Human VH Germline  Sequences (VBase)
                                                                                                                                                     1111111111
                                              11111111112222222 22233333333   33334444444444555555 555555566666666667777777777888888888888899999999990000000000
Kabat VH                            1234567 8901234567890123456 78901234555   67890123456789012222 345678901234567890123456789012222345678901234567890000000000
                                                                         ab                    abc                               abc                  abcdefghI
                                    ....:....|....:....|....:....|..xxxxxxxxxx..:....|....:.xxxxxxxxxxxxxxxxxxxx...|....:....|....:....|....:...xxxxxxxxxxxxxxx
                                                                                                                                       111111111111111111111111
                                             111111111122222222223333333333444444444455555555556666666666777777777788888888889999999999000000000011111111111111
AH0                                 123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123
                                    ....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|
VBase_VH2_1    1-3       1-02       QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTG.....YYMHWVRQAPGQGLEWMGWINPN...SGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCAR...............
VBase_VH2_2    1-3       1-03       QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTS.....YAMHWVRQAPGQRLEWMGWINAG...NGNTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCAR...............
VBase_VH2_3    1-3       1-08       QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTS.....YDINWVRQATGQGLEWMGWMNPN...SGNTGYAQKFQGRVTMTRNTSISTAYMELSSLRSEDTAVYYCAR...............
VBase_VH2_4    1-2       1-18       QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTS.....YGISWVRQAPGQGLEWMGWISAY...NGNTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCAR...............
VBase_VH2_5    1-U       1-24       QVQLVQS.GAEVKKPGASVKVSCKVSG.YTLTE.....LSMHWVRQAPGKGLEWMGGFDPE...DGETIYAQKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCAT...............
VBase_VH2_6    1-3       1-45       QMQLVQS.GAEVKKTGSSVKVSCKASG.YTFTY.....RYLHWVRQAPGQALEWMGWITPF...NGNTNYAQKFQDRVTITRDRSMSTAYMELSSLRSEDTAMYYCAR...............
VBase_VH2_7    1-3       1-46       QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTS.....YYMHWVRQAPGQGLEWMGIINPS...GGSTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAR...............
VBase_VH2_8    1-3       1-58       QMQLVQS.GPEVKKPGTSVKVSCKASG.FTFTS.....SAVQWVRQARGQRLEWIGWIVVG...SGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAA...............
VBase_VH2_9    1-2       1-69       QVQLVQS.GAEVKKPGSSVKVSCKASG.GTFSS.....YAISWVRQAPGQGLEWMGGIIPI...FGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCAR...............
VBase_VH2_10   1-2       1-e        QVQLVQS.GAEVKKPGSSVKVSCKASG.GTFSS.....YAISWVRQAPGQGLEWMGGIIPI...FGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCAR...............
VBase_VH2_11   1-2       1-f        EVQLVQS.GAEVKKPGATVKISCKVSG.YTFTD.....YYMHWVQQAPGKGLEWMGLVDPE...DGETIYAEKFQGRVTITADTSTDTAYMELSSLRSEDTAVYYCAT...............

VBase_VH2_1    3-1/2-1   2-05       QITLKES.GPTLVKPTQTLTLTCTFSG.FSLSTS...GVGVGWIRQPPGKALEWLALIYW....NDDKRYSPSLKSRLTITKDTSKNQVVLTMTNMDPVDTATYYCAHR..............
VBase_VH2_2    3-1       2-26       QVTLKES.GPVLVKPTETLTLTCTVSG.FSLSNA...RMGVSWIRQPPGKALEWLAHIFS....NDEKSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARI..............
VBase_VH2_3    3-1       2-70       QVTLKES.GPALVKPTQTLTLTCTFSG.FSLSTS...GMRVSWIRQPPGKALEWLARIDW....DDDKFYSTSLKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARI..............

VBase_VH3_1    1-3       3-07       EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YWMSWVRQAPGKGLEWVANIKQD...GSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_2    1-3       3-09       EVQLVES.GGGLVQPGRSLRLSCAASG.FTFDD.....YAMHWVRQAPGKGLEWVSGISWN...SGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKD..............
VBase_VH3_3    1-3       3-11       QVQLVES.GGGLVKPGGSLRLSCAASG.FTFSD.....YYMSWIRQAPGKGLEWVSYISSS...GSTIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_4    1-1       3-13       EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YDMHWVRQATGKGLEWVSAIGT....AGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCAR...............
VBase_VH3_5    1-U       3-15       EVQLVES.GGGLVKPGGSLRLSCAASG.FTFSN.....AWMSWVRQAPGKGLEWVGRIKSKT.DGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTT...............
VBase_VH3_6    1-3       3-20       EVQLVES.GGGVVRPGGSLRLSCAASG.FTFDD.....YGMSWVRQAPGKGLEWVSGINWN...GGSTGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYHCAR...............
VBase_VH3_7    1-3       3-21       EVQLVES.GGGLVKPGGSLRLSCAASG.FTFSS.....YSMNWVRQAPGKGLEWVSSISSS...SSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_8    1-3       3-23       EVQLLES.GGGLVQPGGSLRLSCAASG.FTFSS.....YAMSWVRQAPGKGLEWVSAISGS...GGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK...............
VBase_VH3_9    1-3       3-30       QVQLVES.GGGVVQPGRSLRLSCAASG.FTFSS.....YGMHWVRQAPGKGLEWVAVISYD...GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK...............
VBase_VH3_10   1-3       3-30.3     QVQLVES.GGGVVQPGRSLRLSCAASG.FTFSS.....YAMHWVRQAPGKGLEWVAVISYD...GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_11   1-3       3-30.5     QVQLVES.GGGVVQPGRSLRLSCAASG.FTFSS.....YGMHWVRQAPGKGLEWVAVISYD...GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK...............
VBase_VH3_12   1-3       3-33       QVQLVES.GGGVVQPGRSLRLSCAASG.FTFSS.....YGMHWVRQAPGKGLEWVAVIWYD...GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_13   1-3       3-43       EVQLVES.GGVVVQPGGSLRLSCAASG.FTFDD.....YTMHWVRQAPGKGLEWVSLISWD...GGSTYYADSVKGRFTISRDNSKNSLYLQMNSLRTEDTALYYCAKD..............
VBase_VH3_14   1-3       3-48       EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YSMNWVRQAPGKGLEWVSYISSS...SSTIYYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCAR...............
VBase_VH3_15   1-U       3-49       EVQLVES.GGGLVQPGRSLRLSCTASG.FTFGD.....YAMSWFRQAPGKGLEWVGFIRSKA.YGGTTEYTASVKGRFTISRDGSKSIAYLQMNSLKTEDTAVYYCTR...............
VBase_VH3_16   1-1       3-53       EVQLVET.GGGLIQPGGSLRLSCAASG.FTVSS.....NYMSWVRQAPGKGLEWVSVIYS....GGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_17   1-3       3-64       EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YAMHWVRQAPGKGLEYVSAISSN...GGSTYYANSVKGRFTISRDNSKNTLYLQMGSLRAEDMAVYYCAR...............
VBase_VH3_18   1-1       3-66       EVQLVES.GGGLVQPGGSLRLSCAASG.FTVSS.....NYMSWVRQAPGKGLEWVSVIYS....GGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_19   1-4       3-72       EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSD.....HYMDWVRQAPGKGLEWVGRTRNKA.NSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAR...............
VBase_VH3_20   1-4       3-73       EVQLVES.GGGLVQPGGSLKLSCAASG.FTFSG.....SAMHWVRQASGKGLEWVGRIRSKA.NSYATAYAASVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCTR...............
VBase_VH3_21   1-3       3-74       EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YWMHWVRQAPGKGLVWVSRINSD...GSSTSYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_22   1-6       3-d        EVQLVES.RGVLVQPGGSLRLSCAASG.FTVSS.....NEMSWVRQAPGKGLEWVSSISG.....GSTYYADSRKGRFTISRDNSKNTLHLQMNSLRAEDTAVYYCKK...............

VBase_VH4_1    2-1/1-1   4-04       QVQLQES.GPGLVKPSGTLSLTCAVSG.GSISSS....NWWSWVRQPPGKGLEWIGEIYH....SGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_2    2-1       4-28       QVQLQES.GPGLVKPSDTLSLTCAVSG.YSISSS....NWWGWIRQPPGKGLEWIGYIYY....SGSTYYNPSLKSRVTMSVDTSKNQFSLKLSSVTAVDTAVYYCAR...............
VBase_VH4_3    3-1       4-30.1     QVQLQES.GPGLVKPSQTLSLTCTVSG.GSISSG...GYYWSWIRQHPGKGLEWIGYIYY....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_4    3-1       4-30.2     QLQLQES.GSGLVKPSQTLSLTCAVSG.GSISSG...GYSWSWIRQPPGKGLEWIGYIYH....SGSTYYNPSLKSRVTISVDRSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_5    3-1       4-30.4     QVQLQES.GPGLVKPSQTLSLTCTVSG.GSISSG...DYYWSWIRQPPGKGLEWIGYIYY....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_6    3-1       4-31       QVQLQES.GPGLVKPSQTLSLTCTVSG.GSISSG...GYYWSWIRQHPGKGLEWIGYIYY....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_7    1-1       4-34       QVQLQQW.GAGLLKPSETLSLTCAVYG.GSFSG.....YYWSWIRQPPGKGLEWIGEINH....SGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_8    3-1       4-39       QLQLQES.GPGLVKPSETLSLTCTVSG.GSISSS...SYYWGWIRQPPGKGLEWIGSIYY....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_9    1-1       4-59       QVQLQES.GPGLVKPSETLSLTCTVSG.GSISS.....YYWSWIRQPPGKGLEWIGYIYY....SGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_10   3-1       4-61       QVQLQES.GPGLVKPSETLSLTCTVSG.GSVSSG...SYYWSWIRQPPGKGLEWIGYIYY....SGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_11   2-1       4-b        QVQLQES.GPGLVKPSETLSLTCAVSG.YSISSG....YYWGWIRQPPGKGLEWIGSIYH....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............

VBase_VH5_1    1-2       5-51       EVQLVQS.GAEVKKPGESLKISCKGSG.YSFTS.....YWIGWVRQMPGKGLEWMGIIYPG...DSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCAR...............
VBase_VH5_2    1-2       5-a        EVQLVQS.GAEVKKPGESLRISCKGSG.YSFTS.....YWISWVRQMPGKGLEWMGRIDPS...DSYTNYSPSFQGHVTISADKSISTAYLQWSSLKASDTAMYYCAR...............

VBase_VH6_1    3-5       6-01       QVQLQQS.GPGLVKPSQTLSLTCAISG.DSVSSN...SAAWNWIRQSPSRGLEWLGRTYYR..SKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCAR...............

VBase_VH7_1    1-2       7-4.1      QVQLVQS.GSELKKPGASVKVSCKASG.YTFTS.....YAMNWVRQAPGQGLEWMGWINTN...TGNPTYAQGFTGRFVFSLDTSVSTAYLQICSLKAEDTAVYYCAR...............

AHonegger, June 6, 2001