-1-(1)   A11        EIVLTQSPATLSLSPGERATLSCGASQ..SVSS.....SYLAWYQQKPGLAPRLLIYD........ASSRATGIPDRFSGSGSG..TDFTLTISRLEPEDFAVYYCQQYGSSP.....
VBase_VK3_3    2-1-(1)   L2         EIVMTQSPATLSVSPGERATLSCRASQ..SVSS......NLAWYQQKPGQAPRLLIYG........ASTRATGIPARFSGSGSG..TEFTLTISSLQSEDFAVYYCQQYNNWP.....
VBase_VK3_4    2-1-(1)   L16        EIVMTQSPATLSVSPGERATLSCRASQ..SVSS......NLAWYQQKPGQAPRLLIYG........ASTRATGIPARFSGSGSG..TEFTLTISSLQSEDFAVYYCQQYNNWP.....
VBase_VK3_5    2-1-(1)   L6         EIVLTQSPATLSLSPGERATLSCRASQ..SVSS......YLAWYQQKPGQAPRLLIYD........ASNRATGIPARFSGSGSG..TDFTLTISSLEPEDFAVYYCQQRSNWP.....
VBase_VK3_6    2-1-(U)   L20        EIVLTQSPATLSLSPGERATLSCRASQ..GVSS......YLAWYQQKPGQAPRLLIYD........ASNRATGIPARFSGSGPG..TDFTLTISSLEPEDFAVYYCQQRSNWH.....
VBase_VK3_7    6-1-(1)   L25        EIVMTQSPATLSLSPGERATLSCRASQ..SVSS.....SYLSWYQQKPGQAPRLLIYG........ASTRATGIPARFSGSGSG..TDFTLTISSLQPEDFAVYYCQQDYNLP.....

VBase_VK4_1    3-1-(1)   B3         DIVMTQSPDSLAVSLGERATINCKSSQ..SVLYSSNNKNYLAWYQQKPGQPPKLLIYW........ASTRESGVPDRFSGSGSG..TDFTLTISSLQAEDVAVYYCQQYYSTP.....

VBase_VK5_1    2-1-(1)   B2         ETTLTQSPAFMSATPGDKVNISCKASQ..DID......DDMNWYQQKPGEAAIFIIQE........ATTLVPGIPPRFSGSGYG..TDFTLTINNIESEDAAYYFCLQHDNFP.....

VBase_VK6_1    2-1-(1)   A26        EIVLTQSPDFQSVTPKEKVTITCRASQ..SIG......SSLHWYQQKPDQSPKLLIKY........ASQSFSGVPSRFSGSGSG..TDFTLTINSLEAEDAATYYCHQSSSLP.....
VBase_VK6_2    2-1-(1)   A10        EIVLTQSPDFQSVTPKEKVTITCRASQ..SIG......SSLHWYQQKPDQSPKLLIKY........ASQSFSGVPSRFSGSGSG..TDFTLTINSLEAEDAATYYCHQSSSLP.....
VBase_VK6_3    2-1-(1)   A14        DVVMTQSPAFLSVTPGEKVTITCQASE..GIG......NYLYWYQQKPDQAPKLLIKY........ASQSISGVPSRFSGSGSG..TDFTFTISSLEAEDAATYYCQQGNKHP.....

AHonegger, June 6, 2001