Murine V kappa Germline Sequences (ABG)
111111111122222222 222222 22333333333344444444445 555555555666666666 677777777778888888888999999999999
Kabat V lambda 123456789012345678901234567 777777 89012345678901234567890 123456789012345678 901234567890123456789012345555555
abcd4f abcdef
CDR (x) ....:....|....:....|...xxxxxxxxxxxxxxxxxxx..:....|....:..xxxxxxxxxxxxxxx..:....|....:....|....:....|....:.xxxxxxxxxxxxx
11111111111111111111
11111111112222222222333333333344444444445555555555666666666677777777778888888888999999999900000000001111111111
AH0 12345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789
....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....|....:....
ABG_mVK_21_1 21B N19-8 scFv (3) F NIVLTQSPASLAVSLGQRATISCRASE..SVDSYG..NSFMHWYQQKPGQPPKLLIYL........ASNLESGVPARFSGSGSR..TDFTLTIDPVEADDAATYYCQQNNEDP.....
ABG_mVK_21_2 21C/45.21.1 PC3741 (0) F DIVLTQSPASLAVSLGQRATISCRASE..SVDSYG..NSFMHWYQQKPGQPPKLLIYR........ASNLESGIPARFSGSGSR..TDFTLTINPVEADDVATYYCQQSNEDP.....
ABG_mVK_21_3 18kb 48.2.1 (7) F DIVLTQSPASLAVSLGQRATIFCRASQ..SVDYNG..ISYMHWFQQKPGQPPKLLIYA........ASNLESGIPARFSGSGSG..TDFTLNIHPVEEEDAATYYCQQSIEDP.....
ABG_mVK_21_4 21E/21E 98QQ (2) F DIVLTQSPASLAVSLGQRATISCRASK..SVSTSG..YSYMHWYQQKPGQPPKLLIYL........ASNLESGVPARFSGSGSG..TDFTLNIHPVEEEDAATYYCQHSRELP.....
ABG_mVK_21_5 1.6kb RF-4 PAN (1) F DIVLTQSPASLAVSLGQRATISCRASQ..SVSTSS..YSYMHWYQQKPGQPPKLLIKY........ASNLESGVPARFSGSGSG..TDFTLNIHPVEEEDTATYYCQHSWEIP.....
ABG_mVK_21_6 21G S4 5A (1) F DIVLTQSPASLAVSLGQRATISCRASE..SVEYYG..TSLMQWYQQKPGQPPKLLIYA........ASNVESGVPARFSGSGSG..TDFSLNIHPVEEDDIAMYFCQQSRKVP.....
ABG_mVK_21_7 21A S3 12D (1) F DIVLTQSPASLAVSLGQRATISCRASE..SVDNYG..ISFMNWFQQKPGQPPKLLIYA........ASNQGSGVPARFSGSGSG..TDFSLNIHPMEEDDTAMYFCQQSKEVP.....
ABG_mVK_21_8 P3-X63-Ag8/HNK20 PS DIVLTQSPASLAVSLGQRATISYRASK..SVSTSG..YSYMHWNQQKPGQPPRLLIYL........VSNLESGVPARFSGSGSG..TDFTLNIHPVEEEDAATYYCQHIRE.......
ABG_mVK_21_9 CEA 66-E3 PS DIVLTQSPASLAVSLGQRATISYRASK..SVSTSG..YSYMHWNQQKPGQPPRLLIYL........VSNLESGVPARFSGSGSG..TDFTLNIHPVEEEDAATYYCQHI*GAY.....
ABG_mVK_23_1 L7 A26 (0) F DILLTQSPAILSVSPGERVSFSCRASQ..SIGT......SIHWYQQRTNGSPRLLIKY........ASESISGIPSRFSGSGSG..TDFTLSINSVESEDIADYYCQQSNSWP.....
ABG_mVK_23_2 A23A41 PS DVLLTQSPAILSVSPGERVSFSCRASQ..SIGT......SIHWYQQRTNGPPRLLIKY........ASESISGIPSRFSGSGSG..TDFTLSISSVESEDIADYYCQQTNSWP.....
ABG_mVK_23_3 MMIG21 PS DILLTQSPAILSVSPGERVSFSCRASQ..SIGT......SIHWYQQRTNGSPRLLIKN........ASESISGIPSRFSGSGSG..TDFTPSINSVESEDIAEYYCQQSYRWP.....
ABG_mVK_23_4 B1P8-7-2 PS DIVLTQSPATLSVTPGDRVSLSCRASQ..SISN......YLHWYQQKSHESPRLLIKY........ASQSISGIPSRFSGSGSG..TDFTLSINSVETEDFGMYFCQQSNSWX.....
ABG_mVK_23_5 MRL-RF33BL/MRL-n-RF33 PS DIVLTQSPATLSVTPGDSVSLSCRASQ..SISN......NLHLYQ*KSHESPRLLIKY........VFQSISEIPSKFSGSGSG..TDFTLSINSVETEDFGMYFCQQSNSWP.....
ABG_mVK_4_5_1 H3/Ox1 11G3 (0) F QIVLTQSPAIMSASPGEKVTMTCSASS..SVS.......YMHWYQQKSGTSPKRWIYD........TSKLASGVPARFSGSGSG..TSYSLTISSMEAEDAATYYCQQWSSNP.....
ABG_mVK_4_5_2 R9 58.2C.10.3 (2) F QIVLTQSPAIMSASPGEKVTMTCSASS..SIS.......YMHWYQQKPGTSPKRWIYD........TSKLASGVPARFSGSGSG..TSYSLTISSMEAEDAATYYCHQRSSYP.....
ABG_mVK_4_5_3 H13 AN01 (1) F QIVLTQSPALMSASPGEKVTMTCSASS..SVS.......YMYWYQQKPRSSPKPWIYL........TSNLASGVPARFSGSGSG..TSYSLTISSMEAEDAATYYCQQWSSNP.....
ABG_mVK_4_5_4 H9 NF QILLTQSPAIMSASPGEKVTMTCSASS..SVS.......YMHWYQQKPGSSPKPWIYD........TSNLASGFPARFSGSGSG..TSYSLIISSMEAEDAATYYCHQRSSYP.....
ABG_mVK_4_5_5 H4 163.42 (1) F QIVLTQSPAIMSASPGEKVTISCSASS..SVS.......YMYWYQQKPGSSPKPWIYR........TSNLASGVPARFSGSGSG..TSYSLTISSMEAEDAATYYCQQYHSYP.....
ABG_mVK_4_5_6 H8 PS QIVLTQSPAILSASPGEKVTMTCSASS..SVS.......YM*WFQQKPGSSPKLWIYS........ISNLASGVPARFSGSGSG..TSYSLTISSVKAEDAATYYCQQWSSSP.....
ABG_mVK_4_5_7 H6/X24 TEPC191 (0) F EIVLTQSPAITAASLGQKVTITCSASS..SVS.......YMHWYQQKSGTSPKPWIYE........ISKLASGVPARFSGSGSG..TSYSLTISSMEAEDAAIYYCQQWNYPL.....
ABG_mVK_4_5_8 R13 AN09 (3) F ENVLTQSPAIMSASLGEKVTMSCRASS..SVN.......YMYWYQQKSDASPKLWIYY........TSNLAPGVPARFSGSGSG..NSYSLTISSMEGEDAATYYCQQFTSSP.....
ABG_mVK_4_5_9 R2 NF EILLTQSPAIIAASPGEKVTITCSASS..SVS.......YMNWYQQKPGSSPKIWIYG........ISNLASGVPARFSGSGSG..TSFSFTINSMEAEDVATYYCQQRSSYP.....
ABG_mVK_4_5_10 H2 PS GIVLTQSPTTMTAFPGENVTITCSASS..SIN.......YIHWYQQKSGNTPKQ*IYK........TSDLPSGVPTLFSGSGSG..TSYSLTISSVEAEDAATYYCQQWSGYP.....
ABG_mVK_4_5_11 H1 MRL-22 (4) F QIVLTQSPAIMSASPGEKVTMTCSARS..SVSS.....SYLYWYQQKPGSSPKLWIYS........TSNLASGVPARFSGSGSG..TSYSLTISSMEAEDAATFYCQQYSQYP.....
ABG_mVK_4_5_12 R1/s107b T10-938 (15) F ENVLTQSPAIMAASLGQKVTMTCSASS..SVSS.....SYLHWYQQKSGASPKPLIHR........TSNLASGVPARFSGSGSG..TSYSLTISSVEAEDDATYYCQQWSGYP.....
ABG_mVK_4_5_13 T3B PS ....TQSPAIMAASLGEKVTMTCSASS..SVSS.....SYLHWYQQKSGTSPKPWIYG........TSNLASGVPVRFSGSGSG..TSYSLTISSMEAEDAATYYCQQWSSYP.....
ABG_mVK_4_5_14 L8 NF ENVLTQSPAIMAASLGEKVTMTCSASS..SVSS.....SYLHWYQQKSGTSPKLWIYG........TSNLASGVPARFSGSGAG..ISYSLTISSMEAENDATYYCQQWSGYP.....
ABG_mVK_4_5_15 R11 18-2-3 (12) F ENVLTQSPAIMAASPGEKVTMTCSASS..SVSS.....SNLHWYQQKSGTSTKFWIYR........TSNLASEVPAPFSGSGSG..TSYSLTISSVEAEDAATYYCQQWSGYP.....
ABG_mVK_12_13_1 k2/MMIG27 SO2 (2) F DIQMTQSPASLSASVGETVTITCRASG..NIHN......YLAWYQQKQGKSPQLLVYN........AKTLADGVPSRFSGSGSG..TQYSLKINSLQPEDFGSYYCQHFWSTP.....
ABG_mVK_12_13_2 k3 NF DIQMTQSPASLSVSVGETVTITCRASE..NIYS......NLAWLFSRNRENPPSLVYA........ATNLADGVPSRFSGSGSG..TQYSLKINSQQPEDFGSYYCQHFWSAP.....
ABG_mVK_11_1 V11 PS DVQMTQSPSSLSASLGERVSLTCQASQ..SINN......FLKWFQQTLGKTARLLIYG........ANKLEDGVPSRFSGTGYG..TDFTFTISSQEEEDVSTYFCLQHRYLP.....
ABG_mVK_9A_1 vk41/mpoc41 202.105 (10) F DIQMTQSPSSLSASLGERVSLTCRASQ..DIGS......SLNWLQQEPDGTIKRLIYA........TSSLDSGVPKRFSGSRSG..SDYSLTISSLESEDFVDYYCLQYASSP.....
ABG_mVK_9A_2 m173b BXW-16 (24) F DIQMTQSPSSLSASLGERVSLTCRASQ..DIHG......YLNLFQQKPGETIKHLIYE........TSNLDSGVPKRFSGSRSG..SDYSLIIGSLESEDFADYYCLQYASSP.....
ABG_mVK_9B_1 L6 E6 (3) F DIKMTQSPSSMYASLGERVTITCKASQ..DINS......YLSWFQQKPGKSPKTLIYR........ANRLVDGVPSRFSGSGSG..QDYSLTISSLEYEDMGIYYCLQYDEFP.....
ABG_mVK_9B_2 9B.8 PS DIQTTQSPSSMSVSLGETVSITCRASQ..GISS......YVSWLQQKPGKSPKTLISY........ATNLEDGITSWFSSSGSG..ADYSLTISSLESEDCKIYYCVQYVQLP.....
ABG_mVK_10_1 Ars/AJ1/Id(CR)/B1P8-7b Sulf-1 (0) F DIQMTQTTSSLSASLGDRVTISCRASQ..DISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEQEDIATYFCQQGNTLP.....
ABG_mVK_10_2 PERU1 hVH65-107 (1) F DIQMTQTTSSLSASLGDRVTISCRASQ..DISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEQEDIATYFCQQGSTLP.....
ABG_mVK_10_3 AKR1 NF DIQMTQTTSSLSASLGDRVTISCRASQ..DISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEQEDIATYFCQQDSKHP.....
ABG_mVK_10_4 AKR2 44.1 (4) F DIQMTQTTSSLSASLGDRVTISCRASQ..DISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEPEDIATYYCQQYSKLP.....
ABG_mVK_10_5 PERU2 NF DIQMTQTTSSLSASLGDRVTISCSASQ..GISN......YLNWYQQKPDGTVKLLIYY........TSRLHSGVPSRFSGSGSG..TDYSLTISNLEPEDIATYYCQQYSNLP.....
ABG_mVK_10_6 AJ2/B1P8-7-3 L2-10CL (0) F DIQMTQTTSSLSASLGDRVTISCSASQ..GISN......YLNWYQQKPDGTVKLLIYY........TSSLHSGVPSRFSGSGSG..TDYSLTISNLEPEDIATYYCQQYSKLP.....
ABG_mVK_10_7 V10 PS DIQMTQTTSSLSASPGDRVTISCRTSQ..DISN......FLYWFQQKSDGTVKLLIYY........TSR*HSGVPSRFSGSGSG..TDYSFTINNLE*EDVATYS*QQGILTL.....
ABG_mVK_24_25_1 167/24 C57BL 2857 (0) F DIVITQDELSNPVTSGESVSISCRSSK..SLLYKD.GKTYLNWFLQRPGQSPQLLIYL........MSTRASGVSDRFSGSGSG..TDFTLEISRVKAEDVGVYYCQQLVEYP.....
ABG_mVK_24_25_2 24A H35-C6 (11) F DIVMTQAAFSNPVTLGTSASISCRSSK..SLLHSS.GNTYLYWFLQKPGQSPQLLIYY........ISNLASGVPDRFSGSGSG..TDFTLRISRVEAEDVGVYYCMQGLEYP.....
ABG_mVK_24_25_3 24B M5 (0) F DIVMTQAAFSNPVTLGTSASISCRSSK..SLLHSN.GITYLYWYLQKPGQSPQLLIYQ........MSNLASGVPDRFSSSGSG..TDFTLRISRVEAEDVGVYYCAQNLELP.....
ABG_mVK_1_1 V-1A/K5.1/K5.1 H146-24B3 (0) F DVVMTQTPLSLPVSLGDQASISCRSSQ..SLVHSN.GNTYLHWYLQKPGQSPKLLIYK........VSNRFSGVPDRFSGSGSG..TDFTLKISRVEAEDLGVYFCSQSTHVP.....
ABG_mVK_1_2 V-IB 25.12 (1) F DVVMTQTPLSLPVSLGDQASISCRSSQ..SLVHSN.GNTYLYWYLQKPGQSPKLLIYR........VSNRFSGVPDRFSGSGSG..TDFTLKISRVEAEDLGVYFCFQGTHVP.....
ABG_mVK_1_3 V-1C NF DVVMTQTPLSLPVSLGDQASISCRSSQ..SIVHSN.GNTYLEWYLQKPGQSPKLLIYK........VSNRLSGVPDRFSGSGSG..TDFTLKISRVEAEDLGVYYCFQGSHVP.....
ABG_mVK_1_4 V-1C/V1A5/K1A5 vl6-19 (0) F DVLMTQTPLSLPVSLGDQASISCRSSQ..SIVHSN.GNTYLEWYLQKPGQSPKLLIYK........VSNRFSGVPDRFSGSGSG..TDFTLKISRVEAEDLGVYYCFQGSHVP.....
ABG_mVK_1_5 K18.1 JV3 (0) F DAVMTQTPLSLPVSLGDQASISCRSSQ..SLENSN.GNTYLNWYLQKPGQSPQLLIYR........VSNRFSGVLDRFSGSGSG..TDFTLKISRVEAEDLGVYFCLQVTHVP.....
ABG_mVK_1_6 1F PS DVLLTQTPLFLPVSLGDQASISCSSSQ..SLVHSN.GNYYLEWHLQKSGQSLQLLIYE........VSKRHSGVPDRFSGSGSG..TDFTLKISRVEPEDLGVYYCFQGTHLP.....
ABG_mVK_1_7 1E PS .......................TSSK..SLVHSN.GNSYLDWHLQKPGQSLQLLIYE........VSKRNSGVPDRFSGSGSG..TDFTLKISRVEPEDLGVYYCFQGTHLP.....
ABG_mVK_2_1 70/2 PS DVVMTQXLHSLSVTIGQPASISCKSSQ..SLLYSN.GKTYLNWLLQRPVQPPKRLIYL........VSKLYSGVPDRFSGSGSG..TDFTLKISRVXPEDLGVY*CMQDTHFP.....
ABG_mVK_2_2 70/3 LB/C1210.7 (0) F DVVMTQTPLTLSVTIGQPASISCKSSQ..SLLDSD.GKTYLNWLLQRPGQSPKRLIYL........VSKLDSGVPDRFTGSGSG..TDFTLKISRVEAEDLGVYYCWQGTHFP.....
ABG_mVK_2_3 70/1 4G11 (0) F DVVMTQTPLTLSVTIGQPASISCKSSQ..SLLYSN.GKTYLNWLLQRPGQSPKRLIYL........VSKLDSGVPDRFTGSGSG..TDFTLKISRVEAEDLGVYYCVQGTHFP.....
ABG_mVK_8_1 ABPC48 PS DIVMTQSPSSLAMSVGQKVTMSCKSSQ..SLLSSSNQKNYLAWYQQKPGQSPKLLVYF........ASTRESGXPDRFIGSGSG..TDFTLTISSVQAEDLALYYCQQHYSTP.....
ABG_mVK_8_2 GLvk50 D20 (0) F DIVMTQSPSSLSVSAGDKVTMSCKSSQ..SLLNSRNQKNYLAWYQQKPWQPPKLLIYG........ASTRESGVPDRFTGSGSG..TDFTLTISSVQAEDLAVYYCQNDYSYP.....
ABG_mVK_19_28_1 V-Serb 17F12 (7) F SIVMTQTPKFLLVSAGERVTITCKASQ..SVSN......DVAWYQQKPGQSPKLLIYY........ASNRYTGVPDRFTGSGYG..TDFTFTISTVQAEDLAVYFCQQDYSSP.....
ABG_mVK_19_28_2 V-Sera A34 (22) F SIVMTQTPKFLPVSAGDRVTMTCKASQ..SVGN......NVAWYQQKPGQSPKLLIYY........ASNRYTGVPDRFTGSGSG..TDFTFTISSVQVEDLAVYFCQQHYSSP.....
ABG_mVK_19_28_3 SK/CamRK AN12 (18) F SIVMTQTPKFLPVTAEDRVTITCKASQ..SVSN......EVAWYQQKPGQSPKLLIYY........ASNRYTGVPDRFTGSGSG..TDFTFTISSVQVEDLAVYFCQQHYSSP.....
ABG_mVK_19_28_4 PERA/Ei RF49B (18) F SIVMTQSPKSLPVSAGDRVTMTCKASQ..SVSN......DVAWYQQKPGQSPKLLIYY........ASNRYTGVPERFTGSGSG..TDFTFTISGVQAEDLAVYFCQQHYTTP.....
ABG_mVK_32_1 MUSIGKABG PS DIQMNQSPSSLSASLGDTITITCHASQ..KINV......WLSWYQQKKGNIPKLLIYR........TSNLHTGVPSRFSGSGSG..TGFTLTISSLQPEDIATYYCQQGQNYP.....
ABG_mVK_33_34_1 Vk34A 165.14 (24) F DIQMTQSSSSLSVSLGDRVTITCKASE..HINS......WLAWYQQKPGNAPRLLISG........ATSLETGVPSRFSGSASG..KDYTLSITSLQTEDVAT...............
ABG_mVK_33_34 Vk34B T10-421 (6) F DIQMTQSSSYLSVSLGGRVTITCKASE..HINS......WLAWYQQKPGNAPRLLISG........ATSLETGVPSRFSGSGSG..KDYTLSITSLQTEDVAT...............
ABG_mVK_33_34 Vk34C C8.5 (43) F DIQMTQSSSSFSVSLGDRVTITCKASE..DIYN......RLAWYQQKPGNAPRLLISG........ATSLETGVPSRFSGSGSG..KDYTLSITSLQTEDVAT...............
ABG_mVK_20_1 294A9 PS EITVTQSPASLSVATGEKVTIRRITD....IDD......EMH*YQQKPGEPPKLLISE........GNTLHPGVPSQFSSSGYG..TDFFFTIENTLSEDVADYYCLQSGNMP.....
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AHonegger, June 6, 2001