Human VH Germline Sequences (VBase)
1111111111
11111111112222222 22233333333 33334444444444555555 555555566666666667777777777888888888888899999999990000000000
Kabat VH 1234567 8901234567890123456 78901234555 67890123456789012222 345678901234567890123456789012222345678901234567890000000000
ab abc abc abcdefghI
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111111111111111111111111
111111111122222222223333333333444444444455555555556666666666777777777788888888889999999999000000000011111111111111
AH0 123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123
....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|
VBase_VH2_1 1-3 1-02 QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTG.....YYMHWVRQAPGQGLEWMGWINPN...SGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCAR...............
VBase_VH2_2 1-3 1-03 QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTS.....YAMHWVRQAPGQRLEWMGWINAG...NGNTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCAR...............
VBase_VH2_3 1-3 1-08 QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTS.....YDINWVRQATGQGLEWMGWMNPN...SGNTGYAQKFQGRVTMTRNTSISTAYMELSSLRSEDTAVYYCAR...............
VBase_VH2_4 1-2 1-18 QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTS.....YGISWVRQAPGQGLEWMGWISAY...NGNTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCAR...............
VBase_VH2_5 1-U 1-24 QVQLVQS.GAEVKKPGASVKVSCKVSG.YTLTE.....LSMHWVRQAPGKGLEWMGGFDPE...DGETIYAQKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCAT...............
VBase_VH2_6 1-3 1-45 QMQLVQS.GAEVKKTGSSVKVSCKASG.YTFTY.....RYLHWVRQAPGQALEWMGWITPF...NGNTNYAQKFQDRVTITRDRSMSTAYMELSSLRSEDTAMYYCAR...............
VBase_VH2_7 1-3 1-46 QVQLVQS.GAEVKKPGASVKVSCKASG.YTFTS.....YYMHWVRQAPGQGLEWMGIINPS...GGSTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAR...............
VBase_VH2_8 1-3 1-58 QMQLVQS.GPEVKKPGTSVKVSCKASG.FTFTS.....SAVQWVRQARGQRLEWIGWIVVG...SGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAA...............
VBase_VH2_9 1-2 1-69 QVQLVQS.GAEVKKPGSSVKVSCKASG.GTFSS.....YAISWVRQAPGQGLEWMGGIIPI...FGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCAR...............
VBase_VH2_10 1-2 1-e QVQLVQS.GAEVKKPGSSVKVSCKASG.GTFSS.....YAISWVRQAPGQGLEWMGGIIPI...FGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCAR...............
VBase_VH2_11 1-2 1-f EVQLVQS.GAEVKKPGATVKISCKVSG.YTFTD.....YYMHWVQQAPGKGLEWMGLVDPE...DGETIYAEKFQGRVTITADTSTDTAYMELSSLRSEDTAVYYCAT...............
VBase_VH2_1 3-1/2-1 2-05 QITLKES.GPTLVKPTQTLTLTCTFSG.FSLSTS...GVGVGWIRQPPGKALEWLALIYW....NDDKRYSPSLKSRLTITKDTSKNQVVLTMTNMDPVDTATYYCAHR..............
VBase_VH2_2 3-1 2-26 QVTLKES.GPVLVKPTETLTLTCTVSG.FSLSNA...RMGVSWIRQPPGKALEWLAHIFS....NDEKSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARI..............
VBase_VH2_3 3-1 2-70 QVTLKES.GPALVKPTQTLTLTCTFSG.FSLSTS...GMRVSWIRQPPGKALEWLARIDW....DDDKFYSTSLKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARI..............
VBase_VH3_1 1-3 3-07 EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YWMSWVRQAPGKGLEWVANIKQD...GSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_2 1-3 3-09 EVQLVES.GGGLVQPGRSLRLSCAASG.FTFDD.....YAMHWVRQAPGKGLEWVSGISWN...SGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKD..............
VBase_VH3_3 1-3 3-11 QVQLVES.GGGLVKPGGSLRLSCAASG.FTFSD.....YYMSWIRQAPGKGLEWVSYISSS...GSTIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_4 1-1 3-13 EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YDMHWVRQATGKGLEWVSAIGT....AGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCAR...............
VBase_VH3_5 1-U 3-15 EVQLVES.GGGLVKPGGSLRLSCAASG.FTFSN.....AWMSWVRQAPGKGLEWVGRIKSKT.DGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTT...............
VBase_VH3_6 1-3 3-20 EVQLVES.GGGVVRPGGSLRLSCAASG.FTFDD.....YGMSWVRQAPGKGLEWVSGINWN...GGSTGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYHCAR...............
VBase_VH3_7 1-3 3-21 EVQLVES.GGGLVKPGGSLRLSCAASG.FTFSS.....YSMNWVRQAPGKGLEWVSSISSS...SSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_8 1-3 3-23 EVQLLES.GGGLVQPGGSLRLSCAASG.FTFSS.....YAMSWVRQAPGKGLEWVSAISGS...GGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK...............
VBase_VH3_9 1-3 3-30 QVQLVES.GGGVVQPGRSLRLSCAASG.FTFSS.....YGMHWVRQAPGKGLEWVAVISYD...GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK...............
VBase_VH3_10 1-3 3-30.3 QVQLVES.GGGVVQPGRSLRLSCAASG.FTFSS.....YAMHWVRQAPGKGLEWVAVISYD...GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_11 1-3 3-30.5 QVQLVES.GGGVVQPGRSLRLSCAASG.FTFSS.....YGMHWVRQAPGKGLEWVAVISYD...GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK...............
VBase_VH3_12 1-3 3-33 QVQLVES.GGGVVQPGRSLRLSCAASG.FTFSS.....YGMHWVRQAPGKGLEWVAVIWYD...GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_13 1-3 3-43 EVQLVES.GGVVVQPGGSLRLSCAASG.FTFDD.....YTMHWVRQAPGKGLEWVSLISWD...GGSTYYADSVKGRFTISRDNSKNSLYLQMNSLRTEDTALYYCAKD..............
VBase_VH3_14 1-3 3-48 EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YSMNWVRQAPGKGLEWVSYISSS...SSTIYYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCAR...............
VBase_VH3_15 1-U 3-49 EVQLVES.GGGLVQPGRSLRLSCTASG.FTFGD.....YAMSWFRQAPGKGLEWVGFIRSKA.YGGTTEYTASVKGRFTISRDGSKSIAYLQMNSLKTEDTAVYYCTR...............
VBase_VH3_16 1-1 3-53 EVQLVET.GGGLIQPGGSLRLSCAASG.FTVSS.....NYMSWVRQAPGKGLEWVSVIYS....GGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_17 1-3 3-64 EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YAMHWVRQAPGKGLEYVSAISSN...GGSTYYANSVKGRFTISRDNSKNTLYLQMGSLRAEDMAVYYCAR...............
VBase_VH3_18 1-1 3-66 EVQLVES.GGGLVQPGGSLRLSCAASG.FTVSS.....NYMSWVRQAPGKGLEWVSVIYS....GGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_19 1-4 3-72 EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSD.....HYMDWVRQAPGKGLEWVGRTRNKA.NSYTTEYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAR...............
VBase_VH3_20 1-4 3-73 EVQLVES.GGGLVQPGGSLKLSCAASG.FTFSG.....SAMHWVRQASGKGLEWVGRIRSKA.NSYATAYAASVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCTR...............
VBase_VH3_21 1-3 3-74 EVQLVES.GGGLVQPGGSLRLSCAASG.FTFSS.....YWMHWVRQAPGKGLVWVSRINSD...GSSTSYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCAR...............
VBase_VH3_22 1-6 3-d EVQLVES.RGVLVQPGGSLRLSCAASG.FTVSS.....NEMSWVRQAPGKGLEWVSSISG.....GSTYYADSRKGRFTISRDNSKNTLHLQMNSLRAEDTAVYYCKK...............
VBase_VH4_1 2-1/1-1 4-04 QVQLQES.GPGLVKPSGTLSLTCAVSG.GSISSS....NWWSWVRQPPGKGLEWIGEIYH....SGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_2 2-1 4-28 QVQLQES.GPGLVKPSDTLSLTCAVSG.YSISSS....NWWGWIRQPPGKGLEWIGYIYY....SGSTYYNPSLKSRVTMSVDTSKNQFSLKLSSVTAVDTAVYYCAR...............
VBase_VH4_3 3-1 4-30.1 QVQLQES.GPGLVKPSQTLSLTCTVSG.GSISSG...GYYWSWIRQHPGKGLEWIGYIYY....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_4 3-1 4-30.2 QLQLQES.GSGLVKPSQTLSLTCAVSG.GSISSG...GYSWSWIRQPPGKGLEWIGYIYH....SGSTYYNPSLKSRVTISVDRSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_5 3-1 4-30.4 QVQLQES.GPGLVKPSQTLSLTCTVSG.GSISSG...DYYWSWIRQPPGKGLEWIGYIYY....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_6 3-1 4-31 QVQLQES.GPGLVKPSQTLSLTCTVSG.GSISSG...GYYWSWIRQHPGKGLEWIGYIYY....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_7 1-1 4-34 QVQLQQW.GAGLLKPSETLSLTCAVYG.GSFSG.....YYWSWIRQPPGKGLEWIGEINH....SGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_8 3-1 4-39 QLQLQES.GPGLVKPSETLSLTCTVSG.GSISSS...SYYWGWIRQPPGKGLEWIGSIYY....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_9 1-1 4-59 QVQLQES.GPGLVKPSETLSLTCTVSG.GSISS.....YYWSWIRQPPGKGLEWIGYIYY....SGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_10 3-1 4-61 QVQLQES.GPGLVKPSETLSLTCTVSG.GSVSSG...SYYWSWIRQPPGKGLEWIGYIYY....SGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH4_11 2-1 4-b QVQLQES.GPGLVKPSETLSLTCAVSG.YSISSG....YYWGWIRQPPGKGLEWIGSIYH....SGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR...............
VBase_VH5_1 1-2 5-51 EVQLVQS.GAEVKKPGESLKISCKGSG.YSFTS.....YWIGWVRQMPGKGLEWMGIIYPG...DSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCAR...............
VBase_VH5_2 1-2 5-a EVQLVQS.GAEVKKPGESLRISCKGSG.YSFTS.....YWISWVRQMPGKGLEWMGRIDPS...DSYTNYSPSFQGHVTISADKSISTAYLQWSSLKASDTAMYYCAR...............
VBase_VH6_1 3-5 6-01 QVQLQQS.GPGLVKPSQTLSLTCAISG.DSVSSN...SAAWNWIRQSPSRGLEWLGRTYYR..SKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCAR...............
VBase_VH7_1 1-2 7-4.1 QVQLVQS.GSELKKPGASVKVSCKASG.YTFTS.....YAMNWVRQAPGQGLEWMGWINTN...TGNPTYAQGFTGRFVFSLDTSVSTAYLQICSLKAEDTAVYYCAR...............
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AHonegger, June 6, 2001