Murine V kappa Germline Sequences (ABG)

                                                                                111111111122222222 222222 22333333333344444444445        555555555666666666  677777777778888888888999999999999
Kabat V lambda                                                         123456789012345678901234567 777777 89012345678901234567890        123456789012345678  901234567890123456789012345555555
                                                                                                   abcd4f                                                                               abcdef
CDR (x)                                                                ....:....|....:....|...xxxxxxxxxxxxxxxxxxx..:....|....:..xxxxxxxxxxxxxxx..:....|....:....|....:....|....:.xxxxxxxxxxxxx
                                                                                                                                                                          11111111111111111111
                                                                                11111111112222222222333333333344444444445555555555666666666677777777778888888888999999999900000000001111111111
AH0                                                                    12345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789
                                                                       ....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....
ABG_mVK_21_1        21B                           N19-8 scFv (3)   F   NIVLTQSPASLAVSLGQRATISCRASE..SVDSYG..NSFMHWYQQKPGQPPKLLIYL........ASNLESGVPARFSGSGSR..TDFTLTIDPVEADDAATYYCQQNNEDP.....
ABG_mVK_21_2        21C/45.21.1                   PC3741     (0)   F   DIVLTQSPASLAVSLGQRATISCRASE..SVDSYG..NSFMHWYQQKPGQPPKLLIYR........ASNLESGIPARFSGSGSR..TDFTLTINPVEADDVATYYCQQSNEDP.....
ABG_mVK_21_3        18kb                          48.2.1     (7)   F   DIVLTQSPASLAVSLGQRATIFCRASQ..SVDYNG..ISYMHWFQQKPGQPPKLLIYA........ASNLESGIPARFSGSGSG..TDFTLNIHPVEEEDAATYYCQQSIEDP.....
ABG_mVK_21_4        21E/21E                       98QQ       (2)   F   DIVLTQSPASLAVSLGQRATISCRASK..SVSTSG..YSYMHWYQQKPGQPPKLLIYL........ASNLESGVPARFSGSGSG..TDFTLNIHPVEEEDAATYYCQHSRELP.....
ABG_mVK_21_5        1.6kb                         RF-4 PAN   (1)   F   DIVLTQSPASLAVSLGQRATISCRASQ..SVSTSS..YSYMHWYQQKPGQPPKLLIKY........ASNLESGVPARFSGSGSG..TDFTLNIHPVEEEDTATYYCQHSWEIP.....
ABG_mVK_21_6        21G                           S4 5A      (1)   F   DIVLTQSPASLAVSLGQRATISCRASE..SVEYYG..TSLMQWYQQKPGQPPKLLIYA........ASNVESGVPARFSGSGSG..TDFSLNIHPVEEDDIAMYFCQQSRKVP.....
ABG_mVK_21_7        21A                           S3 12D     (1)   F   DIVLTQSPASLAVSLGQRATISCRASE..SVDNYG..ISFMNWFQQKPGQPPKLLIYA........ASNQGSGVPARFSGSGSG..TDFSLNIHPMEEDDTAMYFCQQSKEVP.....
ABG_mVK_21_8        P3-X63-Ag8/HNK20                              PS   DIVLTQSPASLAVSLGQRATISYRASK..SVSTSG..YSYMHWNQQKPGQPPRLLIYL........VSNLESGVPARFSGSGSG..TDFTLNIHPVEEEDAATYYCQHIRE.......
ABG_mVK_21_9        CEA 66-E3                                     PS   DIVLTQSPASLAVSLGQRATISYRASK..SVSTSG..YSYMHWNQQKPGQPPRLLIYL........VSNLESGVPARFSGSGSG..TDFTLNIHPVEEEDAATYYCQHI*GAY.....

ABG_mVK_23_1        L7                            A26        (0)   F   DILLTQSPAILSVSPGERVSFSCRASQ..SIGT......SIHWYQQRTNGSPRLLIKY........ASESISGIPSRFSGSGSG..TDFTLSINSVESEDIADYYCQQSNSWP.....
ABG_mVK_23_2        A23A41                                        PS   DVLLTQSPAILSVSPGERVSFSCRASQ..SIGT......SIHWYQQRTNGPPRLLIKY........ASESISGIPSRFSGSGSG..TDFTLSISSVESEDIADYYCQQTNSWP.....
ABG_mVK_23_3        MMIG21                                        PS   DILLTQSPAILSVSPGERVSFSCRASQ..SIGT......SIHWYQQRTNGSPRLLIKN........ASESISGIPSRFSGSGSG..TDFTPSINSVESEDIAEYYCQQSYRWP.....
ABG_mVK_23_4        B1P8-7-2                                      PS   DIVLTQSPATLSVTPGDRVSLSCRASQ..SISN......YLHWYQQKSHESPRLLIKY........ASQSISGIPSRFSGSGSG..TDFTLSINSVETEDFGMYFCQQSNSWX.....
ABG_mVK_23_5        MRL-RF33BL/MRL-n-RF33                         PS   DIVLTQSPATLSVTPGDSVSLSCRASQ..SISN......NLHLYQ*KSHESPRLLIKY........VFQSISEIPSKFSGSGSG..TDFTLSINSVETEDFGMYFCQQSNSWP.....

ABG_mVK_4_5_1       H3/Ox1                        11G3       (0)   F   QIVLTQSPAIMSASPGEKVTMTCSASS..SVS.......YMHWYQQKSGTSPKRWIYD........TSKLASGVPARFSGSGSG..TSYSLTISSMEAEDAATYYCQQWSSNP.....
ABG_mVK_4_5_2       R9                            58.2C.10.3 (2)   F   QIVLTQSPAIMSASPGEKVTMTCSASS..SIS.......YMHWYQQKPGTSPKRWIYD........TSKLASGVPARFSGSGSG..TSYSLTISSMEAEDAATYYCHQRSSYP.....
ABG_mVK_4_5_3       H13                           AN01       (1)   F   QIVLTQSPALMSASPGEKVTMTCSASS..SVS.......YMYWYQQKPRSSPKPWIYL........TSNLASGVPARFSGSGSG..TSYSLTISSMEAEDAATYYCQQWSSNP.....
ABG_mVK_4_5_4       H9                                            NF   QILLTQSPAIMSASPGEKVTMTCSASS..SVS.......YMHWYQQKPGSSPKPWIYD........TSNLASGFPARFSGSGSG..TSYSLIISSMEAEDAATYYCHQRSSYP.....
ABG_mVK_4_5_5       H4                            163.42     (1)   F   QIVLTQSPAIMSASPGEKVTISCSASS..SVS.......YMYWYQQKPGSSPKPWIYR........TSNLASGVPARFSGSGSG..TSYSLTISSMEAEDAATYYCQQYHSYP.....
ABG_mVK_4_5_6       H8                                            PS   QIVLTQSPAILSASPGEKVTMTCSASS..SVS.......YM*WFQQKPGSSPKLWIYS........ISNLASGVPARFSGSGSG..TSYSLTISSVKAEDAATYYCQQWSSSP.....
ABG_mVK_4_5_7       H6/X24                        TEPC191    (0)   F   EIVLTQSPAITAASLGQKVTITCSASS..SVS.......YMHWYQQKSGTSPKPWIYE........ISKLASGVPARFSGSGSG..TSYSLTISSMEAEDAAIYYCQQWNYPL.....
ABG_mVK_4_5_8       R13                           AN09       (3)   F   ENVLTQSPAIMSASLGEKVTMSCRASS..SVN.......YMYWYQQKSDASPKLWIYY........TSNLAPGVPARFSGSGSG..NSYSLTISSMEGEDAATYYCQQFTSSP.....
ABG_mVK_4_5_9       R2                                            NF   EILLTQSPAIIAASPGEKVTITCSASS..SVS.......YMNWYQQKPGSSPKIWIYG........ISNLASGVPARFSGSGSG..TSFSFTINSMEAEDVATYYCQQRSSYP.....
ABG_mVK_4_5_10      H2                                            PS   GIVLTQSPTTMTAFPGENVTITCSASS..SIN.......YIHWYQQKSGNTPKQ*IYK........TSDLPSGVPTLFSGSGSG..TSYSLTISSVEAEDAATYYCQQWSGYP.....
ABG_mVK_4_5_11      H1                            MRL-22     (4)   F   QIVLTQSPAIMSASPGEKVTMTCSARS..SVSS.....SYLYWYQQKPGSSPKLWIYS........TSNLASGVPARFSGSGSG..TSYSLTISSMEAEDAATFYCQQYSQYP.....
ABG_mVK_4_5_12      R1/s107b                      T10-938   (15)   F   ENVLTQSPAIMAASLGQKVTMTCSASS..SVSS.....SYLHWYQQKSGASPKPLIHR........TSNLASGVPARFSGSGSG..TSYSLTISSVEAEDDATYYCQQWSGYP.....
ABG_mVK_4_5_13      T3B                                           PS   ....TQSPAIMAASLGEKVTMTCSASS..SVSS.....SYLHWYQQKSGTSPKPWIYG........TSNLASGVPVRFSGSGSG..TSYSLTISSMEAEDAATYYCQQWSSYP.....
ABG_mVK_4_5_14      L8                                            NF   ENVLTQSPAIMAASLGEKVTMTCSASS..SVSS.....SYLHWYQQKSGTSPKLWIYG........TSNLASGVPARFSGSGAG..ISYSLTISSMEAENDATYYCQQWSGYP.....
ABG_mVK_4_5_15      R11                           18-2-3    (12)   F   ENVLTQSPAIMAASPGEKVTMTCSASS..SVSS.....SNLHWYQQKSGTSTKFWIYR........TSNLASEVPAPFSGSGSG..TSYSLTISSVEAEDAATYYCQQWSGYP.....

ABG_mVK_12_13_1     k2/MMIG27                     SO2        (2)   F   DIQMTQSPASLSASVGETVTITCRASG..NIHN......YLAWYQQKQGKSPQLLVYN........AKTLADGVPSRFSGSGSG..TQYSLKINSLQPEDFGSYYCQHFWSTP.....
ABG_mVK_12_13_2     k3                                            NF   DIQMTQSPASLSVSVGETVTITCRASE..NIYS......NLAWLFSRNRENPPSLVYA........ATNLADGVPSRFSGSGSG..TQYSLKINSQQPEDFGSYYCQHFWSAP.....

ABG_mVK_11_1        V11                                           PS   DVQMTQSPSSLSASLGERVSLTCQASQ..SINN......FLKWFQQTLGKTARLLIYG........ANKLEDGVPSRFSGTGYG..TDFTFTISSQEEEDVSTYFCLQHRYLP.....

ABG_mVK_9A_1        vk41/mpoc41                   202.105   (10)   F   DIQMTQSPSSLSASLGERVSLTCRASQ..DIGS......SLNWLQQEPDGTIKRLIYA........TSSLDSGVPKRFSGSRSG..SDYSLTISSLESEDFVDYYCLQYASSP.....
ABG_mVK_9A_2        m173b                         BXW-16    (24)   F   DIQMTQSPSSLSASLGERVSLTCRASQ..DIHG......YLNLFQQKPGETIKHLIYE........TSNLDSGVPKRFSGSRSG..SDYSLIIGSLESEDFADYYCLQYASSP.....
ABG_mVK_9B_1        L6                            E6         (3)   F   DIKMTQSPSSMYASLGERVTITCKASQ..DINS......YLSWFQQKPGKSPKTLIYR........ANRLVDGVPSRFSGSGSG..QDYSLTISSLEYEDMGIYYCLQYDEFP.....
ABG_mVK_9B_2        9B.8                                          PS   DIQTTQSPSSMSVSLGETVSITCRASQ..GISS......YVSWLQQKPGKSPKTLISY........ATNLEDGITSWFSSSGSG..ADYSLTISSLESEDCKIYYCVQYVQLP.....

ABG_mVK_10_1        Ars/AJ1/Id(CR)/B1P8-7b        Sulf-1     (0)   F   DIQMTQTTSSLSASLGDRVTISCRASQ..DISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEQEDIATYFCQQGNTLP.....
ABG_mVK_10_2        PERU1                         hVH65-107  (1)   F   DIQMTQTTSSLSASLGDRVTISCRASQ..DISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEQEDIATYFCQQGSTLP.....
ABG_mVK_10_3        AKR1                                          NF   DIQMTQTTSSLSASLGDRVTISCRASQ..DISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEQEDIATYFCQQDSKHP.....
ABG_mVK_10_4        AKR2                          44.1       (4)   F   DIQMTQTTSSLSASLGDRVTISCRASQ..DISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEPEDIATYYCQQYSKLP.....
ABG_mVK_10_5        PERU2                                         NF   DIQMTQTTSSLSASLGDRVTISCSASQ..GISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEPEDIATYYCQQYSNLP.....
ABG_mVK_10_6        AJ2/B1P8-7-3                  L2-10CL    (0)   F   DIQMTQTTSSLSASLGDRVTISCSASQ..GISN......YLNWYQQKPDGTVKLLIYY........TSSLHSGVPSRFSGSGSG..TDYSLTISNLEPEDIATYYCQQYSKLP.....
ABG_mVK_10_7        V10                                           PS   DIQMTQTTSSLSASPGDRVTISCRTSQ..DISN......FLYWFQQKSDGTVKLLIYY........TSR*HSGVPSRFSGSGSG..TDYSFTINNLE*EDVATYS*QQGILTL.....

ABG_mVK_24_25_1     167/24                        C57BL 2857 (0)   F   DIVITQDELSNPVTSGESVSISCRSSK..SLLYKD.GKTYLNWFLQRPGQSPQLLIYL........MSTRASGVSDRFSGSGSG..TDFTLEISRVKAEDVGVYYCQQLVEYP.....
ABG_mVK_24_25_2     24A                           H35-C6    (11)   F   DIVMTQAAFSNPVTLGTSASISCRSSK..SLLHSS.GNTYLYWFLQKPGQSPQLLIYY........ISNLASGVPDRFSGSGSG..TDFTLRISRVEAEDVGVYYCMQGLEYP.....
ABG_mVK_24_25_3     24B                           M5         (0)   F   DIVMTQAAFSNPVTLGTSASISCRSSK..SLLHSN.GITYLYWYLQKPGQSPQLLIYQ........MSNLASGVPDRFSSSGSG..TDFTLRISRVEAEDVGVYYCAQNLELP.....

ABG_mVK_1_1         V-1A/K5.1/K5.1                H146-24B3  (0)   F   DVVMTQTPLSLPVSLGDQASISCRSSQ..SLVHSN.GNTYLHWYLQKPGQSPKLLIYK........VSNRFSGVPDRFSGSGSG..TDFTLKISRVEAEDLGVYFCSQSTHVP.....
ABG_mVK_1_2         V-IB                          25.12      (1)   F   DVVMTQTPLSLPVSLGDQASISCRSSQ..SLVHSN.GNTYLYWYLQKPGQSPKLLIYR........VSNRFSGVPDRFSGSGSG..TDFTLKISRVEAEDLGVYFCFQGTHVP.....
ABG_mVK_1_3         V-1C                                          NF   DVVMTQTPLSLPVSLGDQASISCRSSQ..SIVHSN.GNTYLEWYLQKPGQSPKLLIYK........VSNRLSGVPDRFSGSGSG..TDFTLKISRVEAEDLGVYYCFQGSHVP.....
ABG_mVK_1_4         V-1C/V1A5/K1A5                vl6-19     (0)   F   DVLMTQTPLSLPVSLGDQASISCRSSQ..SIVHSN.GNTYLEWYLQKPGQSPKLLIYK........VSNRFSGVPDRFSGSGSG..TDFTLKISRVEAEDLGVYYCFQGSHVP.....
ABG_mVK_1_5         K18.1                         JV3        (0)   F   DAVMTQTPLSLPVSLGDQASISCRSSQ..SLENSN.GNTYLNWYLQKPGQSPQLLIYR........VSNRFSGVLDRFSGSGSG..TDFTLKISRVEAEDLGVYFCLQVTHVP.....
ABG_mVK_1_6         1F                                            PS   DVLLTQTPLFLPVSLGDQASISCSSSQ..SLVHSN.GNYYLEWHLQKSGQSLQLLIYE........VSKRHSGVPDRFSGSGSG..TDFTLKISRVEPEDLGVYYCFQGTHLP.....
ABG_mVK_1_7         1E                                            PS   .......................TSSK..SLVHSN.GNSYLDWHLQKPGQSLQLLIYE........VSKRNSGVPDRFSGSGSG..TDFTLKISRVEPEDLGVYYCFQGTHLP.....

ABG_mVK_2_1         70/2                                          PS   DVVMTQXLHSLSVTIGQPASISCKSSQ..SLLYSN.GKTYLNWLLQRPVQPPKRLIYL........VSKLYSGVPDRFSGSGSG..TDFTLKISRVXPEDLGVY*CMQDTHFP.....
ABG_mVK_2_2         70/3                          LB/C1210.7 (0)   F   DVVMTQTPLTLSVTIGQPASISCKSSQ..SLLDSD.GKTYLNWLLQRPGQSPKRLIYL........VSKLDSGVPDRFTGSGSG..TDFTLKISRVEAEDLGVYYCWQGTHFP.....
ABG_mVK_2_3         70/1                          4G11       (0)   F   DVVMTQTPLTLSVTIGQPASISCKSSQ..SLLYSN.GKTYLNWLLQRPGQSPKRLIYL........VSKLDSGVPDRFTGSGSG..TDFTLKISRVEAEDLGVYYCVQGTHFP.....

ABG_mVK_8_1         ABPC48                                        PS   DIVMTQSPSSLAMSVGQKVTMSCKSSQ..SLLSSSNQKNYLAWYQQKPGQSPKLLVYF........ASTRESGXPDRFIGSGSG..TDFTLTISSVQAEDLALYYCQQHYSTP.....
ABG_mVK_8_2         GLvk50                        D20        (0)   F   DIVMTQSPSSLSVSAGDKVTMSCKSSQ..SLLNSRNQKNYLAWYQQKPWQPPKLLIYG........ASTRESGVPDRFTGSGSG..TDFTLTISSVQAEDLAVYYCQNDYSYP.....

ABG_mVK_19_28_1     V-Serb                        17F12      (7)   F   SIVMTQTPKFLLVSAGERVTITCKASQ..SVSN......DVAWYQQKPGQSPKLLIYY........ASNRYTGVPDRFTGSGYG..TDFTFTISTVQAEDLAVYFCQQDYSSP.....
ABG_mVK_19_28_2     V-Sera                        A34       (22)   F   SIVMTQTPKFLPVSAGDRVTMTCKASQ..SVGN......NVAWYQQKPGQSPKLLIYY........ASNRYTGVPDRFTGSGSG..TDFTFTISSVQVEDLAVYFCQQHYSSP.....
ABG_mVK_19_28_3     SK/CamRK                      AN12      (18)   F   SIVMTQTPKFLPVTAEDRVTITCKASQ..SVSN......EVAWYQQKPGQSPKLLIYY........ASNRYTGVPDRFTGSGSG..TDFTFTISSVQVEDLAVYFCQQHYSSP.....
ABG_mVK_19_28_4     PERA/Ei                       RF49B     (18)   F   SIVMTQSPKSLPVSAGDRVTMTCKASQ..SVSN......DVAWYQQKPGQSPKLLIYY........ASNRYTGVPERFTGSGSG..TDFTFTISGVQAEDLAVYFCQQHYTTP.....

ABG_mVK_32_1        MUSIGKABG                                     PS   DIQMNQSPSSLSASLGDTITITCHASQ..KINV......WLSWYQQKKGNIPKLLIYR........TSNLHTGVPSRFSGSGSG..TGFTLTISSLQPEDIATYYCQQGQNYP.....

ABG_mVK_33_34_1     Vk34A                         165.14    (24)   F   DIQMTQSSSSLSVSLGDRVTITCKASE..HINS......WLAWYQQKPGNAPRLLISG........ATSLETGVPSRFSGSASG..KDYTLSITSLQTEDVAT...............
ABG_mVK_33_34       Vk34B                         T10-421    (6)   F   DIQMTQSSSYLSVSLGGRVTITCKASE..HINS......WLAWYQQKPGNAPRLLISG........ATSLETGVPSRFSGSGSG..KDYTLSITSLQTEDVAT...............
ABG_mVK_33_34       Vk34C                         C8.5      (43)   F   DIQMTQSSSSFSVSLGDRVTITCKASE..DIYN......RLAWYQQKPGNAPRLLISG........ATSLETGVPSRFSGSGSG..KDYTLSITSLQTEDVAT...............

ABG_mVK_20_1        294A9                                         PS   EITVTQSPASLSVATGEKVTIRRITD....IDD......EMH*YQQKPGEPPKLLISE........GNTLHPGVPSQFSSSGYG..TDFFFTIENTLSEDVADYYCLQSGNMP.....

AHonegger, June 6, 2001